Patents by Inventor Kim De Keersmaecker

Kim De Keersmaecker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOMBINANT PROTEIN PRODUCTION SYSTEM
    Publication number: 20190360017
    Abstract: The present disclosure relates generally to an improved gene expression system in the field of recombinant gene expression. The invention relates to a system showing an improved yield and quality of protein production and methods for increasing production of a protein produced by cultured cells, particularly cultured eukaryotic cells.
    Type: Application
    Filed: December 22, 2017
    Publication date: November 28, 2019
    Inventors: Kim De Keersmaecker, Sergey O. Sulima, Tiziana Girardi, Kim R Kampen
  • Methods and compositions for the detection and treatment of cancer involving miRNAs and miRNA inhibitors and targets
    Patent number: 9624491
    Abstract: The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present invention is directed to methods and compositions for diagnosing and treating cancer, particularly T-ALL, by modulating miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing response to treatment, in assays for isolating and selecting antagonists, and as compositions for the treatment and management of cancer. Methods and compositions are provided for treatment or alleviation of cancer, particularly T-ALL, with antagonists/antagomirs of miRNAs, particularly one or more of miR-19b, miR-20a, miR26, miR92, miR148 and miR223.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: April 18, 2017
    Assignees: Memorial Sloan Kettering Cancer Center, Universiteit Gent, Columbia University
    Inventors: Hans-Guido Wendel, Andrew L. Wolfe, Konstantinos John Mavrakis, Elisa Oricchio, Adolfo A. Ferrando, Kim De Keersmaecker, Teresa Palomero, Franki Speleman, Pieter Van Vlierberghe
  • Methods and Compositions for the Detection and Treatment of Cancer involving miRNAs and miRNA Inhibitors and Targets
    Publication number: 20130064810
    Abstract: The present invention relates to microRNAs (miRNAs) which are associated with cancer, particularly including hematologic malignancies, and particularly T-cell acute lymphoblastic leukemia (T-ALL), and to the assessment and modulation thereof in the treatment and management of cancer. The present invention is directed to methods and compositions for diagnosing and treating cancer, particularly T-ALL, by modulating miRNAs, and the use of miRNAs and antagonists thereof, particularly antagomirs, for predicting and assessing response to treatment, in assays for isolating and selecting antagists, and as compositions for the treatment and management of cancer. Methods and compositions are provided for treatment or alleviation of cancer, particularly T-ALL, with antagonists/antagomirs of miRNAs, particularly one or more of miR-19b, miR-20a, miR26, miR92, miR148 and miR223.
    Type: Application
    Filed: February 28, 2011
    Publication date: March 14, 2013
    Inventors: Hans-Guido Wendel, Andrew L. Wolfe, Konstantinos John Mavrakis, Elisa Oricchio, Adolfo A. Ferrando, Kim De Keersmaecker, Teresa Palomero, Franki Speleman, Pieter Van Vlierberghe