Patents by Inventor Kiminobu Sugaya

Kiminobu Sugaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190183898
    Abstract: Disclosed herein are methods and materials for improving brain function and/or promoting neurogenesis m a patient suffering from impaired brain function. Specifically exemplified herein ls the co-administration of phenserine and NBI-18. A method of treating a neurodegenerative disease in a patient in need thereof, said method comprising co-administering to the patient phenserine, or pharmaceutically acceptable salt thereof, and NBI-18, or pharmaceutically acceptable salt thereof, in respective amounts and frequency such that they work together to improve brain function or induce neurogenesis in the patient.
    Type: Application
    Filed: June 6, 2017
    Publication date: June 20, 2019
    Inventor: Kiminobu SUGAYA
  • Publication number: 20190167674
    Abstract: Disclosed herein are methods for increasing the overall vigor of a subject, and/or vigor of target tissues of a subject. Exemplified herein is the utilization of pyrimidine derivatives which act to stimulate stem cell proliferation. In addition to increasing vigor, such stem cell proliferation agents (SCPA) may be used to enhance and/or improve the outcome of other therapies, and may be used in psychiatric applications. Increasing vigor in subjects is not necessarily targeted to the treatment of a disease, thus, the methods can include administration to clinically healthy animals.
    Type: Application
    Filed: February 6, 2019
    Publication date: June 6, 2019
    Inventors: Kiminobu SUGAYA, Angel ALVAREZ
  • Publication number: 20180092913
    Abstract: Disclosed herein are methods for increasing the overall vigor of a subject, and/or vigor of target tissues of a subject. Exemplified herein is the utilization of pyrimidine derivatives which act to stimulate stem cell proliferation. In addition to increasing vigor, such stem cell proliferation agents (SCPA) may be used to enhance and/or improve the outcome of other therapies, and may be used in psychiatric applications. Increasing vigor in subjects is not necessarily targeted to the treatment of a disease, thus, the methods can include administration to clinically healthy animals.
    Type: Application
    Filed: October 6, 2017
    Publication date: April 5, 2018
    Inventors: Kiminobu SUGAYA, Angel ALVAREZ
  • Patent number: 9791938
    Abstract: Systems and methods for camera-based fingertip tracking are disclosed. One such method includes identifying at least one location of a fingertip in at least one of the video frames, and mapping the location to a user input based on the location of the fingertip relative to a virtual user input device.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: October 17, 2017
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Andrew Sugaya
  • Publication number: 20160357267
    Abstract: Systems and methods for camera-based fingertip tracking are disclosed. One such method includes identifying at least one location of a fingertip in at least one of the video frames, and mapping the location to a user input based on the location of the fingertip relative to a virtual user input device.
    Type: Application
    Filed: August 17, 2016
    Publication date: December 8, 2016
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Andrew Sugaya
  • Patent number: 9506031
    Abstract: Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: November 29, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Angel Alvarez
  • Publication number: 20160331698
    Abstract: Disclosed herein are small-gap fullerene compositions and methods of using for therapeutic or cosmetic purposes. Specifically exemplified is the use of derivatized SGFs so as to be water-soluble. The derivatized SGFs include polyhydroxylated and polycarboxylated SGFs.
    Type: Application
    Filed: January 13, 2015
    Publication date: November 17, 2016
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu SUGAYA, Alexander TORRES
  • Patent number: 9358234
    Abstract: This invention provides methods for preparing novel mammalian multipotent stem cells (MSCs), compositions thereof, and methods of preparing and administering the cells.
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: June 7, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Kiminobu Sugaya, Tingyu Qu, Ankur V. Vaghani, Christopher Brannen, Hojoong M. Kim, Jose S. Pulido, Xiajing Dong
  • Patent number: 9243226
    Abstract: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells or mesenchymal stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.
