Abstract: A test and measurement instrument includes a processor configured to execute instructions that cause the processor to: receive a bus auto-detect signal; receive signals from a bus connected to the test and measurement instrument; and apply machine learning to the signals from the bus to output a predicted a bus type; at least one memory to store the instructions and data used in the machine learning, and a display to display information for a user including the predicted bus type. A method of automatically detecting a bus type includes receiving a bus auto-detect signal when a bus is connected to a test and measurement instrument, receiving signals from the bus at a processor, and using the processor to apply machine learning to the signals from the bus to predict a bus identity.