Patents by Inventor Kimberlyn F. Card
Kimberlyn F. Card has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190269807Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.Type: ApplicationFiled: April 29, 2019Publication date: September 5, 2019Inventors: Shari A. Price-Schiavi, Heather J. Belmont, Kimberlyn F. Card, Xiaoyun Zhu, Hing C. Wong
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Publication number: 20180086810Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.Type: ApplicationFiled: May 3, 2017Publication date: March 29, 2018Inventors: Jon A. Weidanz, Kimberlyn F. Card, Hing C. Wong
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Publication number: 20160199523Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.Type: ApplicationFiled: February 10, 2016Publication date: July 14, 2016Inventors: SHARI A. PRICE-SCHIAVI, Heather J. Belmont, Kimberlyn F. Card, Xiaoyun Zhu, Hing C. Wong
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Patent number: 9290560Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.Type: GrantFiled: February 18, 2014Date of Patent: March 22, 2016Assignee: ALTOR BIOSCIENCE CORPORATIONInventors: Shari A. Price-Schiavi, Heather J. Belmont, Kimberlyn F. Card, Xiaoyun Zhu, Hing C. Wong
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Publication number: 20140378656Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.Type: ApplicationFiled: February 18, 2014Publication date: December 25, 2014Applicant: ALTOR BIOSCIENCE CORPORATIONInventors: Shari A. Price-Schiavi, Heather J. Belmont, Kimberlyn F. Card, Xiaoyun Zhu, Hing C. Wong
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Patent number: 8772451Abstract: Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells.Type: GrantFiled: November 10, 2004Date of Patent: July 8, 2014Assignee: Altor BioScience CorporationInventors: Shari A. Price-Schiavi, Heather J. Belmont, Kimberlyn F. Card, Xiaoyun Zhu, Hing C. Wong
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Publication number: 20130115191Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.Type: ApplicationFiled: September 12, 2012Publication date: May 9, 2013Applicant: ALTOR BIOSCIENCE CORPORATIONInventors: Jon A. Weidanz, Kimberlyn F. Card, Hing C. Wong
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Publication number: 20120230995Abstract: The present invention relates to polyspecific binding molecules and particularly single-chain polyspecific binding molecules that include at least one single-chain T-cell receptor (sc-TCR) covalently linked through a peptide linker sequence to at least one single-chain antibody (sc-Ab). Further disclosed are methods and compositions for testing and using the molecules.Type: ApplicationFiled: December 22, 2011Publication date: September 13, 2012Applicant: Altor BioScience CorporationInventors: Jon A. Weidanz, Kimberlyn F. Card, Linda A. Sherman, Norman R. Klinman, Hing C. Wong
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Patent number: 8105830Abstract: The present invention relates to polyspecific binding molecules and particularly single-chain polyspecific binding molecules that include at least one single-chain T-cell receptor (sc-TCR) covalently linked through a peptide linker sequence to at least one single-chain antibody (sc-Ab). Further disclosed are methods and compositions for testing and using the molecules.Type: GrantFiled: November 5, 2002Date of Patent: January 31, 2012Assignee: Altor BioScience CorporationInventors: Jon A. Weidanz, Kimberlyn F. Card, Linda A. Sherman, Norman R. Klinman, Hing C. Wong
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Patent number: 7456263Abstract: The invention provides T-cell receptor (TCR) molecules comprising a V? chain and a V? chain that bind peptides derived from the p53 protein, preferably, the human p53 protein. The TCR molecules include both heterodimeric molecules and single chain molecules which specifically bind a sequence preferably spanning about amino acid positions 264-272 of the p53 protein displayed in the context of an HLA molecule, preferably, HLA-A2.1. Also disclosed are methods for making and using such TCR molecules. The invention has a wide spectrum of useful application including therapeutic uses and use in the detection of cells expressing p53 protein.Type: GrantFiled: June 5, 2002Date of Patent: November 25, 2008Inventors: Linda A. Sherman, Kimberlyn F. Card, Jon A. Weidanz, Hing C. Wong, Elizabeth L. Thomson
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Publication number: 20080269113Abstract: The invention provides T-cell receptor (TCR) molecules comprising a V? chain and a V? chain that bind peptides derived from the p53 protein, preferably, the human p53 protein. The TCR molecules include both heterodimeric molecules and single chain molecules which specifically bind a sequence preferably spanning about amino acid positions 264-272 of the p53 protein displayed in the context of an HLA molecule, preferably, HLA-A2.1. Also disclosed are methods for making and using such TCR molecules. The invention has a wide spectrum of useful application including therapeutic uses and use in the detection of cells expressing p53 protein.Type: ApplicationFiled: June 5, 2002Publication date: October 30, 2008Inventors: Linda A. Sherman, Kimberlyn F. Card, Jon A. Weidanz, Hing C. Wong, Elizabeth L. Thomson
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Publication number: 20040253632Abstract: Disclosed are methods for identifying compounds that modulate an immune complex that includes a T cell receptor (TCR) and a major histocompatibility complex (MHC) antigen. The invention has many useful applications including providing high throughput screening assays for detecting compositions that can modulate an immune response.Type: ApplicationFiled: May 16, 2001Publication date: December 16, 2004Applicant: Sunol Molecular CorporationInventors: Peter R. Rhode, Vaughan Wittman, Jon A. Weidanz, Martin Burkhardt, Kimberlyn F. Card, Rony Tal, Jorge Acevedo, Hing C. Wong
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Publication number: 20030171552Abstract: The present invention relates to polyspecific binding molecules and particularly single-chain polyspecific binding molecules that include at least one single-chain T-cell receptor (sc-TCR) covalently linked through a peptide linker sequence to at least one single-chain antibody (sc-Ab). Further disclosed are methods and compositions for testing and using the molecules.Type: ApplicationFiled: November 5, 2002Publication date: September 11, 2003Applicant: Altor BioScience CorporationInventors: Jon A. Weidanz, Kimberlyn F. Card, Linda A. Sherman, Norman R. Klinman, Hing C. Wong
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Publication number: 20030144474Abstract: Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured is methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.Type: ApplicationFiled: June 5, 2001Publication date: July 31, 2003Applicant: Sunol Molecular CorporationInventors: Jon A. Weidanz, Kimberlyn F. Card, Hing C. Wong
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Patent number: 6534633Abstract: The present invention relates to polyspecific binding molecules and particularly single-chain polyspecific binding molecules that include at least one single-chain T-cell receptor (sc-TCR) covalently linked through a peptide linker sequence to at least one single-chain antibody (sc-Ab). Further disclosed are methods and compositions for testing and using the molecules.Type: GrantFiled: October 21, 1999Date of Patent: March 18, 2003Assignee: Altor Bioscience CorporationInventors: Jon A. Weidanz, Kimberlyn F. Card, Linda A. Sherman, Norman R. Klinman, Hing C. Wong