    Type: Grant
    Filed: February 25, 2008
    Date of Patent: January 26, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Angel Alvarez
  • Publication number: 20150316988
    Abstract: Systems and methods for camera-based fingertip tracking are disclosed. One such method includes identifying at least one location of a fingertip in at least one of the video frames, and mapping the location to a user input based on the location of the fingertip relative to a virtual user input device.
    Type: Application
    Filed: April 2, 2015
    Publication date: November 5, 2015
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Andrew Sugaya
  • Publication number: 20150258148
    Abstract: The present invention is directed to methods and systems directed to altering the differentiation of a cell, more particularly to biasing a potent cell, such as a mesenchymal stem cell, by contacting such cell with a protein having properties of bone morphogenic protein-4. The contacting may be achieved via genetic modification, and the resulting cell may be or have characteristics of a pre-adipocyte. Pre-adipocyte cells so-obtained, and their progeny, may be used for various purposes, including in cosmetic and other surgical therapies and treatments.
    Type: Application
    Filed: June 6, 2013
    Publication date: September 17, 2015
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventor: Kiminobu Sugaya
  • Patent number: 9127291
    Abstract: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: September 8, 2015
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Angel Alvarez, Amelia Marutle
  • Patent number: 9095573
    Abstract: Disclosed herein are methods and materials for promoting neurogenesis of endogenous and transplanted stem cells. Specifically exemplified herein are methods that comprise transplanting neural stem cells in conjunction with a regimen of (+)phenserine treatment.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: August 4, 2015
    Inventors: Kiminobu Sugaya, Amelia Marutle, Young Don Kwak
  • Patent number: 9084789
    Abstract: Disclosed herein are methods and materials for improving vision. Particularly exemplified herein are pyrimidine compounds that serve to proliferate retinal stem cells.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: July 21, 2015
    Assignee: Board of Trustees of the University of Illinois
    Inventors: Kiminobu Sugaya, Tingyu Qu
  • Publication number: 20150147813
    Abstract: Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.
    Type: Application
    Filed: December 8, 2014
    Publication date: May 28, 2015
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Angel Alvarez
  • Patent number: 9001036
    Abstract: Systems and methods for camera-based fingertip tracking are disclosed. One such method includes identifying at least one location of a fingertip in at least one of the video frames, and mapping the location to a user input based on the location of the fingertip relative to a virtual user input device.
    Type: Grant
    Filed: June 12, 2012
    Date of Patent: April 7, 2015
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Andrew Sugaya
  • Publication number: 20150056704
    Abstract: Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell.
    Type: Application
    Filed: August 19, 2013
    Publication date: February 26, 2015
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Angel Alvarez, Amelia Marutle
  • Publication number: 20150051558
    Abstract: Disclosed herein in exemplary embodiments are methods and compositions for repairing or treating a defected cornea in a patient in need. The methods and compositions including, for example, administering a dose of a composition to the patient, wherein the composition comprises may be administered to an intraocular area of the patient via a container having a spout for ophthalmic delivery. The methods and compositions promote progenitor cell migration and increase cellular proliferation in the cornea of the patient.
    Type: Application
    Filed: March 13, 2013
    Publication date: February 19, 2015
    Inventor: Kiminobu Sugaya
  • Patent number: 8906683
    Abstract: Disclosed herein are methods and materials for producing a more developmentally potent cell from a less developmentally potent cell. Specifically exemplified herein are methods that comprise introducing an expressible dedifferentiating polynucleotide sequence into a less developmentally potent cell, wherein the transfected less developmentally potent cell becomes a more developmentally potent cell capable of differentiating to a less developmentally potent cell of its lineage of origin or a different lineage.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: December 9, 2014
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Angel Alvarez
  • Patent number: 8791128
    Abstract: Disclosed herein are novel methods and compositions for treating and/or preventing hair loss in patients. Specifically exemplified herein are compositions containing a modified pyrimidine that are topically applied to a scalp of an patient. Typically, the patient has androgenic alopecia, alopecia greata, postpartum alopecia or telogen effluvium.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: July 29, 2014
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Kiminobu Sugaya, Stephanie Merchant