Patents by Inventor Kimihiro Mabuchi
Kimihiro Mabuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11014053Abstract: A hollow fiber membrane including a dense layer at least on an inner surface side of the hollow fiber membrane, in which when the inner surface of the hollow fiber membrane is observed under an atomic force microscope, a plurality of groove-like recesses oriented in a lengthwise direction of the hollow fiber membrane are observed, an aspect ratio defined as a ratio of a length to a width of each of the recesses is greater than or equal to 3 and less than or equal to 30, a yield strength of the hollow fiber membrane in a dry state is greater than or equal to 30 g/filament, and a breaking elongation is less than or equal to 20%/filament.Type: GrantFiled: October 31, 2017Date of Patent: May 25, 2021Assignee: TOYOBO CO., LTD.Inventors: Kimihiro Mabuchi, Haruhiko Kohyama, Yoshinori Takii
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Patent number: 11007490Abstract: The present invention provides a hollow fiber membrane including a cellulose acetate-based polymer, in which when an inner surface of the hollow fiber membrane is observed under an atomic force microscope, a plurality of groove-like recesses oriented in a lengthwise direction of the hollow fiber membrane are observed, an average length of the recesses is greater than or equal to 200 nm and less than or equal to 500 nm, an average width of the recesses is greater than or equal to 15 nm and less than or equal to 50 nm, and an aspect ratio defined as a ratio of the average length to the average width of each of the recesses is greater than or equal to 6 and less than or equal to 22.Type: GrantFiled: October 31, 2017Date of Patent: May 18, 2021Assignee: TOYOBO CO., LTD.Inventors: Kimihiro Mabuchi, Haruhiko Kohyama, Yoshinori Takii
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Publication number: 20200070099Abstract: A hollow fiber membrane including a dense layer at least on an inner surface side of the hollow fiber membrane, in which when the inner surface of the hollow fiber membrane is observed under an atomic force microscope, a plurality of groove-like recesses oriented in a lengthwise direction of the hollow fiber membrane are observed, an aspect ratio defined as a ratio of a length to a width of each of the recesses is greater than or equal to 3 and less than or equal to 30, a yield strength of the hollow fiber membrane in a dry state is greater than or equal to 30 g/filament, and a breaking elongation is less than or equal to 20%/filament.Type: ApplicationFiled: October 31, 2017Publication date: March 5, 2020Applicant: TOYOBO CO., LTD.Inventors: Kimihiro Mabuchi, Haruhiko Kohyama, Yoshinori Takii
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Publication number: 20190270051Abstract: The present invention provides a hollow fiber membrane including a cellulose acetate-based polymer, in which when an inner surface of the hollow fiber membrane is observed under an atomic force microscope, a plurality of groove-like recesses oriented in a lengthwise direction of the hollow fiber membrane are observed, an average length of the recesses is greater than or equal to 200 nm and less than or equal to 500 nm, an average width of the recesses is greater than or equal to 15 nm and less than or equal to 50 nm, and an aspect ratio defined as a ratio of the average length to the average width of each of the recesses is greater than or equal to 6 and less than or equal to 22.Type: ApplicationFiled: October 31, 2017Publication date: September 5, 2019Applicant: TOYOBO CO., LTD.Inventors: Kimihiro Mabuchi, Haruhiko Kohyama, Yoshinori Takii
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Patent number: 10137234Abstract: The invention provides a method for sterilizing a blood purifier, as well as a blood purifier package. The method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and is highly reliable in safety when employed for hemocatharsis therapy. The method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: GrantFiled: May 27, 2015Date of Patent: November 27, 2018Assignee: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9987409Abstract: The invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The blood purifier comprises selectively permeable separation membranes as a main component and is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.Type: GrantFiled: May 27, 2015Date of Patent: June 5, 2018Assignee: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9987408Abstract: Objects of the invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: GrantFiled: May 27, 2015Date of Patent: June 5, 2018Assignee: NIPRO CORPORATIONInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Publication number: 20150320921Abstract: The invention provides a method for sterilizing a blood purifier, as well as a blood purifier package. The method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and is highly reliable in safety when employed for hemocatharsis therapy. The method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: ApplicationFiled: May 27, 2015Publication date: November 12, 2015Applicant: NIPRO CORPORATIONInventors: Takashi SUNOHARA, Yuuki HATAKEYAMA, Noriko MONDEN, Toshiaki MASUDA, Noriaki KATO, Kimihiro MABUCHI
