Abstract: A sample processing/injection device for liquid chromatography comprises a septum at one end of the device, a processing chamber and injection needle disposed on a second end of the device. A fluid sample is transferred into the device by a transfer needle penetrating the septum of the device. The sample device may be positioned to a receiving component such as an injection valve of an instrument by movement of the transfer needle. The sample is injected into the receiving component through the injection needle of the sample processing/injection device through motive pressure supplied by the transfer needle. The sample processing/injection device reduces sampling steps and improves automation by performing sample processing and injection with a single device.

Abstract: A sample processing/injection device for liquid chromatography comprises a septum at one end of the device, a processing chamber and injection needle disposed on a second end of the device. A fluid sample is transferred into the device by a transfer needle penetrating the septum of the device. The sample device may be positioned to a receiving component such as an injection valve of an instrument by movement of the transfer needle. The sample is injected into the receiving component through the injection needle of the sample processing/injection device through motive pressure supplied by the transfer needle. The sample processing/injection device reduces sampling steps and improves automation by performing sample processing and injection with a single device.

Abstract: A volume-adjusting insert for sample vessels comprises an elongated body with a septum seal on one end and a seal surface on the outside of the body. A through-chamber in the body provides a receiving chamber for a hypodermic needle inserted into the septum. The seal surface of the insert defines a reduced-volume sample chamber comprising the through-chamber and the vessel chamber portion of the sample vessel below the insert, or alternatively, below the seal surface. Sample fluid injected into, or withdrawn from, the insert communicates with the through-chamber and the lower vessel chamber. The device is particularly useful in converting multi-well microplates to low sample-volume vessels for automated sampling and testing, and allows the hydraulic pressure generated by a hypodermic needle to transport the sample fluid through the sample vessel and out of a bottom-extraction element.

Abstract: A sample processing device [700] comprises an elongated body [101] with a septum seal [109] on one end and a drip tube [731] on the second end. A small-diameter through-chamber [103] in the body provides a receiving and alignment chamber for a hypodermic needle [109] inserted into the septum. A sample processing chamber [709] provides a location for processing elements such as filters and adsorption or absorption frits [135,137]. Sample fluid injected into, or withdrawn from, the device by the hypodermic needle communicates with a bottom opening [701] of the drip tube via a drip tube nozzle [705], the sample processing chamber and the small-diameter chamber. The device is particularly useful in automated testing where the device is moved to various processing locations by the hypodermic needle.

Abstract: A sample processing device [700] comprises an elongated body [101] with a septum seal [109] on one end and a drip tube [731] on the second end. A small-diameter through-chamber [103] in the body provides a receiving and alignment chamber for a hypodermic needle [109] inserted into the septum. A sample processing chamber [709] provides a location for processing elements such as filters and adsorption or absorption frits [135,137]. Sample fluid injected into, or withdrawn from, the device by the hypodermic needle communicates with a bottom opening [701] of the drip tube via a drip tube nozzle [705], the sample processing chamber and the small-diameter chamber. The device is particularly useful in automated testing where the device is moved to various processing locations by the hypodermic needle.

Abstract: A microplate assembly with closure comprises a microplate base 101 having a geometric array of wells 103. Vials 113 of borosilicate glass inserted into the wells comprise flanges on the top portion of the vials. Closure 117 comprises an array of caps 119 having a complementary geometric pattern to the wells of the microplate base. The caps each comprise a septum and are connected by a thin membrane 121. Each cap comprises a sidewall 403 having a vial engagement ring which snaps over the flange 115 of the vials. Septum openings 135 in the caps extend through the top of the caps and provide a means to fill and evacuate the vials with a penetration device passing through the septa of the caps of the closure.

Abstract: A microplate assembly with closure comprises a microplate base 101 having a geometric array of wells 103. Vials 113 of borosilicate glass inserted into the wells comprise flanges on the top portion of the vials. Closure 117 comprises an array of caps 119 having a complementary geometric pattern to the wells of the microplate base. The caps each comprises a septum and are connected by a thin membrane 121. Each cap comprises a sidewall 403 having a vial engagement ring which snaps over the flange 115 of the vials. Septum openings 135 in the caps extend through the top of the caps and provide a means to fill and evacuate the vials with a penetration device passing through the septa of the caps of the closure.