Abstract: The present invention provides a method for suppressing mannitol-induced protein aggregation by providing sucrose to a liquid formulation containing a protein. The present invention also provides methods for storing and preparing a liquid formulation containing a protein and a combination of mannitol and sucrose such that the presence of sucrose suppresses mannitol-induced protein aggregation.

Abstract: The present invention provides a method for inhibiting mannitol-induced aggregation of a protein in a liquid formulation by increasing the protein concentration to an amount greater than 50 mg/ml. The present invention also provides methods for storing and preparing a liquid formulation containing mannitol and a protein concentration greater than 50 mg/ml.

Abstract: A toner cartridge including a container body having a discharge opening. A drive transmitting member is fixedly coupled with the container body near the discharge opening. The drive transmitting member is sized and shaped to transmit rotational movement to the container body. A collar is moveably coupled along the container body, and the collar closes the discharge opening in a first position, and opens the discharge opening in a second position. The cartridge further includes, in one example, a biasing element sized and shaped to bias the collar toward the first position. In another example, the drive transmitting member includes at least one deflectable support member, and the deflectable support member includes a ramped drive element. The ramped drive element includes a first ramp face, a second ramp face, and at least one driving face. Optionally, the first and second ramp faces are sloped with respect to the support member.