Patents by Inventor Kim Lee Sim

Kim Lee Sim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Angiostatin fragments and method of use
    Patent number: 5837682
    Abstract: Fragments of an endothelial cell proliferation inhibitor and method of use therefor are provided. The endothelial proliferation inhibitor is a protein derived from plasminogen, or more specifically is an angiostatin fragment. The angiostatin fragments generally correspond to kringle structures occurring within the endothelial cell proliferation inhibitor. The endothelial cell inhibiting activity of these fragments provides a means for inhibiting angiogenesis of tumors and for treating angiogenic-mediated disease.
    Type: Grant
    Filed: March 8, 1996
    Date of Patent: November 17, 1998
    Assignee: The Children's Medical Center Corporation
    Inventors: M. Judah Folkman, Michael S. O'Reilly, Yihai Cao, Kim Lee Sim