Patents by Inventor Kinji Iizuka
Kinji Iizuka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4870183Abstract: Novel amino acid derivatives useful as a therapeutic agent are disclosed. These amino acid derivatives and the pharmaceutically acceptable salts thereof have a human renin inhibitory effect when administered orally and are useful for treatment of hypertension, especially renin-associated hypertension.Type: GrantFiled: November 2, 1988Date of Patent: September 26, 1989Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Tetsuhiro Kubota, Kenji Akahane, Hideaki Umeyama, Yoshiaki Kiso
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Patent number: 4863904Abstract: Dipeptides are described which are represented by the formula ##STR1## wherein the various substituents are defined hereinbelow. These compounds have a strong inhibitory efect on human renin, and are useful as a therapeutically active agent for the treatment of hypertension, especially renin-associated hypertension.Type: GrantFiled: October 21, 1985Date of Patent: September 5, 1989Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Tetsuhiro Kubota, Kenji Akahane, Hideaki Umeyama, Yoshiaki Kiso
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Patent number: 4857650Abstract: New renin inhibitory amino acid derivatives represented by formula (I): ##STR1## wherein A represents an alkoxycarbonyl group having 2 to 7 carbon atoms, ##STR2## wherein R.sup.1 and R.sup.2 are defined as in the specification below or ##STR3## wherein X and Y are defined as in the specification herein below, n represents zero or one, Z represents --O-- or --NH--, and R represents a straight- or branched chain alkyl group having 1 to 7 carbon atoms, and pharmaceutically acceptable salts thereof, useful as a therapeutic agent are disclosed. The amino acid derivatives have a renin inhibitory effect when administered orally and are useful for treatment of hypertension, especially renin-associated hypertension.Type: GrantFiled: June 27, 1986Date of Patent: August 15, 1989Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Tetsuhiro Kubota, Kenji Akahane, Hideaki Umeyama, Yoshiaki Kiso
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Patent number: 4853463Abstract: Novel amino acid derivatives useful as a therapeutic agent are disclosed. These amino acid derivatives and the pharmaceutically acceptable salts thereof have a human renin inhibitory effect when administered orally and are useful for treatment of hypertension, especially renin-associated hypertension.Type: GrantFiled: December 13, 1988Date of Patent: August 1, 1989Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Tetsuhiro Kubota, Kenji Akahane, Hideaki Umeyama, Yoshiaki Kiso
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Patent number: 4841067Abstract: Novel amino acid derivatives useful as a therapeutic agent are disclosed. These amino acid derivatives and the pharmaceutically acceptable salts thereof have a human renin inhibitory effect when administered orally and are useful for treatment of hypertension, especially renin-associated hypertension.Type: GrantFiled: August 19, 1988Date of Patent: June 20, 1989Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Tetsuhiro Kubota, Kenji Akahane, Hideaki Umeyama, Yoshiaki Kiso
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Patent number: 4711958Abstract: Amino acid derivatives represented by formula ##STR1## wherein His represents an L-histidyl group, X represents a straight or branched alkoxy group having 1 to 7 carbon atoms, a straight or branched alkylamino group having 1 to 7 carbon atoms, a cycloalkyloxy group having 3 to 7 carbon atoms, a morpholino group, said alkoxy group having one or more halogen atoms as substituents; or a pharmaceutically acceptable salt, are useful in the treatment of hypertension.Type: GrantFiled: April 1, 1987Date of Patent: December 8, 1987Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Tetsuhiro Kubota, Kenji Akahane, Hideaki Umeyama, Yoshiaki Kiso
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Patent number: 4656269Abstract: Novel amino acid derivatives useful as a therapeutic agent are disclosed. These amino acid derivatives and the pharmaceutically acceptable salts thereof have a human renin inhibitory effect when administered orally and are useful for treatment of hypertension, especially renin-associated hypertension.Type: GrantFiled: April 15, 1986Date of Patent: April 7, 1987Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Tetsuhiro Kubota, Kenji Akahane, Hideaki Umeyama, Yoshiaki Kiso
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Patent number: 4632934Abstract: The imidazole derivatives of the formula: ##STR1## wherein R is a hydrogen atom or an alkyl group, A.sub.1 and A.sub.2, which may be the same or different, each is an alkylene or an alkylene group, m is 0 or 1, and Z is ##STR2## wherein R.sub.1 and R.sub.2, which may be the same or different, each is a hydrogen atom or an alkyl group, and the terminal carbon atom bonded to the hetero atom of Z may be bonded to either A.sub.1 or A.sub.2 or COOR group (in the case of m being 0); and the pharmaceutically acceptable salts thereof. These compounds have a strong inhibitory effect on thromboxane synthetase from human or bovine platelet microsomes, and are useful as therapeutically actives for inflammation, hypertension, thrombus, cerebral apoplexy and asthma.Type: GrantFiled: August 21, 1979Date of Patent: December 30, 1986Assignees: Kissei Pharmaceutical Co., Ltd., Ono Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Keniji Akahane, Denichi Momose, Yukio Kamijo, Yukiyoshi Ajisawa
