Abstract: Synthetic human cell mimic hydrogel particles and their use in cytometric or coulter device applications are described. The synthetic human cell mimic hydrogel particles described herein are selectively tunable to have at least one optical, volumetric, or capacitance property that is substantially similar to a corresponding optical, volumetric, or capacitance property of the human cell mimic hydrogel particle's natural biological cell counterpart.

Abstract: The present disclosure relates to a vaccine composition for treating multiple sclerosis. The vaccine composition of the present disclosure induces immune tolerance and suppresses autoimmune response itself, thus can be usefully applied to the treatment of multiple sclerosis.

Abstract: An electrolyzer system including a hotbox, one or more stacks disposed within the hotbox, a fuel exhaust conduit that receives fuel exhaust output by the stack, a fuel exhaust separator that separates liquid from the fuel exhaust, and a recycling conduit that fluidly connects the fuel exhaust to the fuel inlet conduit.

Abstract: To manufacture an integrated circuit (IC) device, a structure in which a first material film including silicon atoms and nitrogen atoms and a second material film devoid of nitrogen atoms is formed on a substrate. A carbonyl compound having a functional group without an ?-hydrogen is applied to the structure, and thus, an inhibitor is selectively formed only on an exposed surface of the first material film from among the first material film and the second material film.

Abstract: A method for synthesising metal oxide nanoparticles. The method comprises mixing, to provide a reaction mixture, a precursor solution comprising metal ions with an initiator solution to initiate a nanoparticle precipitation process, and then quenching the precipitation process by adding a quenching agent to the reaction mixture so as to yield a dispersion comprising metal oxide nanoparticles. The resulting metal oxide nanoparticles may have an average diameter of less than 7 nm, for example 5 nm or less.

Abstract: Hydrogel particles and their use in cytometric applications are described. The hydrogel particles described herein are selectively tunable to have at least one optical property substantially similar to at least one optical property of a target cell. In this regard, the hydrogel particles provided herein, in one aspect, are used as a calibration reagent for the detection of a target cell in a sample.

Abstract: A display apparatus includes a frame, a display panel configured to be detachable from the frame, and a position adjustment device provided between the frame and the display panel. The position adjustment device includes a first position adjusting member configured to adjust a position of the display panel in a first direction moving vertically with respect to the frame, and a second position adjusting member configured to adjust the position of the display panel in a second direction moving horizontally with respect to the frame.

Abstract: Compositions comprising multiple hydrogel particles having substantially the same diameter, but with each subgrouping of particles from the multiple hydrogel particles having different associated values for one or more passive optical properties that can be deconvoluted using cytometric instrumentation. Each hydrogel particle from the multiple hydrogel particles can be functionalized with a different biochemical or chemical target from a set of targets. A method of preparing hydrogel particles includes forming droplets and polymerizing the droplets, with optional functionalization.

Abstract: Provided herein are methods of generating optimized models of vascular grafts for subjects in certain embodiments. Methods of treating subjects in need of vascular grafts are also provided. Related systems and computer program products are additionally provided.

Abstract: Clot aspiration systems intended for removing clot from a blood vessel include an aspiration assembly which will have two or more of the following components: an aspiration catheter, an inner catheter, an intermediate catheter, and an outer catheter, the latter typically being a guiding or other sheath. A transition structure is coupled to a distal end of the aspiration assembly to cover or fill an open distal end of one or more of the components of the aspiration assembly. The transition structure may be configured to facilitate introduction of the aspiration catheter into the patient's vasculature and/or advancement of the aspiration catheter through the vasculature to a target site, such as a cerebral target site which may be occluded with clot, thrombus, or other occlusive material.

Abstract: This disclosure concerns the metabolic engineering of microorganisms to provide biosynthetic methods for the production of insect pheromones and precursors thereof in a scalable and eco-friendly fermentation reaction; for example, by converting saturated or unsaturated substrate feedstocks utilizing exogenous metabolic machinery.

Abstract: An electrolyzer system includes a steam generator configured to generate steam, a stack of solid oxide electrolyzer cells configured to generate a hydrogen stream using the steam received from the steam generator, and a water preheater configured to preheat water provided to the steam generator using heat extracted from oxygen exhaust output from the stack.

Abstract: An embodiment of a cell-oxygenation monitoring system includes a probe and a base. The probe is connectable to the base, configured to direct electromagnetic energy having wavelengths in an approximate range of 400 nm-900 nm into a body having at least one cell, and configured to receive a portion of the electromagnetic energy redirected by the body during a time. The base includes a generator configured to generate the electromagnetic energy during the time, and a computing circuit configured to determine, in response to the portion of redirected electromagnetic energy, a level of oxygenation of one or more of the at least one cell.

Abstract: A method for treating spinal nerve compression includes sequential dilation to position an instrument cannula along a patient's spine. Instruments can be delivered through the instrument cannula to remove targeted tissue for a decompression procedure. One of the instruments can be a reamer instrument configured to abrade, cut, or otherwise affect tissue along the patient's spine.

Abstract: This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

Abstract: A vehicle diagnostic includes a kiosk a display configured to depict a visual code thereon, with the visual code being readable by a handheld communication device and associated a unique electronic identifier. The kiosk additionally includes a diagnostic tool connectable to a vehicle to retrieve vehicle data therefrom. A remote server is in communication with the kiosk and is disposable in communication with the handheld communication device. The server is capable of: receiving a signal from the handheld communication device including the unique electronic identifier; receiving a signal from the kiosk including the vehicle data; analyzing the vehicle data to determine a diagnostic solution; and storing the diagnostic solution such that the diagnostic solution is retrievable in response to receipt of a subsequent signal including the unique electronic identifier.

Abstract: A method for treating spinal nerve compression includes sequential dilation to position an instrument cannula along a patient's spine. Instruments can be delivered through the instrument cannula to remove targeted tissue for a decompression procedure. One of the instruments can be a reamer instrument configured to abrade, cut, or otherwise affect tissue along the patient's spine.

Abstract: This invention relates to drug conjugates useful for localized treatment of diseases or disorders of the middle ear and/or inner ear. Methods of treating diseases or disorders of the middle ear and/or inner ear, pharmaceutical compositions comprising the conjugates, and methods of inhibiting a Tropomyosin receptor kinase are also provided.

Abstract: An aspiration catheter for removing clot from a blood vessel includes a catheter body having a scaffold extending distally from a distal end of the body. An aspiration lumen runs from the distal end to a proximal end of the body, and a central clot-receiving passage in the scaffold is contiguous with the aspiration lumen of the catheter body. A vacuum-resistant membrane covers the scaffold and establishes a clot aspiration path from a distal end of the scaffold to a proximal end of the aspiration lumen, in the catheter body so that applying a vacuum to the proximal end of the aspiration lumen can draw clot into the central clot-receiving passage. The scaffold may have a comical configuration, a cylindrical configuration, or a combination thereof, and at least a distal portion of the scaffold is radially expandable from a delivery configuration to an extraction configuration.

Abstract: A system includes a first computer system (FCS) configured to receive an authentication request of a user with respect to the first authentication system (FAS), and communicate an unsuccessful authentication attempt. In response, a bridge computer system (BCS), is configured to request a user ID and receive at least the user ID; identify an address of a second computer system (SCS) based on the user ID; and initiate the second authentication system (SAS) using the address. The SCS, if the user has been successfully authenticated with respect to the SAS, is configured to communicate successful authentication to the BCS; and in response, the BCS is configured to send the FAS a confirmation message, and the FCS is configured to treat the user as authenticated.