Patents by Inventor Kimberly A. Marquette

Kimberly A. Marquette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200123260
    Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. The present invention also relates to a humanized antibody that specifically binds human TrkB and methods for producing and using the antibody to, inter alia, treat a hearing loss disorder.
    Type: Application
    Filed: June 26, 2019
    Publication date: April 23, 2020
    Inventors: Eric M. Bennett, Nathan Higginson-Scott, Lioudmila Tchistiakova, Kimberly A. Marquette, Janet E. Paulsen, Ruth E. Gimeno
  • Patent number: 10392438
    Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. The present invention also relates to a humanized antibody that specifically binds human TrkB and methods for producing and using the antibody to, inter alia, treat a hearing loss disorder.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: August 27, 2019
    Assignee: PFIZER INC.
    Inventors: Eric M. Bennett, Nathan Higginson-Scott, Lioudmila Tchistiakova, Kimberly A. Marquette, Janet E. Paulsen, Ruth E. Gimeno
  • Publication number: 20180179285
    Abstract: The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and. Methods for producing and purifying such engineered heterodimeric proteins and their use in diagnostics and therapeutics are also provided. The present invention also relates to a humanized antibody that specifically binds human TrkB and methods for producing and using the antibody to, inter alia, treat a hearing loss disorder.
    Type: Application
    Filed: May 13, 2015
    Publication date: June 28, 2018
    Inventors: Eric M. Bennett, Nathan Higginson-Scott, Lioudmila Tchistiakova, Kimberly A. Marquette, Janet E. Paulsen, Ruth E. Gimeno
  • Publication number: 20180162937
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Application
    Filed: January 30, 2018
    Publication date: June 14, 2018
    Applicant: WYETH LLC
    Inventors: Erwin R. BOGHAERT, Nitin K. DAMLE, Philip Ross HAMANN, Kiran KHANDKE, Arthur KUNZ, Kimberly A. MARQUETTE, Lioudmila TCHISTIAKOVA, Davinder GILL, Sreekumar R. KODANGATTIL
  • Patent number: 9902771
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: February 27, 2018
    Assignee: WYETH LLC
    Inventors: Erwin R. Boghaert, Nitin K. Damle, Philip Ross Hamann, Kiran Khandke, Arthur Kunz, Kimberly A. Marquette, Lioudmila Tchistiakova, Davinder Gill, Sreekumar R. Kodangattil
  • Publication number: 20160185859
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Application
    Filed: December 16, 2015
    Publication date: June 30, 2016
    Applicant: WYETH LLC
    Inventors: Erwin R. BOGHAERT, Nitin K. DAMLE, Philip Ross HAMANN, Kiran KHANDKE, Arthur KUNZ, Kimberly A. MARQUETTE, Lioudmila TCHISTIAKOVA, Davinder GILL, Sreekumar R. KODANGATTIL
  • Publication number: 20160008485
    Abstract: The present invention is directed to antibodies, and antigen-binding portions thereof, engineered to introduce amino acids for site-specific conjugation. The invention relates to engineered antibody constant region (Fc, C?, C?, and C?) polypeptides, and portions thereof, and antibodies comprising the polypeptides. Further, the invention relates to Fc fusion proteins comprising an engineered Fc region. The invention also relates to methods and uses of the engineered antibodies and portions for, among other things, production of antibody-drug conjugate therapeutics.
    Type: Application
    Filed: December 19, 2012
    Publication date: January 14, 2016
    Inventors: Kimberly Marquette, Eric Bennett, Lioudmila Tchistiakova, L. Nathan Tumey, Jack Bikker, Valerie Calabro, Edmund Graziani
  • Publication number: 20140308302
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Application
    Filed: May 29, 2014
    Publication date: October 16, 2014
    Inventors: Erwin R. BOGHAERT, Nitin K. DAMLE, Philip Ross HAMANN, Kiran KHANDKE, Arthur KUNZ, Kimberly A. MARQUETTE, Lioudmila TCHISTIAKOVA, Davinder GILL, Kodangattil R. SREEKUMAR
  • Patent number: 8759495
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: June 24, 2014
    Assignee: Wyeth LLC
    Inventors: Erwin R. Boghaert, Nitin K. Damle, Philip Ross Hamann, Kiran Khandke, Arthur Kunz, Kimberly A. Marquette, Lioudmila Tchistiakova, Davinder Gill, Kodangattil R. Sreekumar
  • Publication number: 20120064600
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Application
    Filed: August 11, 2011
    Publication date: March 15, 2012
    Applicant: WYETH LLC
    Inventors: Erwin R. BOGHAERT, Nitin K. Damle, Philip Ross Hamann, Kiran Khandke, Arthur Kunz, Kimberly A. Marquette, Lioudmila Tchistiakova, Davinder Gill, Kodangattil R. Sreekumar
  • Patent number: 8044178
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Grant
    Filed: March 9, 2007
    Date of Patent: October 25, 2011
    Assignee: Wyeth LLC
    Inventors: Erwin R. Boghaert, Nitin K. Damle, Philip Ross Hamann, Kiran Khandke, Arthur Kunz, Kimberly A. Marquette, Lioudmila Tchistiakova, Davinder Gill, Kodangattil Sreekumar
  • Publication number: 20100173382
    Abstract: Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same.
