Abstract: A floor cleaning apparatus. The apparatus has a cleaning head portion for engaging a floor surface during cleaning, an upstanding portion for maneuvering movement of the cleaning head portion, a liquid delivery assembly, a handle portion extending from the upstanding portion and a sealed liquid storage container. The assembly includes a single needle defining a first passageway for allowing cleaning detergent from the sealed storage container to travel to the cleaning head portion therethrough and a second passageway for allowing as or air to travel from the surrounding to the sealed storage container for pressure equalization, and wherein the needle has a non-cylindrical configuration and a flattened configuration.

Abstract: A set of incident records are received for a computing system. The incident records are analyzed to identify similar incident records which are then linked. Incident clusters are generated based upon the links and incident records in each cluster are ranked. A prompt is generated to an artificial intelligence (AI) model based on the ranked, related incidents and the AI model returns a response that identifies a root cause and mitigation steps corresponding to the ranked incidents.

Abstract: A mobile automated container handling device and a method for handling a stack of a plurality of storage containers are disclosed.

Abstract: A noise-reduced and quietly operable electrically driven toothbrush with a technically simple basic structure includes a handle portion at a first end of the toothbrush and a head portion at a second end of the toothbrush. The head portion is detachably connectable to the handle portion. A rotatable drive shaft extends at least in the head portion and defines a first longitudinal axis. An electric drive unit directly or indirectly rotates the drive shaft. A bristle holder is pivotally mounted to the head portion and is drivingly engaged by an end of the drive shaft.

Abstract: This application relates to methods for overcoming or preventing resistance of a KRAS mutant cancer cell to a growth inhibition and/or cell death induction by a KRAS inhibitor or a SHP2 inhibitor, as well as to methods for enhancing sensitivity of a KRAS mutant cancer cell to a KRAS inhibitor or a SHP2 inhibitor. The application further relates to methods of treating a KRAS mutant cancer in a subject, the method comprising administering to the subject an effective amount of a KRAS inhibitor or a SHP2 inhibitor and an inhibitor of expression or function or a degrader or a binding partner of one or more of various proteins described herein. Related pharmaceutical compositions and kits are also disclosed.

Abstract: An automated retail store system, including: a store control system controlled by signals generated based on order information for a customer including information representing items and a pickup time; storage shelf units with internal portions having different predefined modular configurations, for storing a removable storage container; locker units with internal portions for providing a locker compartment; item retrieval systems controlled by said store control system to retrieve ordered items from storage containers, place those items into a delivery container, which is then placed into a locker compartment; and a verification system adapted to operate under the control of said store control system for verifying the customer's identity or unique identifier for said order.

Abstract: Provided are devices and methods for detecting the presence, absence, and/or characteristics of bacteria. A microfluidic device for characterizing bacteria is provided. The device contains one or more bacteria trapping channels, and one or more pneumatic channels in contact with the bacteria trapping channels, wherein the one or more pneumatic channels are configured to reduce the height of the one or more bacteria trapping channels to thereby trap bacteria in the one or more bacteria trapping channels if said bacteria are present in a liquid biological sample that is introduced into the microfluidic device. Also provided is a method for identifying bacteria that may be used with the microfluidic device.

Abstract: There is disclosed a floor cleaning apparatus. The apparatus has a cleaning head portion for engaging a floor surface during cleaning, an upstanding portion for maneuvering movement of the cleaning head portion, a liquid delivery assembly, a handle portion extending from the upstanding portion and a sealed liquid storage container. The assembly includes a single needle defining a first passageway for allowing cleaning detergent from the sealed storage container to travel to the cleaning head portion therethrough and a second passageway for allowing as or air to travel from the surrounding to the sealed storage container for pressure equalization, and wherein the needle has a non-cylindrical configuration and a flattened configuration.

Abstract: The present disclosure provides a material composition, comprising: i) hydroxyl-termination polymer cross-linked by a boron compound; and ii) thermoplastic. The present disclosure also provides a method of producing the material composition. The material composition of the present invention comprises hydroxyl-termination polymer cross-linked by a boron compound which can make the material stretchable and non-sticky. Then thermoplastic was used to improve the stretch ability and make it easy for moulding.

Abstract: Disclosed is a treatment agent and a method for improving attractiveness of insects or their larvae to aquaculture animals. The treatment agent described in the present disclosure comprises at least one selected from the group consisting of nitrate and nitrite, and at least one selected from the group consisting of ascorbic acid, isoascorbic acid, tea polyphenols and nicotinamide. The treatment method comprises the following steps: washing the insects or their larvae; soaking the washed insects or their larvae in a solution of the treatment agent described in the present disclosure to obtained soaked insects or their larvae; and taking the soaked insects or their larvae out for draining water to obtain treated insects or their larvae. The treatment method of the present disclosure can kill pathogens in insects and fix the hemoglobin of insects, and improve the attractiveness and palatability of the obtained insects or their larvae.

Abstract: The subject matter of the present disclosure generally relates to techniques for isolating bacterial cells from a biological sample comprising red blood cells. Using an aggregating agent and an anticoagulant during sedimentation permits separation of bacterial pathogens in the sample from red blood cells. The separated sedimentation layer, which is enriched in any bacterial pathogens, can be centrifuged and resuspended to concentrate the bacteria for additional analysis, such as bacterial identification and/or antibiotic susceptibility tests.

Abstract: Provided are methods for treatment of cancer by administering to an individual who has a cancer that includes cancer cells that have an LKBI mutation an anti-CD38 agent, an inhibitor of EP300, or a combination thereof. Methods are also provided for treating an individual who has a cancer that includes cancer cells that do not have an LKBI mutation a Salt-Inducible Kinase (SIK) inhibitor and an anti-CD38 agent. The SIK inhibitors sensitizes the cancer cells that do not have the LKBI mutation to the anti-CD38 agent.

Abstract: Systems and methods which provide force amplified fastener assemblies configured for use with respect to detachable implements for power tools are described. Force amplified fastener assemblies may implement various gear train configurations for giving a mechanical advantage with respect to manual manipulation of the fastener assembly. A force amplified fastener assembly may include a lock mechanism operative to lock and/or unlock the force amplified fastener assembly and thus a fastening element thereof. Force amplified fastener assemblies of embodiments of the inventions may be utilized in place of conventional lock nut for affixing detachable implements to power tools.

Abstract: Systems and methods which provide force amplified fastener assemblies configured for use with respect to detachable implements for power tools are described. Force amplified fastener assemblies may implement various gear train configurations for giving a mechanical advantage with respect to manual manipulation of the fastener assembly. A force amplified fastener assembly may include a lock mechanism operative to lock and/or unlock the force amplified fastener assembly and thus a fastening element thereof. In some examples, a force amplified fastener assembly may include a grasping member assembly for facilitating manual application of torque. Additionally or alternatively, a force amplified fastener assembly may include a removable and replaceable external surface covering configured to protect at least a portion of the force amplified fastener assembly.

Abstract: Provided are methods of sensitizing LKB1/STK11 deficient cancers to immune therapy. A method for treatment for LKB1/STK11 deficient cancers is provided comprising administration of inhibitor or inhibitors of one or more of NAMPT, CD38, SHP2, CXCR1/2, HDAC4 and PARP in combination with immunotherapy.

Abstract: A biochemical analysis system capable of sample preparation and processing can include at least one inlet channel having a non-fouling, slippery surface to autonomously transport a fluid sample to a chamber by a geometry of the at least one inlet channel. The at least one inlet channel can include a first end, which is open and exposed, and a second end connected to the chamber for mixing and reaction of the fluid sample, and the at least one inlet channel can include a converging or diverging angle.