Abstract: The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including a compound represented by the following formula (I) or a salt thereof: where: —A— represents —NH—, —S—, or —O—; R1 and R2 are identical to or different from each other, and each represent a hydrogen atom or an alkyl group; R3 represents a hydrogen atom, a halogen atom, or an alkyl group; R4 represents a hydrogen atom or an alkyl group; R5 represents a hydrogen atom or an alkyl group; R6 and R7 are identical to or different each other, and each represent a hydrogen atom, a halogen atom, or an alkyl group; and R6 and R7 may form an unsaturated hydrocarbon six-membered ring together with a carbon atom to which R6 is bonded and a carbon atom to which R7 is bonded.

Abstract: An object to be achieved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including at least one kind selected from the group consisting of mebendazole and itraconazole or a salt thereof.

Abstract: A primary object of the present invention is to provide a method for conveniently and accurately testing for pulmonary hypertension. To achieve this object, the present invention provides a method for testing for pulmonary hypertension using as an indicator the concentration of selenoprotein P protein in a sample derived from a subject.

Abstract: A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing a PPAR? agonist.

Abstract: A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing celastrol or a salt thereof.

Abstract: The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including a compound represented by the following formula (I) or a salt thereof: where: -A- represents —NH—, —S—, or —O—; R1 and R2 are identical to or different from each other, and each represent a hydrogen atom or an alkyl group; R3 represents a hydrogen atom, a halogen atom, or an alkyl group; R4 represents a hydrogen atom or an alkyl group; R5 represents a hydrogen atom or an alkyl group; R6 and R7 are identical to or different each other, and each represent a hydrogen atom, a halogen atom, or an alkyl group; and R6 and R7 may form an unsaturated hydrocarbon six-membered ring together with a carbon atom to which R6 is bonded and a carbon atom to which R7 is bonded.

Abstract: An object to be achieved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension, including at least one kind selected from the group consisting of mebendazole and itraconazole or a salt thereof.

Abstract: A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing emetine or a salt thereof.

Abstract: A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing an ingredient having a selenoprotein P activity-inhibiting action.

Abstract: A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing emetine or a salt thereof.

Abstract: A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing celastrol or a salt thereof.

Abstract: A problem to be solved by the present invention is to provide a novel preventive or therapeutic agent for pulmonary hypertension containing as an active ingredient a compound that has not been known for a therapeutic effect on pulmonary hypertension heretofore. The present invention provides a preventive or therapeutic agent for pulmonary hypertension containing an ingredient having a selenoprotein P activity-inhibiting action.

Abstract: A primary object of the present invention is to provide a method for conveniently and accurately testing for pulmonary hypertension. To achieve this object, the present invention provides a method for testing for pulmonary hypertension using as an indicator the concentration of selenoprotein P protein in a sample derived from a subject.

Abstract: An object of the present invention is to provide a novel examination method for a cardiovascular disease. As means for achieving the object, provided is an examination method for a cardiovascular disease, the method including the steps of: measuring a concentration of cyclophilin A protein in a human blood sample; and determining a probability of development of a cardiovascular disease based on the measured concentration of cyclophilin A protein.

Abstract: A primary object of the present invention is to provide a method for conveniently and accurately testing for pulmonary hypertension. To achieve this object, the present invention provides a method for testing for pulmonary hypertension using as an indicator the concentration of selenoprotein P protein in a sample derived from a subject.

Abstract: An object of the present invention is to provide a novel examination method for a cardiovascular disease. As means for achieving the object, provided is an examination method for a cardiovascular disease, the method including the steps of: measuring a concentration of cyclophilin A protein in a human blood sample; and determining a probability of development of a cardiovascular disease based on the measured concentration of cyclophilin A protein.

Abstract: It is an object of the present invention to provide a miniaturized, high-precision, easy, and low-cost dynamic pressure bearing device and a manufacturing method thereof. In manufacturing a dynamic pressure bearing device, a first and a second ring-shaped member are fixedly fitted to an outer peripheral surface of a rotating shaft member to constitute a rotating portion, an intermediate member is disposed between these members to constitute a fixed portion, a thrust bearing portion is formed in gaps between the first and second ring-shaped members and the intermediate member, and a journal bearing portion is formed in a gap between the rotating shaft member of the rotating portion and the intermediate member, the first and second ring-shaped members being fixed only with an adhesive applied on surfaces thereof which is to be fitted to the rotating shaft member.

Abstract: It is an object of the present invention to provide a miniaturized, high-precision, easy, and low-cost dynamic pressure bearing device and a manufacturing method thereof. In manufacturing a dynamic pressure bearing device, a first and a second ring-shaped member are fixedly fitted to an outer peripheral surface of a rotating shaft member to constitute a rotating portion, an intermediate member is disposed between these members to constitute a fixed portion, a thrust bearing portion is formed in gaps between the first and second ring-shaped members and the intermediate member, and a journal bearing portion is formed in a gap between the rotating shaft member of the rotating portion and the intermediate member, the first and second ring-shaped members being fixed only with an adhesive applied on surfaces thereof which is to be fitted to the rotating shaft member.

Abstract: It is an object of the present invention to provide a miniaturized, high-precision, easy, and low-cost dynamic pressure bearing device and a manufacturing method thereof. In manufacturing a dynamic pressure bearing device, a first and a second ring-shaped member are fixedly fitted to an outer peripheral surface of a rotating shaft member to constitute a rotating portion, an intermediate member is disposed between these members to constitute a fixed portion, a thrust bearing portion is formed in gaps between the first and second ring-shaped members and the intermediate member, and a journal bearing portion is formed in a gap between the rotating shaft member of the rotating portion and the intermediate member, the first and second ring-shaped members being fixed only with an adhesive applied on surfaces thereof which is to be fitted to the rotating shaft member.

Abstract: To manufacture a dynamic pressure bearing part at a low cost, capable of making consumption power small by reducing a load of rotation and having remarkable durability while ensuring small size and high performance. Dynamic pressure generating projection parts 21 are formed on the surface of an annular ring, which is a material of the dynamic pressure bearing part having a profile shape of a herringbone type having a first belt-like part 11L and a second belt-like part 11R which are branched out from a tip end 21S to a rear end so as to form a double fork shape, and widths of which are made to be approximately fixed widths. The material of the dynamic pressure bearing part is subjected to a magnetic barrel polish processing to obtain the dynamic pressure thrust bearing part.