Patents by Inventor Kim A. Deal

Kim A. Deal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ac-HEHA and related compounds, methods of synthesis and methods of use
    Patent number: 6995247
    Abstract: The present invention provides an ?-particle-emitting radioisotope chelation complex comprising 225Actinium (225Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N?,N?,N?,N?,N?-hexaacetic acid (HEHA) (225Ac-HEHA). Also provided is a bifunctional HEHA, and a bifunctional 225Ac-HEHA. The bifunctional HEHA and the bifunctional 225Ac-HEHA can be conjugated to a targeting agent. In view of the above, the present invention provides a method of making HEHA and methods of making a bifunctional HEHA, including a conjugate thereof. Also provided are a method of treating disease, a method of treating cancer, a method of decontaminating a sample from 225Ac, a method of decontaminating a person who has been externally contaminated with 225Ac, and a method of detoxifying a person who has internalized 225Ac.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: February 7, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Martin W. Brechbiel, Kim Deal
  • Ac-HEHA and related compounds, methods of synthesis and methods of use
    Publication number: 20040184991
    Abstract: The present invention provides an &agr;-particle-emitting radioisotope chelation complex comprising 225Actinium (225Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N′,N′,N′,N′-hexaacetic acid (HEHA) (225Ac-HEHA). Also provided is a bifunctional HEHA, and a bifunctional 225Ac-HEHA. The bifunctional HEHA and the bifunctional 225Ac-HEHA can be conjugated to a targeting agent. In view of the above, the present invention provides a method of making HEHA and methods of making a bifunctional HEHA, including a conjugate thereof Also provided are a method of treating disease, a method of treating cancer, a method of decontaminating a sample from 225Ac, a method of decontaminating a person who has been externally contaminated with 225Ac, and a method of detoxifying a person who has internalized 225Ac.
    Type: Application
    Filed: January 28, 2004
    Publication date: September 23, 2004
    Applicant: The Government of the USA, as Represented by the Secretary, Dpt. of Health and Human Services
    Inventors: Martin W. Brechbiel, Kim Deal
  • Transition metal complexes of n, n',n?trialkyl-cis-1,3,5-triaminocyclohexane and related compositions and methods of synthesis and use
    Patent number: 6765104
    Abstract: The present invention provides transition metal complexes of N,N′,N″-trialkyl-cis,cis-1,3,5-triaminocyclohexane and related compositions and methods of synthesis and use in vitro and in vivo, such as a therapeutic agent or a delivery/imaging agent.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: July 20, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Martin Brechbiel, Roy P. Planalp, Kim Deal
  • 225Ac-HEHA and related compounds, methods of synthesis and methods of use
    Patent number: 6696551
    Abstract: The present invention provides an &agr;-particle-emitting radioisotope chelation complex comprising 225Actinium (225Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N″,N′″,N″″,N′″″-hexaacetic acid (HEHA) (225Ac-HEHA). Also provided is a bifunctional HEHA, and a bifunctional 225Ac-HEHA. The bifunctional HEHA and the bifunctional 225Ac-HEHA can be conjugated to a targeting agent. In view of the above, the present invention provides a method of making HEHA and methods of making a bifunctional HEHA, including a conjugate thereof. Also provided are a method of treating disease, a method of treating cancer, a method of decontaminating a sample from 225Ac, a method of decontaminating a person who has been externally contaminated with 225Ac, and a method of detoxifying a person who has internalized 225Ac.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: February 24, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Martin W. Brechbiel, Kim Deal
  • Copper(II) nuclease compounds, compositions, and kits
    Patent number: 5739022
    Abstract: A method is provided for nonoxidatively cleaving the phosphorus-oxygen linkage of nucleic acids and certain anticholinesterases such as insecticides using a macrocyclic copper(II) complex. A composition suited for such cleavage is also provided.
    Type: Grant
    Filed: August 18, 1994
    Date of Patent: April 14, 1998
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Judith N. Burstyn, Eric L. Hegg, Kim A. Deal