Patents by Inventor Kimiyasu Shiraki
Kimiyasu Shiraki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150166639Abstract: The invention provides agents that promote or inhibit neurite elongation comprising as an active ingredient an antibody that recognizes a varicella-zoster virus immediate-early protein and cross-reacts with a brain-derived neurotrophic factor. The invention also provides methods of utilizing such agents to prevent or treat a nervous disease or a disease with nerve hypersensitivity caused by a condition selected from the group consisting of postherpetic neuralgia, chronic pains, experience-dependent social aversion and stress.Type: ApplicationFiled: February 26, 2015Publication date: June 18, 2015Inventors: Kimiyasu SHIRAKI, Yuka HAMA, Yoshihiro YOSHIDA, Masaaki TSUDA, Tadaharu TSUMOTO, Shunro ENDO, Michiaki TAKAHASHI
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Patent number: 8637539Abstract: The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.Type: GrantFiled: August 18, 2005Date of Patent: January 28, 2014Assignee: Toray Industries, Inc.Inventors: Hiroshi Nagase, Takashi Endo, Kuniaki Kawamura, Toshiaki Tanaka, Tomohiko Suzuki, Tsutomu Suzuki, Yasushi Kuraishi, Kimiyasu Shiraki
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Patent number: 8101553Abstract: An antibody library is prepared by selecting a light chain variable region capable of binding to the variable region of heavy chain to reproduce an active conformation and using the same. Because of being capable of maintaining the diversity of the heavy chain variable region at a high ratio in vitro, the antibody library of the present invention is expected as enabling the acquisition of antibodies with various binding activities.Type: GrantFiled: February 22, 2001Date of Patent: January 24, 2012Assignee: Medical & Biological Laboratories Co., Ltd.Inventors: Yoshikazu Kurosawa, Yasushi Akahori, Yoshitaka Iba, Kazuhiko Morino, Midori Shinohara, Motohide Takahashi, Yoshinobu Okuno, Kimiyasu Shiraki
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Patent number: 7731955Abstract: An interleukin-6 suppressive agent comprising lactoperoxidase as an active ingredient is used as a pharmaceutical preparation or the like for prevention and/or therapy of a disease caused by production of interleukin-6, such as thrombocytosis, myeloma, Castleman syndrome, rheumatoid arthritis, or influenza-virus infectious disease.Type: GrantFiled: September 13, 2007Date of Patent: June 8, 2010Assignee: Morinaga Milk Industry Co., Ltd.Inventors: Kimiyasu Shiraki, Masahiko Kurokawa, Yoshitaka Tamura, Koji Yamauchi, Hiroyuki Wakabayashi, Kouichirou Shin
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Publication number: 20100047247Abstract: The invention provides agents that promote or inhibit neurite elongation comprising as an active ingredient an antibody that recognizes a varicella-zoster virus immediate-early protein and cross-reacts with a brain-derived neurotrophic factor. The invention also provides methods of utilizing such agents to prevent or treat a nervous disease or a disease with nerve hypersensitivity caused by a condition selected from the group consisting of postherpetic neuralgia, chronic pains, experience-dependent social aversion and stress.Type: ApplicationFiled: November 16, 2007Publication date: February 25, 2010Applicant: THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITYInventors: Kimiyasu Shiraki, Yuka Hama, Yoshihiro Yoshida, Masaaki Tsuda, Tadaharu Tsumoto, Shunro Endo, Michiaki Takahashi
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Publication number: 20080160005Abstract: An interleukin-6 suppressive agent comprising lactoperoxidase as an active ingredient is used as a pharmaceutical preparation or the like for prevention and/or therapy of a disease caused by production of interleukin-6, such as thrombocytosis, myeloma, Castleman syndrome, rheumatoid arthritis, or influenza-virus infectious disease.Type: ApplicationFiled: September 13, 2007Publication date: July 3, 2008Inventors: Kimiyasu Shiraki, Masahiko Kurokawa, Yoshitaka Tamura, Koji Yamauchi, Hiroyuki Wakabayashi, Kouichirou Shin
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Patent number: 7282202Abstract: An interleukin-6 suppressive agent comprising lactoperoxidase as an active ingredient is used as a pharmaceutical preparation or the like for prevention and/or therapy of a disease caused by production of interleukin-6, such as thrombocytosis, myeloma, Castleman syndrome, rheumatoid arthritis, or influenza-virus infectious disease.Type: GrantFiled: November 25, 2003Date of Patent: October 16, 2007Assignee: Morinaga Milk Industry Co., Ltd.Inventors: Kimiyasu Shiraki, Masahiko Kurokawa, Yoshitaka Tamura, Koji Yamauchi, Hiroyuki Wakabayashi, Kouichirou Shin
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Publication number: 20060094741Abstract: The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R3, R4, R5, R6, R7, R8, A, and B have the same definitions as those described in the specification), and an animal model produced by administering (+)-4a-(3-hydroxyphenyl)-2-methyl-1,2,3,4,4a,5,12,12a-octohydro-trans-quinolino[2,3-g]isoquinoline. The present invention makes it possible to perform drug treatment for neuropathic pain. The therapeutic effect of a compound against neuropathic pain can also be evaluated.Type: ApplicationFiled: August 18, 2005Publication date: May 4, 2006Applicant: Toray Industries, Inc., a corporation of JapanInventors: Hiroshi Nagase, Takashi Endo, Kuniaki Kawamura, Toshiaki Tanaka, Tomohiko Suzuki, Tsutomu Suzuki, Yasushi Kuraishi, Kimiyasu Shiraki
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Publication number: 20050249715Abstract: An interleukin-6 suppressive agent comprising lactoperoxidase as an active ingredient is used as a pharmaceutical preparation or the like for prevention and/or therapy of a disease caused by production of interleukin-6, such as thrombocytosis, myeloma, Castleman syndrome, rheumatoid arthritis, or influenza-virus infectious disease.Type: ApplicationFiled: November 25, 2003Publication date: November 10, 2005Inventors: Kimiyasu Shiraki, Masahiko Kurokawa, Yoshitaka Tamura, Koji Yamauchi, Hiroyuki Wakabayashi, Kouichirou Shin
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Patent number: 5849476Abstract: The present invention provides a recombinant varicella-zoster virus prepared by inserting, into the viral genome, nucleic acids from the hepatitis B virus genome, a genomic DNA of the recombinant varicella-zoster virus, a live vaccine containing the recombinant varicella-zoster virus as an effective ingredient, an antigen derived from the recombinant varicella-zoster virus, and diagnostic agent containing the antigen.The recombinant varicella-zoster virus of the present invention can be utilized as a multivalent vaccine having an excellent immunity effect both on chicken pox and hepatitis B, and expression products and genomic DNA thereof may be used as a multivalent diagnostic agent.Type: GrantFiled: March 13, 1997Date of Patent: December 15, 1998Assignee: The Research Foundation for Microbial Diseases of Osaka UniversityInventors: Kimiyasu Shiraki, Michiaki Takahashi
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Patent number: 5653976Abstract: The present invention provides a recombinant varicella-zoster virus prepared by inserting into the viral genome, nucleic acids from hepatitis B virus genome, a genomic DNA of the recombinant varicella-zoster virus, a live vaccine containing the recombinant varicella-zoster virus as an effective ingredient, an antigen derived from the recombinant varicella-zoster virus, and diagnostic agent containing the antigen. The recombinant varicella-zoster virus of the present invention can be utilized as a multivalent vaccine having an excellent immunity effect both on chickenpox and hepatitis B, and the expression products and genomic DNA thereof may be used as a multivalent diagnostic agent.Type: GrantFiled: November 15, 1994Date of Patent: August 5, 1997Assignee: The Research Foundation for Microbial Diseases of Osaka UniversityInventors: Kimiyasu Shiraki, Michiaki Takahashi
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Patent number: 5411733Abstract: Antiviral agent containing a crude drug effective on a broad range of viruses.Type: GrantFiled: April 26, 1993Date of Patent: May 2, 1995Inventors: Toyoharu Hozumi, Takao Matsumoto, Haruo Ooyama, Tsuneo Namba, Kimiyasu Shiraki, Masao Hattori, Masahiko Kurokawa, Shigetoshi Kadota