Patents by Inventor Kiran Krishnan

Kiran Krishnan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11786563
    Abstract: The present invention relates to methods of modulating dermal and sub-dermal properties of a subject. The present invention relates to methods comprising administering to a subject a spore-based probiotic composition.
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: October 17, 2023
    Assignee: Novozymes A/S
    Inventors: Kiran Krishnan, Dale M. Kriz, Thomas F. Bayne
  • Publication number: 20230049876
    Abstract: A method of treating metabolic endotoxemia comprising identifying a subject having post-prandial dietary endotoxemia and administering an effective amount of a spore-based probiotic. While any spore-based probiotic may be used, the probiotic supplement may comprise Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, Bacillus licheniformis, and Bacillus clausii. One or more of a level of blood endotoxin, triglyceride, post-prandial insulin, post-prandial ghrelin level, MCP-1, GM-CSF, IL-12p70, IL-13, IL-1beta, IL-4, IL-5, IL-6, IL-7, IL-8, and TNF-? is observed as being lower after spore-based probiotic supplementation when compared to placebo. At least one of post-prandial leptin and IL-10 is observed as being higher after spore-based probiotic supplementation when compared to placebo.
    Type: Application
    Filed: October 18, 2022
    Publication date: February 16, 2023
    Applicant: Novozymes A/S
    Inventors: Kiran Krishnan, Dale Kriz, Thomas Bayne
  • Publication number: 20210401901
    Abstract: The present invention relates to methods of modulating dermal and sub-dermal properties of a subject. The present invention relates to methods comprising administering to a subject a spore-based probiotic composition.
    Type: Application
    Filed: September 7, 2021
    Publication date: December 30, 2021
    Applicant: Novozymes A/S
    Inventors: Kiran Krishnan, Dale M. Kriz, Thomas F. Bayne
  • Patent number: 11129860
    Abstract: The present invention relates to methods of modulating dermal and sub-dermal properties of a subject. The present invention relates to methods comprising administering to a subject a spore-based probiotic composition.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: September 28, 2021
    Assignee: Novozymes, A/S
    Inventors: Kiran Krishnan, Dale M. Kriz, Thomas F. Bayne
  • Publication number: 20210252078
    Abstract: This disclosure relates to a method of evaluating effects of probiotic supplementation on performance and Salmonella load in broilers challenged with Salmonella enterica serovar Enteritidis, said probiotic containing Bacillus subtilis, Bacillus licheniformis, and a cellulose carrier.
    Type: Application
    Filed: September 16, 2020
    Publication date: August 19, 2021
    Applicant: Microbiome Labs, LLC
    Inventors: Kiran Krishnan, Dale M. Kriz, Thomas F. Bayne
  • Publication number: 20210128647
    Abstract: The present invention is directed to methods of administering a probiotic composition including Bacillus subtilis, Bacillus licheniformis, and Pediococcus acidilactici to dogs to decrease endotoxemia and improve the digestive process, and related methods.
    Type: Application
    Filed: September 16, 2020
    Publication date: May 6, 2021
    Applicant: Microbiome Labs, LLC
    Inventors: Kiran Krishnan, Dale M. Kriz, Thomas F. Bayne
  • Publication number: 20210077547
    Abstract: A spore-based probiotic composition is provided that comprises at least one viable probiotic microorganism having a biological or therapeutic effect on microbiome in humans. One exemplary composition contains five different strains of Bacillus spp. Also provided are methods of producing spore-based probiotic compositions. A validated in vitro gut model which is a simulated human intestinal microbial ecosystem reactor was used to assess the long-term effect of the composition on microbial metabolic activity and community composition. The results support use of the composition in protecting against obesity-related disorders, metabolic disorders, inflammation, and cancer, for example. A method for modulating microbial metabolic activity and/or modulating microbial community composition in a human subject is described.
    Type: Application
    Filed: September 14, 2020
    Publication date: March 18, 2021
    Applicant: Microbiome Labs, LLC
    Inventors: Kiran Krishnan, Dale M. Kriz, Thomas F. Bayne
  • Publication number: 20200330528
    Abstract: The present invention relates to methods of modulating dermal and sub-dermal properties of a subject. The present invention relates to methods comprising administering to a subject a spore-based probiotic composition.