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Publication number: 20150258264Abstract: The invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The blood purifier comprises selectively permeable separation membranes as a main component and is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.Type: ApplicationFiled: May 27, 2015Publication date: September 17, 2015Applicant: NIPRO CORPORATIONInventors: Kimihiro MABUCHI, Noriko MONDEN, Noriaki KATO, Yuuki HATAKEYAMA, Takashi SUNOHARA, Toshiaki MASUDA
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Publication number: 20150258265Abstract: Objects of the invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: ApplicationFiled: May 27, 2015Publication date: September 17, 2015Applicant: NIPRO CORPORATIONInventors: Kimihiro MABUCHI, Noriko MONDEN, Noriaki KATO, Yuuki HATAKEYAMA, Takashi SUNOHARA, Toshiaki MASUDA
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Patent number: 9067178Abstract: Objects of the present invention are to provide a blood purifier package which shows a less increase in the amounts of extracts from the materials of its blood purifier, particularly of its selective permeable separation membranes, attributed to the deterioration of the same materials with time after exposure to a radioactive ray or an electron ray, and which is therefore highly reliable in safety in use for hemocatharsis, and to provide a process for manufacturing the same. The present invention relates to a blood purifier package obtained by packing a blood purifier which comprises selectively permeable separation membranes as a main component, and this blood purifier package is characterized in that the blood purifier is packed and sealed together with an oxygen scavenger in a packaging material capable of shutting out an external air and a water vapor, under a condition of a relative humidity of above 40% RH at 25° C.Type: GrantFiled: December 2, 2005Date of Patent: June 30, 2015Assignee: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9056280Abstract: The present invention provides a method for sterilizing a blood purifier, which method is effective to decrease the amounts of extracts from the blood purifier attributed to the deterioration of the selectively permeable separation membranes with time during and after exposure to a radioactive ray or an electron ray, and which method is highly reliable in safety when employed for hemocatharsis therapy. The present invention also provides a blood purifier package. The present invention relates to a method for sterilizing a blood purifier which comprises substantially dried selectively permeable separation membranes as a main component, by way of the exposure of the same blood purifier to a radioactive ray and/or an electron ray, and this method is characterized in that the blood purifier is sealed in a packaging bag, together with an oxygen scavenger and a humectant or together with an oxygen scavenger capable of releasing a moisture, and is then sterilized in such a sealed state by the above exposure.Type: GrantFiled: October 13, 2005Date of Patent: June 16, 2015Assignee: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 9050410Abstract: The present invention provides a blood purifier which shows a decreased amount of hydrogen peroxide extracted from its selectively permeable separation membranes, and thus is highly reliable in its safety in use for hemecatharysis. The present invention relates to a blood purifier which comprises selectively permeable separation membranes as a main component and which is characterized in that the amount of hydrogen peroxide which is extracted from the selectively permeable separation membrane removed from the blood purifier after 3 months or longer has passed since the sterilization of the blood purifier by exposure to a radioactive ray and/or an electron ray is not larger than 10 ppm.Type: GrantFiled: October 13, 2005Date of Patent: June 9, 2015Assignee: Nipro CorporationInventors: Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 8840788Abstract: The present invention provides a hollow fiber membrane where the membrane strength and pressure resistance to pressurization from the dialysate side is ensured, the retaining rate of water permeability after the repeated pressure load from outside is high, the resistance to the pressure from outside is excellent and the assembling property into module (low leakage rate at the adhered part) is satisfactory at the same time. The present invention also provides a method for manufacturing the same, and a blood purification module.Type: GrantFiled: February 2, 2010Date of Patent: September 23, 2014Assignee: Toyo Boseki Kabushiki KaishaInventors: Makoto Ohno, Isamu Yamamoto, Takahito Sagara, Kimihiro Mabuchi, Tohru Uenishi, Shinya Koyama
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Publication number: 20110290709Abstract: The present invention provides a hollow fiber membrane where the membrane strength and pressure resistance to pressurization from the dialysate side is ensured, the retaining rate of water permeability after the repeated pressure load from outside is high, the resistance to the pressure from outside is excellent and the assembling property into module (low leakage rate at the adhered part) is satisfactory at the same time. The present invention also provides a method for manufacturing the same, and a blood purification module. An annealing spinning method was found where a spinning dope is discharged from a nozzle into a coagulation bath, an appropriate elongation is applied so as to enhance the membrane strength, an elongation is continued during a water-washing step so as not to relax the elongation, and no elongation is applied during drying whereby the strain is relaxed.Type: ApplicationFiled: February 2, 2010Publication date: December 1, 2011Applicant: TOYO BOSEKI KABUSHIKI KAISHAInventors: Makoto Ohno, Isamu Yamamoto, Takahito Sagara, Kimihiro Mabuchi, Tohru Uenishi, Shinya Koyama
