Patents by Inventor Kiminori Tomimatsu
Kiminori Tomimatsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7038042Abstract: A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the formula: {wherein Z represents an electron-attracting group; W represents optionally substituted ethylene or optionally substituted vinylene; R3 represents hydrogen or an optionally substituted hydrocarbon group; and X represents a divalent group [provided that when W represents optionally substituted vinylene, then —X—CH2-Z is not —X1—X2—CH2, -Z (wherein X1 represents sulfur or optionally substituted nitrogen and X2 represents optionally substituted ethylene)]} or a salt thereof, is characterized by subjecting a compound represented by the formula (II) or a salt thereof: (wherein the symbols have the same meanings as the above) to a ring closure reaction in a solvent containing a carbonic diester.Type: GrantFiled: December 10, 2004Date of Patent: May 2, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Tatsuya Ito, Kiminori Tomimatsu
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Patent number: 6982344Abstract: A method including resolution of a diastereomeric mixture represented by the formula wherein R1 and R2 are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, only one of R1 and R2 contains one asymmetric carbon, and Ra is an optically active and optionally substituted hydrocarbon group or an optically active and optionally substituted heterocyclic group, or a salt thereof, to produce the diastereomer having a steric configuration of the asymmetric carbon for R1 or R2 of an R configuration or an S configuration, or a salt thereof.Type: GrantFiled: October 17, 2001Date of Patent: January 3, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Tomomi Ikemoto, Atsuko Nishiguchi, Kiminori Tomimatsu
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Publication number: 20050096475Abstract: A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the formula: {wherein Z represents an electron-attracting group; W represents optionally substituted ethylene or optionally substituted vinylene; R3 represents hydrogen or an optionally substituted hydrocarbon group; and X represents a divalent group [provided that when W represents optionally substituted vinylene, then —X—CH2-Z is not —X1—X2—CH, -Z (wherein X1 represents sulfur or optionally substituted nitrogen and X2 represents optionally substituted ethylene)]} or a salt thereof, is characterized by subjecting a compound represented by the formula (II) or a salt thereof: (wherein the symbols have the same meanings as the above) to a ring closure reaction in a solvent containing a carbonic diester.Type: ApplicationFiled: December 10, 2004Publication date: May 5, 2005Inventors: Tomomi Ikemoto, Tatsuya Ito, Kiminori Tomimatsu
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Patent number: 6881842Abstract: A process for easily and industrially advantageously producing both a tricyclic fused heterocyclic derivative having acetylcholinesterase inhibitory activity and an intermediate for the derivative. The process for producing the target compounds comprises the following reaction.Type: GrantFiled: September 20, 2001Date of Patent: April 19, 2005Assignee: Takeda Chemical Industries, Ltd.Inventors: Tadao Kawarasaki, Hideo Hashimoto, Kiminori Tomimatsu
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Patent number: 6864367Abstract: A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor. The process, which is for producing a compound represented by the formula: {wherein Z represents an electron-attracting group; W represents optionally substituted ethylene or optionally substituted vinylene; R3 represents hydrogen or an optionally substituted hydrocarbon group; and X represents a divalent group [provided that when W represents optionally substituted vinylene, then —X—CH2—Z is not —X1—X2—CH2—Z (wherein X1 represents sulfur or optionally substituted nitrogen and X2 represents optionally substituted ethylene)]} or a salt thereof, is characterized by subjecting a compound represented by the formula (II) or a salt thereof: (wherein the symbols have the same meanings as the above) to a ring closure reaction in a solvent containing a carbonic diester.Type: GrantFiled: February 20, 2001Date of Patent: March 8, 2005Assignee: Takeda Chemical Industries, Ltd.Inventors: Tomomi Ikemoto, Tatsuya Ito, Kiminori Tomimatsu
