Patents by Inventor Kino D. Andreev

Kino D. Andreev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of preparing 2-(phenylamino)-imidazolines-(2)
    Patent number: 4290971
    Abstract: A process for preparing compounds of the formula: ##STR1## or pharmaceutically acceptable salts thereof, wherein R.sub.1 and R.sub.2 each individually are hydrogen, halogen, or nitro, which comprises the steps of: (a) alkylating a compound of the formula: ##STR2## wherein R.sub.3 is C.sub.1 to C.sub.4 alkyl or phenyl, with a compound of the formula:R.sub.4 --Xwherein R.sub.4 is C.sub.1 to C.sub.6 alkyl or phenyl-alkyl where the alkyl is C.sub.1 to C.sub.4 and X is halogen, in the presence of a base to yield a compound of the formula: ##STR3## and; (b) cyclizing the compound formed during step (a) with ethylenediamine mono-p-toluenesulphonate at a temperature of 100.degree. to 200.degree. C. to yield the desired product. New intermediate compounds are also disclosed. The desired products have antihypertensive properties.
    Type: Grant
    Filed: January 9, 1980
    Date of Patent: September 22, 1981
    Assignee: DSO "Pharmachim"
    Inventors: Atanas G. Georgiev, Kino D. Andreev, Kina V. Konstantinova