Abstract: Disclosed herein are newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide is a human protein, which has been putatively identified as a ligand of a parathyroid hormone receptor homolog, hereinafter referred to as PTH2 Receptor. In particular, the invention relates to isolated nucleic acid molecules, such as DNA and RNA encoding a novel human tuberoinfundibular peptide of 39 residues.

Abstract: Novel GAVE1 polypeptides, proteins and nucleic acid molecules are provided. In addition to isolated, full-length GAVE1 proteins, isolated GAVE1 fusion proteins, antigenic peptides and anti-GAVE1 antibodies are provided. Moreover, GAVE1 nucleic acid molecules, recombinant expression vectors containing a nucleic acid encoding GAVE1, host cells into which the expression vectors have been introduced and nonhuman transgenic animals in which a GAVE1 gene has been introduced or disrupted are provided. Diagnostic, screening and therapeutic methods utilizing GAVE1 compositions or composition that detect GAVE1 also are provided. Methods for identifying GAVE1 agonists, antagonists, reverse agonists and the like are described.