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Patent number: 4623724Abstract: The present invention provides an improved method for producing a nuclear substituted cinnamoylanthranilic acid compound.Illustrative of the process is the reaction of 3,4-dimethoxybenzaldehyde with 2-carboxymalonanilic acid in an inert solvent medium in the presence of piperidine to provide an intermediate salt precipitate, and the salt is treated with an acidic reagent to yield N-(3,4-dimethoxycinnamoyl)anthranilic acid product.Type: GrantFiled: August 14, 1984Date of Patent: November 18, 1986Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Ryoji Yamamoto, Hiromu Harada
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Patent number: 4607046Abstract: 4-(1-Imidazolylmethyl)cinnamic acid hydrochloride monohydrate of the formula: ##STR1## and pharmaceutical compositions containing such compound. The imidazole derivative above has a strong and specific inhibitory effect on thromboxane synthetase from human or bovine platelet microsomes, and is useful as a therapeutical agent for inflammation, hypertension, thrombus, cerebral apoplexy, and asthma.Type: GrantFiled: February 10, 1982Date of Patent: August 19, 1986Assignees: Kissei Pharmaceutical Co., Ltd., Ono Pharmaceutical Co., Ltd.Inventors: Kaname Morita, Shigeo Arikawa, Mitsuo Watanabe, Kinji Iizuka, Kenji Akahane
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Patent number: 4587356Abstract: The present invention provides an improved method for producing a nuclear substituted cinnamoylanthranilic acid compound.Illustrative of the process is the reaction of 3-hydroxy-4-methoxybenzaldehyde with 2-carboxymalonanilic acid in an inert solvent medium in the presence of a molar excess of piperidine to provide a high purity intermediate salt precipitate, and the salt is treated with an acidic reagent to yeild N-(3-hydroxy-4-methoxycinnamoyl)anthranilic acid product.Type: GrantFiled: September 25, 1984Date of Patent: May 6, 1986Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Ryoji Yamamoto, Hiromu Harada
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Patent number: 4486597Abstract: The present invention provides an improved method for producing a nuclear substituted cinnamoylanthranilic acid compound.Illustrative of the process is the reaction of 3,4-dimethoxybenzaldehyde with 2-carboxymalonanilic acid in an inert solvent medium in the presence of piperidine to provide an intermediate salt precipitate, and the salt is treated with an acidic reagent to yield N-(3,4-dimethoxycinnamoyl)anthranilic acid product.Type: GrantFiled: February 7, 1984Date of Patent: December 4, 1984Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamino, Ryoji Yamamoto, Hiromu Harada
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Patent number: 4469865Abstract: 1,3-Disubstituted imidazoles of the general formula (I): ##STR1## wherein A and B may be the same or different, and each is a straight- or branched-chain alkylene or alkenylene group having 1 to 8 carbon atoms, Y is an acyl group having 2 to 10 carbon atoms, an alkoxycarbonyl group having 2 to 7 carbon atoms or an dialkoxymethyl group having 3 to 13 carbon atoms, Z is a cyano group or an alkoxycarbonyl group having 2 to 7 carbon atoms, X is a halogen atom, n is zero or 1. The said compounds are intermediates for producing the imidazole derivatives of the general formula (V) above which possess strong and specific inhibitory effects on thromboxane synthetase and thus are useful as therapeutical agents for treatment of diseases caused by thromboxane A.sub.2.Type: GrantFiled: September 24, 1982Date of Patent: September 4, 1984Assignees: Kissei Pharmaceutical Co., Ltd., Ono Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Ryoji Yamamoto, Hiromu Harada
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Patent number: 4461905Abstract: The imidazole derivatives of the general formula: ##STR1## wherein A and B may be the same or different, and each is a straight- or branched-chain alkylene or alkenylene group having 1 to 8 carbon atoms, D is an acyl group having 2 to 10 carbon atoms, an alkoxycarbonyl group having 2 to 7 carbon atoms or a dialkoxymethyl group having 3 to 13 carbon atoms, Q is a cyano group or an alkoxycarbonyl group having 2 to 7 carbon atoms, X is a halogen atom, Z is ##STR2## (wherein E is a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms, Y is an oxygen atom or a sulfur atom and may be connected with either A or B), n is zero or 1, with the proviso that n is 1 when Y connects with B.Type: GrantFiled: August 30, 1982Date of Patent: July 24, 1984Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Tetsuhide Kamijo, Ryoji Yamamoto, Hiromu Harada
