Patents by Inventor Kin Sing Lee

Kin Sing Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted piperidines as soluble epdxide hydrolase inhibitors
    Patent number: 9850207
    Abstract: Provided are methods for treating, reducing, alleviating, and/or inhibiting neuropathic pain by orally, intravenously or intrathecally administering an effective amount of an inhibitor of soluble epoxide hydrolase (“sEH”), to a patient in need thereof. The neuropathic pain treated is selected from the group consisting of post-herpetic neuralgia, trigeminal neuralgia, focal peripheral nerve injury, and anesthesia dolorosa, central pain due to stroke or mass lesion, spinal cord injury, or multiple sclerosis, and peripheral neuropathy due to diabetes, HIV, or chemotherapy.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: December 26, 2017
    Assignee: The Regents of the University of California
    Inventors: Bruce D. Hammock, Kin Sing Lee, Bora Inceoglu, Karen Wagner
  • Colorimetric and fluorescent proteins
    Patent number: 9732127
    Abstract: The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: August 15, 2017
    Assignee: Board of Trustees of Michigan State University
    Inventors: Babak Borhan, James Geiger, Wenjing Wang, Chrysoula Vasileiou, Kin Sing Lee, Tetyana Berbasova
  • ACYL PIPERIDINE INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
    Publication number: 20160200683
    Abstract: Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
    Type: Application
    Filed: March 21, 2016
    Publication date: July 14, 2016
    Inventors: Bruce D. Hammock, Tristan Rose, Christophe Morisseau, Kin Sing Lee
  • COLORIMETRIC AND FLUORESCENT PROTEINS
    Publication number: 20160115210
    Abstract: The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.
    Type: Application
    Filed: October 15, 2015
    Publication date: April 28, 2016
    Inventors: Babak Borhan, James Geiger, Wenjing Wang, Chrysoula Vasileiou, Kin Sing Lee, Tetyana Berbasova
  • Acyl piperidine inhibitors of soluble epoxide hydrolase
    Patent number: 9296693
    Abstract: Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: March 29, 2016
    Assignee: The Regents of the University of California
    Inventors: Bruce D. Hammock, Tristan Rose, Christophe Morisseau, Kin Sing Lee
  • Colorimetric and fluorescent proteins
    Patent number: 9169305
    Abstract: The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.
    Type: Grant
    Filed: March 23, 2011
    Date of Patent: October 27, 2015
    Assignee: Board of Trustees of Michigan State University
    Inventors: Babak Borhan, James Geiger, Wenjing Wang, Chrysoula Vasileiou, Kin Sing Lee, Tetyana Berbasova
  • Acyl piperidine inhibitors of soluble epoxide hydrolase
    Patent number: 9034903
    Abstract: Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases. In some embodiments, the present invention provides a method for monitoring the activity of a soluble epoxide hydrolase, the method including contacting the soluble epoxide hydrolase with an amount of a compound of the present invention sufficient to produce a detectable change in the fluorescence of the soluble epoxide hydrolase by interacting with one or more tryptophan residues present in the catalytic site of said sEH.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: May 19, 2015
    Assignee: The Regents of the University of California
    Inventors: Bruce D. Hammock, Kin Sing Lee, Christophe Morisseau
  • Treating Neuropathic Pain with Seh Inhibitors
    Publication number: 20150065540
    Abstract: Provided are methods for treating, reducing, alleviating, and/or inhibiting neuropathic pain by orally, intravenously or intrathecally administering an effective amount of an inhibitor of soluble epoxide hydrolase (“sEH”), to a patient in need thereof. The neuropathic pain treated is selected from the group consisting of post-herpetic neuralgia, trigeminal neuralgia, focal peripheral nerve injury, and anesthesia dolorosa, central pain due to stroke or mass lesion, spinal cord injury, or multiple sclerosis, and peripheral neuropathy due to diabetes, HIV, or chemotherapy.
    Type: Application
    Filed: February 1, 2013
    Publication date: March 5, 2015
    Inventors: Bruce D. Hammock, Kin Sing Lee, Bora Inceoglu, Karen Wagner
  • Acyl Piperidine Inhibitors of Soluble Epoxide Hydrolase
    Publication number: 20150011586
    Abstract: Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases. In some embodiments, the present invention provides a method for monitoring the activity of a soluble epoxide hydrolase, the method including contacting the soluble epoxide hydrolase with an amount of a compound of the present invention sufficient to produce a detectable change in the fluorescence of the soluble epoxide hydrolase by interacting with one or more tryptophan residues present in the catalytic site of said sEH.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 8, 2015
    Inventors: Bruce D. Hammock, Kin Sing Lee, Christophe Morisseau
  • COLORIMETRIC AND FLUORESCENT PROTEINS
    Publication number: 20130157284
    Abstract: The invention relates to intracellular lipid binding proteins that bind retinoids and/or dye ligands and that are modified to transmit or emit light at a variety of different wavelengths.
    Type: Application
    Filed: March 23, 2011
    Publication date: June 20, 2013
    Applicant: Board of Trustees of Michigan State University
    Inventors: Babak Borhan, James Geiger, Wenjing Wang, Chrysoula Vasileiou, Kin Sing Lee, Tetyana Berbasova
  • ACYL PIPERIDINE INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE
    Publication number: 20130143925
    Abstract: Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases.
    Type: Application
    Filed: January 28, 2011
    Publication date: June 6, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Bruce D. Hammock, Tristan Rose, Christophe Morisseau, Kin Sing Lee