Abstract: Certain examples provide systems and methods to assign clinical goals, care plans, and/or care pathways. An example system includes a rule engine including a particularly programmed processor to process ingested clinical data for a patient with respect to a goal, identify a rule applicable to the clinical data and goal for the patient, and apply the rule to the clinical data to generate at least one of an action or a suggestion for the patient based on applying the rule to the clinical data, the at least one of an action or a suggestion applicable to a care plan for the patient to achieve the goal. The example system also includes a rule repository storing rules and associated information for access by the rule engine.