Abstract: The invention provides an anti-thrombogenic material and methods for manufacturing anti-thrombogenic materials. The anti-thrombogenic material of the invention is particularly suited for coating the surface substrate of medical devices which come into contact with blood and biomedical tissues. The surface of the substrate, which may be made of pure titanium or titanium alloy, is provided with a porous layer having an irregular pore structure made of alkaline titanate. With this structure, it is possible to suppress the formation of fibrin induced by activation of the blood coagulation factor such as fibrinogen on the blood contact surface by coating the surface with alkaline titanate, and also to suppress the adhesion and activation of platelets. Moreover, since titanium and titanium alloy are inert for a living body and have favorable familiarity with it and also have large strength, the materials can be used to produce anti-thrombogenic medical devices of an implantable type.

Abstract: Purpose: The object of the present invention is to provide an anti-thrombogenic material and a manufacturing method therefor permitting to surely treat a blood contact surface of complex shapes, and moreover, permitting to suppress not only generation of fibrin induced by a blood coagulation factor such as fibrinogen on the blood contact surface but also both of the adhesion and activation of platelets.