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Patent number: 7922007Abstract: The present invention relates to a permselective separation membrane that can be used in blood purifying treatment. More particularly, the present invention relates to a polysulfone-based permselective separation membrane which has well-balanced separation properties, highly stable safety and performance, and also can be smoothly assembled into a module, and a method for producing the same.Type: GrantFiled: March 18, 2005Date of Patent: April 12, 2011Assignee: Toyo Boseki Kabushiki KaishaInventors: Kimihiro Mabuchi, Hideyuki Yokota, Katsuaki Kuze, Noriyuki Tamamura, Makoto Ono, Noriko Monden, Noriaki Kato, Hiroshi Shibano, Katsuhiko Nose
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Patent number: 7837042Abstract: The invention relates to a hollow fiber membrane module comprising polysulfone type selectively permeable hollow fiber membranes which contain a polysulfone-based resin and a hydrophilic polymer as main components, wherein (A) the content of the hydrophilic polymer in the uppermost layer of the inner surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the inner surface of the membrane, and (B) the content of the hydrophilic polymer in the uppermost layer of the outer surface of the hollow fiber membrane is at least 1.1 times larger than the content of the hydrophilic polymer in the uppermost layer of the inner surface of the membrane. The hollow fiber membrane module is exposed to a radioactive ray, on condition that the oxygen concentration of an ambient atmosphere around the hollow fiber membrane is from 0.001 to 0.1%, and that the moisture content of the hollow fiber membrane to the weight thereof is from 0.2 to 7 mass %.Type: GrantFiled: August 9, 2005Date of Patent: November 23, 2010Assignee: Nipro CorporationInventors: Hideyuki Yokota, Kimihiro Mabuchi, Noriko Monden, Noriaki Kato, Yuuki Hatakeyama, Takashi Sunohara, Toshiaki Masuda
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Patent number: 7638052Abstract: The present invention provides a polysulfone type hollow fiber membrane which is reliable in safety and stability of performance and is easily incorporated into a module, and thus can be suitably used in a highly water permeable blood purifier for use in a therapy of chronic renal failure. The present invention relates to a polysulfone type selectively permeable hollow fiber membrane comprising a polysulfone type resin and a hydrophilic polymer as main components, and characterized in that (A) the content of the hydrophilic polymer in the uppermost layer of a surface of the polysulfone type hollow fiber membrane on the blood-contacting side is at least 1.1 times larger than the content of the hydrophilic polymer in the proximate layer of the surface on the blood-contacting side, and (B) the content of the hydrophilic polymer in the uppermost layer of the other surface of the polysulfone type hollow fiber membrane, i.e., the reverse side of the surface on the blood-contacting side, is at least 1.Type: GrantFiled: June 2, 2004Date of Patent: December 29, 2009Assignee: Toyo Boseki Kabushiki KaishaInventors: Kimihiro Mabuchi, Noriyuki Tamamura, Hidehiko Sakurai, Noriaki Kato, Hiroshi Shibano, Katsuhiko Nose
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Publication number: 20090272686Abstract: [Purpose] To provide a blood purifier which has high levels of blood compatibility, performance-retaining property when in contact with blood, and safety, and which shows an excellent water permeability-exhibiting rate after a priming treatment and has high reliability in long-term storage.Type: ApplicationFiled: April 3, 2006Publication date: November 5, 2009Applicant: TOYO BOSEKI KABUSHIKI KAISHAInventors: Kimihiro Mabuchi, Hideyuki Yokota, Katsuaki Kuze, Noriko Monden, Noriaki Kato, Makoto Ohno, Mitsuru Suzuki
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Patent number: 7442302Abstract: The present invention provides a highly water permeable hollow fiber membrane type blood purifier for medical use, which is excellent in safety and module-assembling ease and which has a high water permeability suitable for use in therapy of chronic renal failure. The present invention relates to a highly water-permeable hollow fiber type blood purifier comprising hydrophobic polymer hollow fiber membranes each of which contains a hydrophilic polymer, characterized in that the amount of the hydrophilic polymer eluted from the hollow fiber membrane is 10 ppm or less; in that the ratio of the hydrophilic polymer in the outer surface of the hollow fiber membrane is 25 to 50 mass %; in that the burst pressure of the hollow fiber membrane is 0.5 MPa or higher; and in that the coefficient of water permeability of the blood purifier is 150 ml/m2/hr./mmHg or higher.Type: GrantFiled: August 26, 2004Date of Patent: October 28, 2008Assignee: Toyo Boseki Kabushiki KaishaInventors: Kimihiro Mabuchi, Noriyuki Tamamura, Hidehiko Sakurai, Noriko Monden, Shinya Koyama, Hiroshi Shibano, Katsuaki Kuze, Katsuhiko Nose