Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

Abstract: A novel method for immunosuppressive in a mammal suffering from an immune disease, including administering to the mammal a therapeutically effective amount of a heterocyclic compound represented by the general formula (I) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is disclosed. A novel heterocyclic compound represented by the general formula (II) (wherein X or other variables are as defined in the specification) or a pharmaceutically acceptable salt thereof is also disclosed.

Abstract: Heterocyclic compounds of the formula: ##STR1## and a cardiotonic agent containing the same which have an excellent positive inotropic effect and which suppress increase of heart rate.

Abstract: The present invention relates to a novel heterocyclic compound having excellent positive inotropic effect as cardiotonic agent and suppressing increase of heart rate and a cardiotonic agent containing the novel heterocyclic compound as active component.

Abstract: A thiazole derivative represented by the formula I, pharmaceutically acceptable acid addition salt thereof, and a process for preparation thereof ##STR1## wherein R.sub.1 represents --COOR.sub.4, ##STR2## or cyano wherein R.sub.4 represents hydrogen or lower alkyl, andR.sub.5 and R.sub.6 may be the same or different and represent hydrogen, lower alkyl, aryl, amino-lower alkyl, N-lower alkylamino-lower alkyl, N,N-di-lower alkylamino-lower alkyl or R.sub.5 and R.sub.6 are joined to form a N-containing heterocyclic group;R.sub.2 represents hydrogen or lower alkyl; andR.sub.3 represents N-containing heterocyclic group.These compounds are useful as cardiotonic agents.

Abstract: A novel 1,4-thiazine derivative represented by the formula I, a pharmaceutically acceptable acid addition salt thereof, a process for preparation thereof and a cardiotonic agent comprising it as an effective component; ##STR1## wherein R.sub.1 and R.sub.2 represent respectively hydrogen atom, lower alkyl group, lower alkoxy group, amino group, lower alkyl-amino group, aryl-amino group, hydroxy group, aryl group or 5- or 6-membered heterocyclic residue;R.sub.3 and R.sub.4 represent hydrogen atom or lower alkyl group; andR.sub.5 represents N-containing heterocyclic residue and is not pyridinyl group when R.sub.1 and R.sub.2 represent hydrogen atom and R.sub.3 and R.sub.4 represent hydrogen atom or lower alkyl group.

Abstract: Disclosed is a novel 1,4-thiazine derivatives represented by the following general formula I and a pharmaceutically acceptable acid addition salt thereof: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 respectively represent a hydrogen atom or a lower alkyl group. Also disclosed are processes for preparation of a novel thiazine derivative represented by the general formula I, which comprise reacting a compound of the general formula III with a compound of the general formula A-X' in a compound containing a pyridinyl group as a solvent to obtain a compound of the general formula II: ##STR2## wherein R.sub.1, R.sub.2 and R.sub.

Abstract: A polysaccharide PS-A obtained from plants belonging to the genus Epimedium and having the following physicochemical properties, a process for preparation thereof and use as phylactic and immunostimulating agents comprising the polysaccharide PS-A as an effective component:1. Elementary analysis: C=40.92; H=6.17; Ash=very small;2. Molecular weight: 75,000.+-.25,000 (average molecular weight);3. Decomposition point: 205.degree. C.;4. pH: 7.0 (solution of 100 mg of PS-A in 50 ml of water);5. Specific rotatory power: [.alpha.].sub.D.sup.19 =-23.6.degree. (in H.sub.2 O, c=0.527);6. Infrared absorption spectrum: .nu..sub.max.sup.KBr (cm.sup.-1)/3400, 2900, 1620, 1400, 1230, 1060;7. Ultraviolet absorption spectrum: Maximum absorption is not recognized in the range of 240-400 nm.;8. Outward form: White or faint brown, amorphous powder;9. Solubility:(a) Soluble in water;(b) Insoluble in methanol, ethanol, acetone, ethyl acetate, diethyl ether, hexane and chloroform;10.

Abstract: The present invention provides an extract obtained by extracting a plant belonging to the genus Epimedium sp. with a mixed solvent of water and a water-miscible organic solvent or with water, defatting the obtained aqueous extract and collecting a high-molecular compounds-containing fraction from the defatted aqueous extract, a process for preparation of this extract, an antibacterial agent comprising this extract as an effective component and an antibacterial therapy by using this extract.