Abstract: An injectable antidote for local anesthetic is disclosed. In the preferred and illustrated embodiment, it is a liquid injectable having a relatively low pH typically in the range of about 2.0 to as high as about 5.5, the preferred being about 3.5. It incorporates a biologically acceptable buffering system as for example lactic acid and a suitable salt thereof such as potassium or sodium. The system also preferably includes calcium, one form being calcium lactate. A target pH is about 3.5 for this system. In addition, a vasodilator is preferably included, and alternate additional constituents are a metabolizing agent for ester based anesthetics, and also for amide based anesthetics.