Abstract: Provided herein are compositions and methods for mechanochemical dynamic therapy.

Abstract: Provided herein are compositions and methods for remotely and non-invasively subjecting targeted biological structures with light emissions or chromogenic changes.

Abstract: Provided herein are compositions and methods for mechanochemical dynamic therapy.

Abstract: Provided herein are compositions and methods for remotely and non-invasively subjecting targeted biological structures with light emissions or chromogenic changes.

Abstract: A method of increasing blood-brain barrier permeability of selected brain tissue in a subject in need thereof is carried out by: (a) parenterally administering to the subject stem cells that migrate to the brain tissue, the stem cells containing a recombinant nucleic acid, the recombinant nucleic acid comprising a nucleic acid encoding a barrier-opening protein or peptide operably associated with a heat-inducible promoter; and then (b) selectively heating the selected brain tissue sufficient to induce the expression of the barrier-opening protein or peptide in an amount effective to increase the permeability of the blood-brain barrier in the selected brain tissue. Nucleic acids, vectors, stem cells and compositions useful for carrying out such methods are also described.

Abstract: An isolation system with imaging or radiation therapy capability is disclosed. At least one containment barrier (14, 15, 16, 17) defines an isolation region (10). An imaging or therapy system (20) is disposed outside of the isolation region. The containment barrier includes a substantially hollow tubular extension (24, 42, 44, 124, 224, 324) protruding away from the isolation region (10). The substantially hollow tubular extension surrounds an interior volume (26) that is in fluid communication with the isolation region and is in fluid isolation from the imaging or therapy system. The substantially hollow tubular extension is made at least partially of a material providing operative communication between the imaging or therapy system and the interior volume of the substantially hollow tubular extension.

Abstract: A tissue is imaged to detect the presence of amyloid deposits or other target proteins prior to their aggregation into plaques, with the assistance of the administration of a labeled bifunctional compound of which one functionality binds to the target protein and the second functionality binds to a chaperone protein that is present in the tissue of interest. The two functionalities have different binding affinities, the target-binding functionality having the greater binding affinity, with the result that the bifunctional compound preferentially remains in the tissue when bound to the chaperone and then the target protein while bifunctional compound that is not bound to the target protein will leave the tissue.

Abstract: Disclosed are methods for reconstructing a three-dimensional image of an object's volume of interest using computed tomography that employs conical-beam, intensity-modulated projections of this object. In one embodiment, a plurality of collimating devices serves to modulate the aperture of the radiation source thereby acting to modulate the intensity of the source upon the object. Also provided are image processing devices, examination apparatus, as well as a computer-readable medium and a program element adapted and configured to perform aspects of the methods disclosed herein.

Abstract: An isolation system with imaging or radiation therapy capability is disclosed. At least one containment barrier (14, 15, 16, 17) defines an isolation region (10). An imaging or therapy system (20) is disposed outside of the isolation region. The containment barrier includes a substantially hollow tubular extension (24, 42, 44, 124, 224, 324) protruding away from the isolation region (10). The substantially hollow tubular extension surrounds an interior volume (26) that is in fluid communication with the isolation region and is in fluid isolation from the imaging or therapy system. The substantially hollow tubular extension is made at least partially of a material providing operative communication between the imaging or therapy system and the interior volume of the substantially hollow tubular extension.

Abstract: Integrin receptor antagonists whose molecular structure includes a tetrahydropyridimidinylaminoethyloxybenzoyl group on a sulfonylamino-?-alanine nucleus exhibit increased binding affinity for the ?v?3 receptor when further substituted on the sulfonyl moiety with an N-amino alkycarbamyl group or a butyloxycarbonylamino alkylcarbamoyl group or similar groups.

Abstract: Polymerized liposome particles based upon lipids having a polymerizable functional group and a metal chelator to attach an imaging enhancement agent and lipids having an active targeting group to provide targeted polymerized liposome contrast agents. The polymerized imaging enhancement liposome particles interact with receptor targets holding the image enhancement agent to specific sites providing in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology.