Patents by Inventor Kim Dong Wook

Kim Dong Wook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting the histone code as a bacterial strategy for selectively modulating gene expression
    Patent number: 8092989
    Abstract: The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: January 10, 2012
    Assignees: Institut Pasteur, Inserm (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Laurence Arbibe, Philippe Sansonetti, Claude Parsot, Kim Dong Wook, Armelle Phalipon
  • Targeting the Histone Code as a Bacterial Strategy for Selectively Modulating Gene Expression
    Publication number: 20090324646
    Abstract: The ospF gene of Shigella flexneri encodes a phosphatase, which is a member of a new class of phosphatases. The OspF phosphatase inhibits the activity of several proteins either by direct protein modification or transcription downregulation. These proteins include MAP kinase, IL-8, CCL20, IL-12, AP1, CREB, RPA p32, and BCL2 related proteins. Methods for treating diseases using OspF phosphatase, methods for identifying agents that modulate OspF phosphatase's activity, methods for identifying agents that mimic OspF phosphatase's activity, and immunogenic compositions comprising OspF phosphatase are provided. A strain of Shigella flexneri containing an inactivated ospF gene is also provided.
    Type: Application
    Filed: September 15, 2006
    Publication date: December 31, 2009
    Inventors: Laurence Arbibe, Philippe Sansonetti, Claude France, Kim Dong Wook, Armelle Phalipon