    Type: Application
    Filed: January 15, 2020
    Publication date: October 22, 2020
    Applicant: Microbiome Labs, LLC
    Inventors: Kiran Krishnan, Dale M. Kriz, Thomas F. Bayne
  • Publication number: 20180289752
    Abstract: A method of treating metabolic endotoxemia comprising identifying a subject having post-prandial dietary endotoxemia and administering an effective amount of a spore-based probiotic. While any spore-based probiotic may be used, the probiotic supplement may comprise Bacillus indicus (HU36), Bacillus subtilis (HU58), Bacillus coagulans, Bacillus licheniformis, and Bacillus clausii. One or more of a level of blood endotoxin, triglyceride, post-prandial insulin, post-prandial ghrelin level, MCP-1, GM-CSF, IL-12p70, IL-13, IL-1beta, IL-4, IL-5, IL-6, IL-7, IL-8, and TNF-? is observed as being lower after spore-based probiotic supplementation when compared to placebo. At least one of post-prandial leptin and IL-10 is observed as being higher after spore-based probiotic supplementation when compared to placebo.
    Type: Application
    Filed: April 6, 2018
    Publication date: October 11, 2018
    Inventors: Kiran Krishnan, Dale Kriz, Thomas Bayne
  • Publication number: 20150157670
    Abstract: A probiotic composition comprising at least one viable probiotic microorganism having a biological or therapeutic activity in the gastrointestinal tract and a carrier suitable for human consumption is disclosed. The probiotic composition may contain drinking water and electrolytes and the probiotic microorganism may be spores of a probiotic microorganism. Also provided are methods of treating acute or chronic diarrhea and of improving immune function, digestive health, and/or intestinal flora by administering the probiotic composition. In addition, a food additive comprising at least one viable probiotic microorganism having a biological or therapeutic activity in the gastrointestinal tract and a carrier suitable for human consumption is provided.
    Type: Application
    Filed: December 5, 2014
    Publication date: June 11, 2015
    Inventors: Dale M. Kriz, Kiran Krishnan
  • Publication number: 20120149780
    Abstract: The invention relates to Vitamin K, its derivatives and combinations to increase the energy levels in diverse disease states and life style disorders, which are characterized by low energy level due to inadequate VO2max, and pO2 and low availability of ATP molecules. VO2max, peak oxygen uptake, is intimately connected to several diseases and life style disorders such as Metabolically Obese but Normal Weight (MONW), Overweight/Obese, diabetes mellitus, coronary artery disease, hypertension, cerebral vascular insufficiency, immune deficient states, cancer, aging-related disorders, reduced cardiopulmonary reserves and muscular fitness in athletics, high altitude climbing and exercise. The invention discloses that innovative blends of components that, in unique combination, synergistically bestow enhancement of VO2max leading to higher energy level, less fatigability and energy adaptations to stressful stimuli in humans and animals.
    Type: Application
    Filed: March 12, 2010
    Publication date: June 14, 2012
    Inventors: Dilip S Mehta, Anselm De Souza, Ashok B. Vaidya, Rama A. Vaidya, Dale Kriz, Kiran Krishnan
  • Publication number: 20070237828
    Abstract: Pharmaceutical formulations of ziprasidone comprise ziprasidone or a salt thereof, in the form of particles having a mean particle size greater than about 90 ?m and a pharmaceutically acceptable excipient.
    Type: Application
    Filed: June 9, 2005
    Publication date: October 11, 2007
    Applicants: DR. REDDY'S LABORATORIES LIMITED, DR. REDDYS LABORATORIES, INC.
    Inventors: Gouri Vibhuthi, Sudeep Agrawal, Billa Reddy, Kiran Krishnan, Mailatur Mohan
  • Publication number: 20070224260
    Abstract: Mini-tablets comprising a drug substance are formed by compression, using forces sufficiently low to preserve the polymorphic form of the drug. The mini-tablets can be administered directly, filled into capsules, etc.
    Type: Application
    Filed: April 14, 2005
    Publication date: September 27, 2007
    Applicants: DR. REDDY'S LABORATORIES LIMITED, DR. REDDY'S LABORATORIES, INC.
    Inventors: Pavak Mehta, Indu Bhushan, Pasula Chowdary, Kiran Krishnan, Mailatur Mohan