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Publication number: 20040106803Abstract: A method for producing a compound of the formula: 1Type: ApplicationFiled: November 4, 2003Publication date: June 3, 2004Inventors: Tomomi Ikemoto, Tatsuya Ito, Kiminori Tomimatsu, Yasuhiro Sawai, Hirohiko Nishiyama, Yasushi Isogami
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Patent number: 6743924Abstract: A method for producing a compound of the formula: (1) in a secondary or tertiary alcohol in the presence of a base, or (2) in the absence of a base is provided.Type: GrantFiled: April 19, 2002Date of Patent: June 1, 2004Assignee: Takeda Chemical Industries, Ltd.Inventors: Tomomi Ikemoto, Tatsuya Ito, Kiminori Tomimatsu, Yasuhiro Sawai, Hirohiko Nishiyama, Yasushi Isogami
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Publication number: 20040049041Abstract: A method including resolution of a diastereomeric mixture represented by the formula 1Type: ApplicationFiled: April 11, 2003Publication date: March 11, 2004Inventors: Tomomi Ikemoto, Atsuko Nishiguchi, Kiminori Tomimatsu
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Publication number: 20030191150Abstract: A process for easily and industrially advantageously producing both a tricyclic fused heterocyclic derivative having acetylcholinesterase inhibitory activity and an intermediate for the derivative. The process for producing the target compounds comprises the following reaction.Type: ApplicationFiled: March 20, 2003Publication date: October 9, 2003Inventors: Tadao Kawarasaki, Hideo Hashimoto, Kiminori Tomimatsu
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Patent number: 6566535Abstract: A process for preparing a compound represented by the following formula: wherein each symbol is as defined below, or a salt thereof, characterized by subjecting a compound represented by the following formula: wherein R1 is an electron-attracting group; R2, R3, R4, R5, R6 and R7 are each a hydrogen atom, a halogen atom, an optionally substituted amino group, an optionally substituted hydroxyl group, an optionally substituted thiol group, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group, provided that R6 and R7 may be united to form a ring; and R8 is a hydrogen atom or an optionally substituted hydrocarbon group, or a salt thereof, to a ring-closing reaction.Type: GrantFiled: November 7, 2001Date of Patent: May 20, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Tatsuya Ito, Tomomi Ikemoto, Kiminori Tomimatsu
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Publication number: 20030069419Abstract: A method for producing a compound of the formula: 1Type: ApplicationFiled: April 19, 2002Publication date: April 10, 2003Inventors: Tomomi Ikemoto, Tatsuya Ito, Kiminori Tomimatsu, Yasuhiro Sawai, Hirohiko Nishiyama, Yasushi Isogami
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Publication number: 20030040632Abstract: A process suitable for safely mass-producing, through a short step, cyclic compounds useful in medicines, agricultural chemicals, foods, cosmetics, and chemical products or as intermediates therefor.Type: ApplicationFiled: August 19, 2002Publication date: February 27, 2003Inventors: Tomomi Ikemoto, Tatsuya Ito, Kiminori Tomimatsu
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Publication number: 20010051631Abstract: Tricyclic compound of the formula: 1Type: ApplicationFiled: June 4, 2001Publication date: December 13, 2001Inventors: Muneo Takatani, Yumiko Shibouta, Kiminori Tomimatsu, Tetsuji Kawamoto
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Patent number: 6251905Abstract: Tricyclic compound of the formula: wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.Type: GrantFiled: January 21, 1999Date of Patent: June 26, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Yumiko Shibouta, Kiminori Tomimatsu, Tetsuji Kawamoto
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Patent number: 5958942Abstract: Tricyclic compound of the formula: ##STR1## wherein ring A is a nitrogen-containing heterocyclic ring, having two nitrogen atoms as the hetero-atoms, which is optionally substituted with oxo or thioxo; ring Q may optionally be substituted; Y is an optionally substituted hydrocarbon group, an optionally substituted hydroxyl group or an optionally substituted mecapto group, excluding for methyl group as Y; R.sup.1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or an acyl group, or a salt thereof, having excellent PDGF-inhibiting activities, antihypertensive activities, activities of ameliorating renal diseases and activities of lowering lipid level.Type: GrantFiled: January 14, 1997Date of Patent: September 28, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Yumiko Shibouta, Kiminori Tomimatsu, Tetsuji Kawamoto
