Abstract: A retractable containment wall separates an imaging suite into two sections: a “hot” or contaminated section and a “cold” or non-contaminated section. The wall includes a center portion and retractable peripheral portions. Each retractable portion is made up of several panels. Between panels, between a panel and a room wall, and between a panel and the center portion are tongue and groove seals that mate to form seals at seams in the wall when the wall is deployed. Guide pins propagate along a guide track to facilitate transition of the portions between deployed and retracted orientations. The center portion includes a tube that extends into the imaging region of a diagnostic imaging device located in the non-contaminated portion of the imaging suite. The subject is inserted into the tube in preparation for an imaging procedure.

Abstract: A tissue is imaged to detect the presence of amyloid deposits or other target proteins prior to their aggregation into plaques, with the assistance of the administration of a labeled bifunctional compound of which one functionality binds to the target protein and the second functionality binds to a chaperone protein that is present in the tissue of interest. The two functionalities have different binding affinities, the target-binding functionality having the greater binding affinity, with the result that the bifunctional compound preferentially remains in the tissue when bound to the chaperone and then the target protein while bifunctional compound that is not bound to the target protein will leave the tissue.

Abstract: A retractable containment wall separates an imaging suite into two sections: a “hot” or contaminated section and a “cold” or non-contaminated section. The wall includes a center portion and retractable peripheral portions. Each retractable portion is made up of several panels. Between panels, between a panel and a room wall, and between a panel and the center portion are tongue and groove seals that mate to form seals at seams in the wall when the wall is deployed. Guide pins propagate along a guide track to facilitate transition of the portions between deployed and retracted orientations. The center portion includes a tube that extends into the imaging region of a diagnostic imaging device located in the non-contaminated portion of the imaging suite. The subject is inserted into the tube in preparation for an imaging procedure.

Abstract: A probe includes an ultrasound imaging transducer and a high intensity focused ultrasound (HIFU) transducer. The probe is operatively connected to a localizer which provides information indicative of the position and orientation of the probe in relation to a CT scanner. Information from the ultrasound imaging transducer and the CT scanner is used to assist in planning and performing a HIFU treatment.

Abstract: Enzyme-mediated intracellular trapping of a radionuclide in a target cell is achieved by transfecting the target cell with a transgenic vector encoding a microbial hydrogenase expressible in the target cell and exposing the transfected target cell with a radionuclide. The transgenically expressed microbial hydrogenase catalyzes the reduction of the radionuclide. The reduced radionuclide becomes trapped intracellularly where its emissions can be detected in radioscintigraphy applications. In addition, emissions from an intracellularly trapped radionuclide can be cytotoxic to the cell and therefore useful in radiotherapy applications. As a reporter, a microbial hydrogenase encoding nucleic acid can be included in a vector along with a transgene, both under the control of the same promoter. The detection of emissions from intracellularly reduced and trapped radionuclide can be used to monitor transgene expression.

Abstract: Integrin receptor antagonists whose molecular structure includes a tetrahydropyridimidinylaminoethyloxybenzoyl group on a sulfonylamino-?-alanine nucleus exhibit increased binding affinity for the ?v?3 receptor when further substituted on the sulfonyl moiety with an N-amino alkycarbamyl group or a butyloxycarbonylamino alkylcarbamoyl group or similar groups.

Abstract: Targeted tissue in vivo is altered using focused energy to specifically control endothelial permeability and interstitial integrity. Image guidance may be used in combination with physical energy deposition to facilitate the targeted delivery of materials. The method of the invention serves as a platform for delivering pharmaceutical agents, nucleic acids, proteins, liposomes, etc. to cells.