Publication number: 20090082352
Abstract: A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halo(lower alkyl) group, cyano group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7, R8, R9 and R10 represent hydrogen atom, a halogen atom, a lower alkyl group, a halo(lower alkyl) group and the like, R11 and R12 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl) (lower alkyl) group and the like, and R13 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).
Type:
Application
Filed:
April 10, 2008
Publication date:
March 26, 2009
Applicant:
KOWA COMPANY, LTD.
Inventors:
Tadaaki OHGIYA, Toru MIURA, Ayumu OKUDA, Toshiharu ARAI, Koichi YAMAZAKI, Taro AOKI, Katsutoshi MIYOSAWA, Haruki SHIBATA, Kimiyuki SHIBUYA
Publication number: 20090062306
Abstract: A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7 and R8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R10 and R11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).
Type:
Application
Filed:
March 11, 2008
Publication date:
March 5, 2009
Applicant:
KOWA COMPANY, LTD.
Inventors:
Tadaaki OHGIYA, Toru MIURA, Ayumu OKUDA, Toshiharu ARAI, Koichi YAMAZAKI, Taro AOKI, Katsutoshi MIYOSAWA, Haruki SHIBATA, Kimiyuki SHIBUYA
Publication number: 20090054474
Abstract: A compound represented by the following general formula (I) or a salt thereof, or a solvate thereof: (wherein R1, R2, R3, R4 and R5 are the same or different, and represent hydrogen atom, a halogen atom, a lower alkyl group etc., R6, R7 and R8 are the same or different, and represent hydrogen atom, a halogen atom, a lower alkyl group etc., R9 and R10 are the same or different, and represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group etc., and R11 represents hydrogen atom, a halogen atom, a lower alkoxy group, a (lower alkyl)thio(lower alkoxy) group, a (lower alkyl)sulfinyl(lower alkoxy) group, a (lower alkyl)sulfonyl(lower alkoxy) group etc.), which has potent inhibitory activity on CETP.
Type:
Application
Filed:
August 7, 2007
Publication date:
February 26, 2009
Applicant:
Kowa Company, Ltd.
Inventors:
Tadaaki OHGIYA, Toru MIURA, Ayumu OKUDA, Toshiharu ARAI, Koichi YAMAZAKI, Taro AOKI, Katsutoshi MIYOSAWA, Haruki SHIBATA, Kimiyuki SHIBUYA