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Patent number: 5767121Abstract: There is disclosed a pharmaceutical composition for providing antiinflammatory, antipyretic, analgesic, antiallergic, immunosuppressing or immunomodulating activity which comprises a pyridine derivative of the formula (I): ##STR1## wherein R is an optionally substituted pyridine ring, X is a oxygen atom or --S(O).sub.n --, wherein n is 0, 1 or 2, A is a bivalent C.sub.1-15 hydrocarbon residue whose branched moiety may have a substituent, Y is an oxygen or sulfur atom, R.sub.3 is a hydrogen atom or an optionally substituted hydrocarbon residue, R.sub.4 is an optionally substituted hydrocarbon residue or an optionally substituted monocyclic or bicyclic heterocyclic group, R.sub.3 and R.sub.4 may be joined together with the carbamoyl group or the thiocarbamoyl group to which they are attached to form an optionally substituted heterocyclic group, or R.sub.3 or R.sub.Type: GrantFiled: September 20, 1996Date of Patent: June 16, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Taketoshi Saijo, Kiminori Tomimatsu
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Patent number: 5587383Abstract: A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.Type: GrantFiled: February 10, 1995Date of Patent: December 24, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Yoshio Kozai, Kiminori Tomimatsu, Yumiko Shibouta
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Patent number: 5561147Abstract: There is disclosed a pharmaceutical composition for providing antiinflammatory, antipyretic, analgesic, antiallergic, immunosuppressing or immunomodulating activity which comprises a pyridine derivative of the formula (I): ##STR1## wherein R is an optionally substituted pyridine ring, X is a oxygen atom or --S(O).sub.n --, wherein n is 0, 1 or 2, A is a bivalent C.sub.1-15 hydrocarbon residue whose branched moiety may have a substituent, Y is an oxygen or sulfur atom, R.sub.3 is a hydrogen atom or an optionally substituted hydrocarbon residue, R.sub.4 is an optionally substituted hydrocarbon residue or an optionally substituted monocyclic or bicyclic heterocyclic group, R.sub.3 and R.sub.4 may be joined together with the carbamoyl group or the thiocarbamoyl group to which they are attached to form an optionally substituted heterocyclic group, or R.sub.3 or R.sub.Type: GrantFiled: May 31, 1995Date of Patent: October 1, 1996Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Taketoshi Saijo, Kiminori Tomimatsu
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Patent number: 5457106Abstract: There is disclosed a pharmaceutical composition for providing antiinflammatory, antipyretic, analgesic, antiallergic, immunosuppressing or immunomodulating activity which comprises a pyridine derivative of the formula (I): ##STR1## wherein R is an optionally substituted pyridine ring, X is a oxygen atom or --S(O).sub.n --, wherein n is 0, 1 or 2, A is a bivalent C.sub.1-15 hydrocarbon residue whose branched moiety may have a substituent, Y is an oxygen or sulfur atom, R.sub.3 is a hydrogen atom or an optionally substituted hydrocarbon residue, R.sub.4 is an optionally substituted hydrocarbon residue or an optionally substituted monocyclic or bicyclic heterocyclic group, R.sub.3 and R.sub.4 may be joined together with the carbamoyl group or the thiocarbamoyl group to which they are attached to form an optionally substituted heterocyclic group, or R.sub.3 or R.sub.Type: GrantFiled: November 4, 1994Date of Patent: October 10, 1995Assignee: Takeda Chemical Industries, Ltd.Inventors: Muneo Takatani, Taketoshi Saijo, Kiminori Tomimatsu
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Patent number: 5395839Abstract: A calmodulin inhibitory composition containing a compound of the formula (I): ##STR1## as well as an angiogenesis inhibitory composition containing a compound of the formula (1): ##STR2## are disclosed.Type: GrantFiled: June 9, 1993Date of Patent: March 7, 1995Assignee: Takeda Chemical Industries, Ltd.Inventors: Takatani Muneo, Yoshio Kozai, Kiminori Tomimatsu, Yumiko Shibouta