    Type: Application
    Filed: October 16, 2009
    Publication date: July 8, 2010
    Applicant: Wyeth
    Inventors: Erwin R. Boghaert, Nitin K. Damle, Davinder S. Gill, Kimberly A. Marquette, Lioudmila Tchistiakova, Philip Ross Hamann, Arthur Kunz
  • Publication number: 20100021483
    Abstract: Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same.
    Type: Application
    Filed: July 1, 2009
    Publication date: January 28, 2010
    Applicant: Wyeth
    Inventors: ERWIN R. BOGHAERT, Nitin K. Damle, Davinder S. Gill, Kimberly A. Marquette, Lioudmila Tchistiakova, Philip Ross Hamann, Arthur Kunz
  • Publication number: 20070298034
    Abstract: This application relates to sulfotyrosine specific antibodies that are capable of binding selectively to sulfated tyrosine (sulfotyrosine), as well as their production and use. In certain embodiments, the antibodies distinguish sulfated tyrosine containing proteins from phosphorylated tyrosine containing proteins. Methods to detect or quantitate the presence of sulfotyrosine and/or sulfotyrosine containing protein in a biological sample, by adding a sulfotyrosine specific antibody to the sample are provided. Methods to treat systemic inflammatory response syndrome and sepsis by the administration of a sulfotyrosine specific antibody are also provided.
    Type: Application
    Filed: December 8, 2006
    Publication date: December 27, 2007
    Inventors: Angela Widom, Kimberly Marquette, Gray Shaw, Louise Conroy, David Lowe
  • Publication number: 20070231333
    Abstract: Anti-5T4 antibodies, anti-5T4 antibody/drug conjugates, and methods for preparing and using the same.
    Type: Application
    Filed: March 9, 2007
    Publication date: October 4, 2007
    Applicant: Wyeth
    Inventors: Erwin BOGHAERT, Nitin Damle, Philip Hamann, Kiran Khandke, Arthur Kunz, Kimberly Marquette, Lioudmila Tchistiakova, Davinder Gill, Kodangattil Sreekumar
  • Publication number: 20070160601
    Abstract: This application relates to neutralizing antibodies that specifically bind primate PSGL-1, as well as their production and use. The antibodies reduce one or more activities of PSGL-1, such as human PSGL-1. Methods to detect or quantitate PSGL-1 in a biological sample by adding an antibody that specifically binds to PSGL-1 to the sample are provided. Further, methods to treat a primate PSGL-1 associated disorder, such as a human disorder, by administering a PSGL-1 specific antibody are also provided.
    Type: Application
    Filed: December 8, 2006
    Publication date: July 12, 2007
    Inventors: Angela Widom, Kimberly Marquette, Gray Shaw, Louise Conroy, David Lowe
  • Publication number: 20070154472
    Abstract: This application relates to sulfotyrosine specific antibodies that are capable of binding selectively to sulfated tyrosine (sulfotyrosine), as well as their production and use. In certain embodiments, the antibodies distinguish sulfated tyrosine containing proteins from phosphorylated tyrosine containing proteins. Methods to detect or quantitate the presence of sulfotyrosine and/or sulfotyrosine containing protein in a biological sample, by adding a sulfotyrosine specific antibody to the sample are provided. Methods to treat systemic inflammatory response syndrome and sepsis by the administration of a sulfotyrosine specific antibody are also provided.
    Type: Application
    Filed: February 20, 2007
    Publication date: July 5, 2007
    Inventors: Angela Widom, Kimberly Marquette, Gray Shaw, Louise Conroy, David Lowe
  • Publication number: 20060088522
    Abstract: Chimeric and humanized anti-5T4 antibodies and antibody/drug conjugates and methods for preparing and using the same.
    Type: Application
    Filed: September 9, 2005
    Publication date: April 27, 2006
    Applicant: Wyeth
    Inventors: Erwin Boghaert, Nitin Damle, Davinder Gill, Kimberly Marquette, Lioudmila Tchistiakova, Philip Hamann, Arthur Kunz
  • Publication number: 20060063228
    Abstract: This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
    Type: Application
    Filed: June 9, 2005
    Publication date: March 23, 2006
    Inventors: Marion Kasaian, Lioudmila Tchistiakova, Geertruida Veldman, Kimberly Marquette, Xiang-Yang Tan, Debra Donaldson, Laura Lin, Tania Shane, Amy Tam, Eric Feyfant, Nancy Wood, Lori Fitz, Angela Widom, Kevin Parris, Samuel Goldman, Jose Saldanha