Patents by Inventor Kimberly A. Kraynyak

Kimberly A. Kraynyak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods Of Treatment Of High Grade Squamous Intraepithelial Lesion (HSIL)
    Publication number: 20230338502
    Abstract: Described are methods of treating human papillomavirus (HPV) type 16- or HPV type 18-related High-grade Squamous Intraepithelial Lesion (HSIL) of the cervix. The described methods comprise evaluating one or more biological samples for the presence of miRNAs and isomiRs thereof.
    Type: Application
    Filed: April 14, 2023
    Publication date: October 26, 2023
    Inventors: Matthew P. Morrow, Kimberly A. Kraynyak, Albert J. Sylvester, Naseem Prostak, Laurent M. Humeau
  • COMBINATION THERAPY TO TREAT BRAIN CANCER
    Publication number: 20230070723
    Abstract: Provided herein are methods of treating brain cancer in a subject, comprising evaluating one or more biological samples from a subject who has brain cancer for the presence of a miRNAs and administering interleukin-12 (IL-12); an immunogenic composition of human telomerase reverse transcriptase (hTERT), Wilms Tumor-1 (WT-1), and prostate specific membrane antigen (PSMA); and an anti-programmed cell death receptor 1 (PD-1) antibody to said subject if the subject has an increased expression level of the mIR-331-3p miRNA or isomiRs thereof and the miR-1537-3p miRNA or isomiRs thereof relative to a control population of subjects.
    Type: Application
    Filed: August 12, 2022
    Publication date: March 9, 2023
    Inventors: Amy-Lee Bredlau, Israel Lowy, Jeffrey Skolnik, Jian Yan, Bernadette Ferraro, Jewell Walters, Albert J. Sylvester, III, Kimberly A. Kraynyak, Matthew P. Morrow, Elisabeth Gillespie
  • CLINICAL AND IMMUNOLOGIC BIOMARKERS FOR REGRESSION OF HIGH GRADE CERVICAL DYSPLASIA AND CLEARANCE OF HPV16 AND HPV18 INFECTION AFTER IMMUNOTHERAPY
    Publication number: 20200282042
    Abstract: Methods for treating a subject infected with human papillomavirus and accompanying symptoms comprise assessing a sample obtained from the patient after the treatment is administered to detect the presence or absence of biomarkers associated with lesion regression and/or clearance of the virus from the subject.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 10, 2020
    Inventors: Kimberly KRAYNYAK, Matthew MORROW, Albert J. SYLVESTER
  • Herpes virus vaccine and methods of use
    Patent number: 9555100
    Abstract: Provided herein are, for example, immunogenic compositions and methods of using the same for the treatment or prevention of Herpesvirus infections.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: January 31, 2017
    Assignee: The Regents of the University of California
    Inventors: Deborah H. Spector, Christopher S. Morello, Kimberly A. Kraynyak
  • HERPES VIRUS VACCINES AND TREATMENTS
    Publication number: 20160067330
    Abstract: Provided herein are vaccine compositions and methods of their use in treating or preventing Herpes diseases.
    Type: Application
    Filed: September 10, 2015
    Publication date: March 10, 2016
    Inventors: Deborah H. Spector, Christopher S. Morello, Kimberly A. Kraynyak
  • Vaccines and immunotherapeutics comprising IL-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same
    Patent number: 9278128
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-15Ra or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: March 8, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B. Weiner, Kimberly A. Kraynyak, Michele Kutzler
  • HERPES VIRUS VACCINE AND METHODS OF USE
    Publication number: 20140193460
    Abstract: Provided herein are, inter alia, vaccines and methods of using the same for the treatment or prevention of Herpesvirus infections.
    Type: Application
    Filed: December 26, 2013
    Publication date: July 10, 2014
    Applicant: The Regents of the University of California
    Inventors: Deborah H. Spector, Christopher S. Morello, Kimberly A. Kraynyak
  • VACCINES AND IMMUNOTHERAPEUTICS COMPRISING IL-15 RECEPTOR ALPHA AND/OR NUCLEIC ACID MOLECULES ENCODING THE SAME, AND METHODS FOR USING THE SAME
    Publication number: 20140193439
    Abstract: Compositions, recombinant vaccines and live alternated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-15Ra or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Application
    Filed: January 6, 2014
    Publication date: July 10, 2014
    Inventors: DAVID B. WEINER, KIMBERLY A. KRAYNYAK, MICHELE KUTZLER
  • Vaccines and immunotherapeutics comprising IL-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same
    Patent number: 8624011
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-15Ra or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: January 7, 2014
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: David B Weiner, Kimberly A Kraynyak, Michele Kutzler
  • VACCINES AND IMMUNOTHERAPEUTICS COMPRISING IL-15 RECEPTOR ALPHA AND/OR NUCLEIC ACID MOLECULES ENCODING THE SAME, AND METHODS FOR USING THE SAME
    Publication number: 20120244180
    Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-15Ra or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.
    Type: Application
    Filed: September 14, 2010
    Publication date: September 27, 2012
    Inventors: David B. Weiner, Kimberly A. Kraynyak, Michele Kutzler