Abstract: Provided are methods of sensitizing LKB1/STK11 deficient cancers to immune therapy. A method for treatment for LKB1/STK11 deficient cancers is provided comprising administration of inhibitor or inhibitors of one or more of NAMPT, CD38, SHP2, CXCR1/2, HDAC4 and PARP in combination with immunotherapy.

Abstract: A biochemical analysis system capable of sample preparation and processing can include at least one inlet channel having a non-fouling, slippery surface to autonomously transport a fluid sample to a chamber by a geometry of the at least one inlet channel. The at least one inlet channel can include a first end, which is open and exposed, and a second end connected to the chamber for mixing and reaction of the fluid sample, and the at least one inlet channel can include a converging or diverging angle.

Abstract: A power tool system including a power tool and a base. The power tool has a housing, a motor, and a chuck. The housing supports or is connected to a power source. The motor is supported by and disposed in the housing and includes an output shaft. The motor is configured to drive rotation of the output shaft. The chuck is coupled to the output shaft for rotation with the output shaft. The chuck is configured to receive a tool bit configured to perform an operation. The base is engageable by the power tool. Positioning the power tool in alignment with the base or in engagement with the base is configured to stop rotation of the chuck.

Abstract: The present invention provides methods of treating cancer by combination therapy with CDK4/6 inhibitors and immune checkpoint inhibition.

Abstract: There is disclosed a floor cleaning apparatus. The apparatus has a cleaning head portion for engaging a floor surface during cleaning, an upstanding portion for maneuvering movement of the cleaning head portion, a liquid delivery assembly, a handle portion extending from the upstanding portion and a sealed liquid storage container. The assembly includes a single needle defining a first passageway for allowing cleaning detergent from the sealed storage container to travel to the cleaning head portion therethrough and a second passageway for allowing as or air to travel from the surrounding to the sealed storage container for pressure equalization, and wherein the needle has a non-cylindrical configuration and a flattened configuration.

Abstract: Systems and methods are provided for interpreting a correlation model that predicts a correlation between a pair of data corresponding to a pair of incident tickets using an interpreter model. The correlation model includes a Siamese Network including a plurality of neural networks. The interpreter model, trained by using training data, represents a student model (a glass-box model) while the correlation model, trained using the training data, represents a more complex teacher model (a black-box mode) of a teacher-student model. The present disclosure generates global feature importance scores based on the trained interpreter model, which indicates a degree of influence of a feature compared to other features in incident data in determining correlations, to generate additional training data emphasizing influential features and to retrain the correlation model.

Abstract: There is disclosed a floor cleaning apparatus. The apparatus has a cleaning head portion for engaging a floor surface during cleaning, an upstanding portion for maneuvering movement of said cleaning head portion, a liquid delivery assembly, a handle portion extending from said upstanding portion and a sealed liquid storage container. The cleaning head portion includes a first nozzle and a second nozzle arranged on lateral opposite ends for forward discharging of cleaning detergent therefrom. The liquid delivery assembly is configured to prevent, or at least minimize, undesirable leaking from the nozzles regardless of the orientation of the apparatus or the assembly.

Abstract: A wheel attachment for a garden tool comprises a guide wheel, and a wheel mounting frame on which the guide wheel is rollably mounted and which is detachably fixed to a guard of the garden tool. The wheel mounting frame comprises a fixing portion, which delimits a groove for accommodating an edge of the guard, and the edge of the guard is clamped by the fixing portion when the wheel mounting frame is fixed to the guard.

Abstract: An automated retail store system for providing automated storage of multiple items and scheduled handling of a customer order for said items at a single retail site, including: a store control system adapted to operate under the control of control signals generated based on order information for an order by a customer, said order information including information representing one or more items and a pickup time; a plurality of storage channels for storing different respective items; a retrieval system adapted to operate under the control of said store control system to: retrieve a plurality of said items in said order information from said channels, and place a plurality of said retrieved items into a delivery container; a conveyor system adapted to operate under the control of said store control system to: move said delivery container to either a storage rack or a locker compartment based on said pickup time, and move said delivery container from said storage rack to an available said locker compartment base

Abstract: A garden tool includes a drive shaft, a driven implement, and a locking cap configured to removably secure the drive shaft and the driven implement relative to each other. The locking cap is self-locking to inhibit loosening. The locking cap may include a ratchet mechanism. The garden tool may include a vegetation cutter.

Abstract: A power tool assembly includes a hand-held power tool, a dust collector removably coupled to the power tool, and first and second power tool battery packs each of which is interchangeably coupled with the power tool and the dust collector for separately powering the power tool and the dust collector, respectively.

Abstract: A method for training a neural network for linking incident management tickets is provided. A first training set of linked pairs of incident management tickets is generated. Each pair is labeled as being linked and comprises first and second tickets having first text features and second features. A Siamese neural network model is trained using the first text features as inputs to an input layer of the model. The input layer is configured to generate first and second input embeddings for the first and second tickets, respectively. The model is trained using the first and second input embeddings and the second features as inputs to an output layer of the model. The output layer is configured to generate first and second output embeddings for the first and second tickets, respectively. The model is trained using a contrastive loss function between the first and second output embeddings.

Abstract: The present disclosure provides methods and compositions related to combination therapy of a CDK7 inhibitor and immunotherapy. The combination of the CDK7 inhibitor and immunotherapy is useful in treating and/or preventing cancer in a subject. The combination therapy may further comprise chemotherapy (e.g., chemotherapeutic agents).

Abstract: The present invention is based on the identification of novel biomarkers predictive of responsiveness to anti-immune checkpoint inhibitor therapies.

Abstract: Provided is a method for treatment of lung squamous cell carcinoma (LUSC) by administering to an individual in need of treatment one or more inhibitors of the RTK-Ras signaling pathway. The LUSC cells may carry a mutation in a KMT2D gene. The inhibitors of the RTK-Ras signaling pathway are SHP2 inhibitors or epidermal growth factor receptor (EGFR) inhibitors. Combinations of the SHP2 inhibitors and EGFR inhibitors can be used.

Abstract: Provided are methods for cancer therapy. The method comprises inhibiting the expression and/or activity of ATF7IP and/or SETDB1 in cancer cells. Also provided is a method for identifying individuals for cancer therapy that includes using ATF7IP and/or SETDB1 inhibition.

Abstract: The present invention provides methods for treating cancer using combinations of bromodomain and extra-terminal (BET) protein inhibitors and certain chemotherapeutic drugs.