Abstract: The present application relates to oligonucleotides (e.g., antisense oligonucleotides such as gapmers) designed to target DMPK RNAs and targeting complexes for delivering the oligonucleotides to cells (e.g., muscle cells) and uses thereof, particularly uses relating to treatment of disease. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits expression or activity of DMPK.

Abstract: Aspects of the disclosure relate to complexes and other aspects relate to formulations (e.g., aqueous, lyophilized forms) comprising such complexes comprising an oligonucleotide (e.g., useful for targeting DMPK) covalently linked to an antibody (e.g., anti-TfR1 antibody).

Abstract: A beverage producing device which can be connected to and transported in the passenger compartment of a vehicle and more particularly, in the cab of a truck. The beverage producing device is operable from the power source of the truck or other vehicle. This beverage producing device comprises a canister having an interior reservoir or compartment for receiving hot water with a heating core located within the reservoir. A second compartment is located in vertically spaced relationship to the first compartment. A filter may be located at one of the compartments and contains a substance capable of producing the beverage such as for example, coffee grounds, tea leaves or the like. Water passing through the substance produces a beverage which can then be introduced into a cup capable of being disposed immediately beneath an outlet on the device.