Patents by Inventor Kiran Musunuru

Kiran Musunuru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IN UTERO CRISPR-MEDIATED THERAPEUTIC EDITING OF GENES
    Publication number: 20240075164
    Abstract: A method for in utero genome editing, the method comprising administering to a subject an adenoviral vector, wherein the subject is a fetus, the adenoviral vector comprising CRISPR-mediated base editor and a guide RNA (gRNA), the gRNA targeting a mutation in a therapeutic gene; and introducing a modified codon in the therapeutic gene by base editing the therapeutic gene, wherein the base editing is performed by the adenoviral vector, an adeno-associated viral vector or lipid based nanoparticle.
    Type: Application
    Filed: April 30, 2019
    Publication date: March 7, 2024
    Inventors: Kiran MUSUNURU, William H. PERANTEAU, Edward MORRISEY
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20220333119
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells.
    Type: Application
    Filed: April 25, 2022
    Publication date: October 20, 2022
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • COMPOSITIONS AND METHODS FOR IN UTERO GENE EDITING FOR MONOGENIC LUNG DISEASE
    Publication number: 20220275402
    Abstract: Compositions and methods for in utero gene editing in mammalian lung cells are disclosed.
    Type: Application
    Filed: April 6, 2020
    Publication date: September 1, 2022
    Applicants: THE CHILDREN'S HOSPITAL OF PHILADELPHIA, THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: William H. Peranteau, Edward E. Morrisey, Michael F. Beers, Kiran Musunuru
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20210285015
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders.
    Type: Application
    Filed: May 21, 2021
    Publication date: September 16, 2021
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20210277423
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders.
    Type: Application
    Filed: May 21, 2021
    Publication date: September 9, 2021
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20210274726
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders.
    Type: Application
    Filed: May 21, 2021
    Publication date: September 9, 2021
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20200048659
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders.
    Type: Application
    Filed: February 18, 2019
    Publication date: February 13, 2020
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • Therapeutic uses of genome editing with CRISPR/Cas systems
    Patent number: 10208319
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: February 19, 2019
    Assignees: President and Fellows of Harvard College, The Children's Medical Center Corporation
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20180291383
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells.
    Type: Application
    Filed: November 20, 2017
    Publication date: October 11, 2018
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • Method of making a deletion in a target sequence in isolated primary cells using Cas9 and two guide RNAs
    Patent number: 9822370
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: November 21, 2017
    Assignees: President and Fellows of Harvard College, The Children's Medical Center Corporation
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20150176013
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells.
    Type: Application
    Filed: October 8, 2014
    Publication date: June 25, 2015
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20150152436
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells for treating or preventing genetic blood disorders.
    Type: Application
    Filed: October 8, 2014
    Publication date: June 4, 2015
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/Cas SYSTEMS
    Publication number: 20150071889
    Abstract: Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells.
    Type: Application
    Filed: September 12, 2014
    Publication date: March 12, 2015
    Inventors: Kiran Musunuru, Chad A. Cowan, Derrick J. Rossi
  • METHODS FOR RISK ASSESSMENT, TREATING, AND DIAGNOSING MYOCARDIAL INFARCTION
    Publication number: 20120289593
    Abstract: This document features method related to genetic markers associated with myocardial infarction. For example, methods of using such genetic markers for risk assessment and for diagnosing and treating myocardial infarction are provided.
    Type: Application
    Filed: September 8, 2010
    Publication date: November 15, 2012
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Sekar Kathiresan, Kiran Musunuru
  • Methods And Systems For Providing Interactive Educational Training
    Publication number: 20090061402
    Abstract: The present invention provides computer implemented and interactive educational platforms for training professionals, such as healthcare workers. In particular, the present invention provides learning modules for professionals for implementing an interactive curriculum that is designed to ensure thorough coverage of core and advanced competencies.
    Type: Application
    Filed: August 29, 2007
    Publication date: March 5, 2009
    Inventor: Kiran Musunuru