Abstract: The invention provides compositions and methods for treating optic neuropathic disorders.

Abstract: A method of treating an ocular nerve injury in a subject in need thereof, the method comprising administering a therapeutically effective amount of baicalein or an analog thereof.

Abstract: The invention provides compositions and methods for treating optic neuropathic disorders.

Abstract: The invention provides compositions and methods for preserving, restoring, or enhancing vision of a subject by administering compositions to an injured or diseased eye.

Abstract: A method of treating an ocular nerve injury in a subject in need thereof, the method comprising administering a therapeutically effective amount of baicalein or an analog thereof.

Abstract: Compositions and methods for treating and/or reducing risk of development or progression of neuroinflammation and neurodegeneration, comprising HSP60 e.g., for nasal administration, and IGFBPL1, e.g., for nasal, systemic, or ocular, e.g., intravitreal, administration.

Abstract: Methods, systems, and devices are provided for assessing visual function, especially in animals. For example, a device can be used for assessing visual functions, such as PLR and OMR, in animals that includes a visual stimulus unit. The device can also include one or more input devices that include at least one camera that is configured to monitor movement of the test subject and a processor that is configured to analyze the movement of the test subject taken by the camera and to assess visual functions of the test subject. The device can be used in a system including a designated general location for the test subject in which the test subject can see the visual stimulus unit and move freely while being monitored by the camera.

Abstract: The invention provides compositions and methods for preserving, restoring, or enhancing vision of a subject by administering compositions to an injured or diseased eye.

Abstract: The invention provides compositions and methods for treating optic neuropathic disorders.

Abstract: The invention provides compositions and methods for preserving, restoring, or enhancing vision of a subject by administering compositions to an injured or diseased eye.

Abstract: The invention provides compositions and methods for preserving, restoring, or enhancing vision of a subject by administering compositions to an injured or diseased eye.

Abstract: Provided herein are methods and compositions for rendering a cellular environment permissive to axon regeneration and neural cell transplantation. Methods for stimulating axon regeneration in adult subjects are also disclosed. The methods may comprise contacting a tissue with an agent that prevents glial scar formation, such as by inhibiting reactive astroglial cells, and optionally an agent that increases bcl-2 protein levels in neural cells. Exemplary agents include astrotoxin for inhibiting reactive astroglial cells and lithium for increasing bcl-2 protein levels.