Abstract: The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognise an epitope of the HER2 receptor truncated form CTF-611, said epitope being defined by a sequence included in SEQ ID NO: 2, and that are capable of discriminating between CTF-611 and CTF-616 (represented by SEQ ID NO:7), preferably additionally capable of discriminating between CTF-611 and CTF-613 (represented by SEQ ID NO:6). The invention also provides a method of cancer diagnosis using the disclosed antibodies, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.

Abstract: The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognizes an epitope of a HER2 receptor truncated form, said epitope being defined by a sequence included in SEQ ID NO: 2. The invention also provides a method of cancer diagnosis, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.

Abstract: The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognise an epitope of the HER2 receptor truncated form CTF-611, said epitope being defined by a sequence included in SEQ ID NO: 2, and that are capable of discriminating between CTF-611 and CTF-616 (represented by SEQ ID NO:7), preferably additionally capable of discriminating between CTF-611 and CTF-613 (represented by SEQ ID NO:6). The invention also provides a method of cancer diagnosis using the disclosed antibodies, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.

Abstract: The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognises an epitope of a HER2 receptor truncated form, said epitope being defined by a sequence included in SEQ ID NO: 2. The invention also provides a method of cancer diagnosis, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample.

Abstract: Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such systems are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollutant degrading organisms or as biological pest control organism e.g. expressing B. thuringiensis crystalline proteins.

Abstract: Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such system are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollutant degrading organisms or as biological pest control organisms e.g. expressing B. thuringiensis crystalline proteins.

Abstract: Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such systems are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollutant degrading organisms or as biological pest control organism e.g. expressing B. thuringiensis crystalline proteins.

Abstract: Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such system are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollutant degrading organisms or as biological pest control organisms e.g. expressing B. thuringiensis crystalline proteins.

Abstract: The invention relates to a hardware implemented filtering method including establishing a representation DIS of the derivative of at least a part of a time-quantized input signal IS, and establishing at least one sample of a time- and amplitude-quantized output signal OS by performing filtering on the basis of at least a part of a filter representation IFC1, IFC2, IFC3 and the representation DIS of the derivative of at least a part of the input signal IS. The invention further relates to a hardware implemented decimation method for decimating a time-quantized input signal IS including dividing the time-quantized input signal IS into intervals, for each of the intervals establishing a sample of a time- and amplitude-quantized output signal OS according to the above mentioned filtering method. The invention further relates to a fast filtering means FFM implementing the above-mentioned methods.

Abstract: The invention relates to a self-oscillating circuit comprising comparator means (CM) comprising at least one input means (IM) and at least one output means (OM), at least one of said at least one output means (OM) is coupled to at least one of said at least one input means (IM) via at least one filtering means (FM), said at least one filtering means (FM) at least partly comprising demodulation means (DM), wherein said filtering means (FM) is of at least fifth order.

Abstract: The invention relates to an amplifier comprising amplification means (AM) comprising an input and an output, said amplification means (AM) comprising a switching output stage delivering at least one output signal (OUS) via said output, said amplification means being fed by power supply means (PSM) said amplifier further comprising compensation means (CM) providing a compensation signal (CS) derived from the power supply voltage (PSV) of the power supply means (PSM), said compensation signal (CS) comprising a substantially inverse representation of said power supply voltage (PSV) and said compensation signal (CS) being fed to said amplification means (AM). According to the invention, an effective error compensation of the output switching stage may in practice be implemented by establishment of a compensation, which on a run-time basis is based on the voltage of the power supply currently applied in the output switching stage.

Abstract: The invention relates to at least one self-oscillating loop (SOL) comprising at least one forward path (FP), at least one feedback path (FBP) wherein said at least one forward path (FP) comprises amplitude quantizing means (AQM) combined with time quantizing means (TQM) and outputting at least one time and amplitude quantized signal (OS). According to the invention, a high-speed high-resolution A/D converter may be obtained.

Abstract: The invention relates to a method of estimating an intersection between at least two continuous signal representations (SR1, SR2) in a pulse width modulator, at least one of said continuous signal representations (SR1, SR2) being non-linear, said method comprising the step of providing an intersection estimate (CPE) between said at least two continuous signal representations on the basis of at least one iteration comprising at least one iterative call of a function describing said continuous signal representations (SR1, SR2) being non-linear and whereby said estimating of intersections are performed in a pulse width modulation modulator. According to an embodiment of the invention, a simple iterative call of the established continuous signal representation, e.g. an interpolation polynomial, will provide the desired intersection. It should be noted that the established estimate might be provided without any complicated root solving and avoiding division and even square root.

Abstract: Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of proteic killer systems including the E. coli relBE locus and similar systems found in Gram-negative and Gram-positive bacteria and Archae. Such system are generally based on a cytotoxin polypeptide and an antitoxin or antidote polypeptide that in contrast to the cytotoxin is degradable by proteases. The recombinant cells are useful as vaccines, pollulant degrading organisms or as biogical pest control organisms e.g. expressing B. thuringiensis crystalline proteins.

Abstract: The invention relates to at least one self-oscillating loop (SOL) comprising at least one forward path (FP), at least one feedback path (FBP) wherein said at least one forward path (FP) comprises amplitude quantizing means (AQM) combined with time quantizing means (TQM) and outputting at least one time and amplitude quantized signal (OS). According to the invention, a high-speed high-resolution A/D converter may be obtained.

Abstract: The invention relates to a method of establishing a PWM-modulated output signal representation (OS), providing a stream of parallelly determined intersection representations (PIR) on the basis of a stream of parallel reference signal representation (PRSR) and an input signal (IS), establishing a serial PWM output signal representation (OS) by transforming said stream of parallelly determined intersection representations (PIR) into a stream of serial intersection representations (SIR) by means of a relative time shift of at least one of said parallelly determined intersections (PIR). According to an embodiment of the invention, an advantageous way of providing intersection estimates has been obtained, as each or at least a number of intersection estimates between a reference signal and an input signal may be established partially while taking only the individual partial reference functions into consideration.

Abstract: The invention relates to a parametric equalizer comprising filtering means (FM), user interface means (UIM), audio signal input means and audio signal output means, said filtering means comprising at least one filter block (FIB) said user interface means (UIM) facilitating adjustment of corner frequency (fc), Shape (Q) and gain (G), said user interface means (UIM) comprising a further adjustment parameter (SYM), said user interface means being mapped by means of coefficient adjustment algorithms (CAD) into filter coefficient settings (FCP) of the at least one filter block (FIB), which when established reflects the adjustment of the user interface means (UIM) said further adjustment parameter (SYM) providing a filter coefficient setting (FCS) comprising a combined adjustment of at least one zero frequency, pole frequency, zero Q and pole Q of at least one filter block.