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Patent number: 4320134Abstract: The imidazole compounds of the general formula (I): ##STR1## wherein Y is a carboxyl group, a hydroxymethyl group, an N-di or -mono alkyl substituted or unsubstituted carbamoyl group, a cyano group, or an N-di or -mono alkyl substituted or unsubstituted aminomethyl group, and n is an integer of 3 to 20; and pharmaceutically acceptable salts thereof. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for inflammation, hypertension, thrombus, cerebral apoplexy and asthma.Type: GrantFiled: February 21, 1979Date of Patent: March 16, 1982Assignees: Ono Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Kenji Akahane, Yukio Kamijo, Denichi Momose, Yukiyoshi Ajisawa
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Patent number: 4226878Abstract: Novel imidazole derivatives of the general formula (I): ##STR1## wherein Y is a carboxyl group, an alkoxycarbonyl group, a cyano group, a hydroxymethyl group, an aminomethyl group, a formyl group or a carbamoyl group, and A and B, which may be the same or different, each is a straight- or branched-chain alkylene or alkenylene group, and n and m, which may be the same or different, each is zero or 1, with the proviso that when A is methylene group or n is zero, m is 1; and pharmaceutically acceptable salts thereof. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for the treatment of inflammation, hypertension, thrombus, cerebral apoplexy and asthma.Type: GrantFiled: June 13, 1979Date of Patent: October 7, 1980Assignees: Kissei Pharmaceutical Co., Ltd., Ono Pharmaceutical Co., Ltd.Inventors: Kinji Iizuka, Kenji Akahane, Denichi Momose, Yukio Kamijo, Yukiyoshi Ajisawa
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Patent number: 4070484Abstract: Aromatic carboxylic amides of the general formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, R.sub.3 and R.sub.4 are hydrogen atoms or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxyl group containing 1-4 carbon atoms, and may be the same or different, and n is an integer of 1-3, provided that when two Xs are alkyl or alkoxyl groups, the alkyl groups thereof may be connected together into an alkylene group, and the pharmaceutically acceptable salts thereof, possess a strong antiallergic action and are thus useful for treatment of asthma, hay fever, urticaria and atopic dermatitis.Type: GrantFiled: December 21, 1976Date of Patent: January 24, 1978Assignee: Kissei Pharmaceutical Co., Ltd.Inventors: Kozaburo Harita, Yukiyoshi Ajisawa, Kinji Iizuka, Yukihiko Kinoshita, Tetsuhide Kamijo, Michihiro Kobayashi
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Patent number: 4026896Abstract: New aromatic amidocarboxylic acid derivatives of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a hydrogen atom or an alkyl gp with 1-4 carbon atoms; R.sub.3 and R.sub.Type: GrantFiled: April 16, 1975Date of Patent: May 31, 1977Assignee: Kissei Yakuhin Kogyo Kabushiki Kaisha (Kissei Pharmaceutical Co. Ltd.)Inventors: Kozaburo Harita, Yukiyoshi Ajisawa, Kinji Iizuka, Michio Toda, Yukihiko Kinoshita, Tetsuhide Kamijo, Michihiro Kobayashi
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Patent number: 3940422Abstract: Novel aromatic carboxylic amides of the general formula: ##EQU1## wherein each of R.sub.1 and R.sub.2 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, R.sub.3 and R.sub.4 are hydrogen atoms or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxy group containing 1-4 carbon atoms, and n is an integer of 1-3, with the proviso that when two Xs are alkyl or alkoxy groups, they may be connected together to form a ring, as well as pharmaceutically acceptable salts thereof.These compounds possess a strong antiallergenic action and are thus useful for treatment of asthma, hay fever, anticaria and atopic dermatitis.The above aromatic carboxylic amides can be prepared by reacting a reactive functional derivative of the general formula: ##EQU2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.Type: GrantFiled: January 17, 1974Date of Patent: February 24, 1976Assignee: Kissei Yakuhin Kogyo Kabushiki KaishaInventors: Kozaburo Harita, Yukiyoshi Ajisawa, Kinji Iizuka, Yukihiko Kinoshita, Tetsuhide Kamijo, Michihiro Kobayashi
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Patent number: RE32944Abstract: Novel aromatic carboxylic amides of the general formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is a hydrogen atom or an alkyl group having 1-4 carbon atoms, R.sub.3 and R.sub.4 are hydrogen atoms or together form another chemical bond, each X is a hydroxyl group, a halogen atom, an alkyl group having 1-4 carbon atoms and an alkoxy group containing 1-4 carbon atoms, and n is an integer of 1-3 with the proviso that when .[.Xs.]. .Iadd.X's .Iaddend.are alkyl or alkoxy groups, they may be connected together to form a ring, as well as pharmaceutically acceptable salts thereof.These compounds possess a strong antiallergenic action and are thus useful for treatment of asthma, hay fever, .[.anticaria.]. .Iadd.urticaria .Iaddend.and atopic dermatitis.The above aromatic carboxylic amides can be prepared by reacting a reactive functional derivative of the general formula: ##STR2## where R.sub.1, R.sub.2, R.sub.3, R.sub.Type: GrantFiled: June 1, 1977Date of Patent: June 6, 1989Assignee: Kissei Yakuhin Kogyo KabushikiInventors: Kozaburo Harita, Yukiyoshi Ajisawa, Kinji Iizuka, Yukihiko Kinoshita, Tetsuhide Kamijo, Michihiro Kobayashi