Abstract: Multipurpose skin preparations in the form of oil-in-water emulsions are disclosed. The skin preparations are prepared by combining an oil phase and an aqueous phase. The oil phase comprises a siloxane polymer, a cyclic silicone, an anti-oxidant, and an emollient. In a second version of the present invention, the oil phase includes a copolymer comprising PPG-12/SMDI. The aqueous phase comprises at least a humectant, a rheology modifier, a thickener, and water. The inventive preparations are useful in topical application to the skin, are highly water resistant, remain on the skin after multiple washings, form a protective barrier on the skin, and effectively deliver and maintain moisturizing and therapeutic agents on the skin. It is believed that the skin preparations of the present invention also effectively deliver and maintain moisturizing and select therapeutic agents, biological agents, pharmaceutical agents, and the like, which are useful for the treatment of pathologies of the skin.