Abstract: The present invention provides a silk fibroin-based hydrogel and antibiotic composition consists of 5% silk fibroin embedded with 0.4-2% antibiotic, more specifically, tetracycline or doxycycline, and the antibiotic used to prepare the silk fibroin-based hydrogel is super saturated solution, i.e., 100% concentration of antibiotic in de-ionized water. The invention also provides a method to prepare silk fibroin-based hydrogel and antibiotic composition comprising steps of: preparing 5% silk fibroin solution and maintaining at 16-21° C.; adding saturated antibiotic solution in the silk fibroin solution to form silk fibroin-based hydrogel; stabilizing the hydrogel at 16-21° C.; and lyophilising the stabilized hydrogel at 4-6° C. to form a dry hydrogel silk fibroin matrix with drug embedded in it. Further, the invention provides composition of the drug-silk fibroin-based hydrogel formulation and method for using it for wound healing of tooth extraction socket.

Abstract: The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: Techniques are provided for securing reference signals. An example method for transmitting a signal based on a validated pseudo random sequence includes determining secure sequence validation information, generating a pseudo random sequence, validating the pseudo random sequence based on the secure sequence information, and transmitting the signal based at least in part on the validated pseudo random sequence.

Abstract: Provided, in part, are compounds of Formula I: pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of conditions associated with the activity of sodium channels. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Abstract: One or more embodiments provide a method for data storage. For example, the method may include adding a second virtual disk to the VM, the second virtual disk backed by a second virtual disk file. The method may also include creating one or more volumes configured to store container data of the one or more containers, the one or more volumes using storage from the second virtual disk and not the first virtual disk. The method may furthermore include mounting the one or more volumes in the one or more containers. The method may in addition include backing up the second virtual disk file independent from the first virtual disk file to create a copy of the second virtual disk file.

Abstract: One or more information maps are obtained by an agricultural work machine. The one or more information maps map one or more agricultural characteristic values at different geographic locations of a field. An in-situ sensor on the agricultural work machine senses an agricultural characteristic as the agricultural work machine moves through the field. A predictive map generator generates a predictive map that predicts a predictive agricultural characteristic at different locations in the field based on a relationship between the values in the one or more information maps and the agricultural characteristic sensed by the in-situ sensor. The predictive map can be output and used in automated machine control.

Abstract: Methods for controlling a computing device with an inoperable user interface may include broadcasting, by the computing device, a request for another computing device to operate as a substitute user interface for the computing device in response to determining that a user interface of the computing device is inoperable to control an operation of the computing device, receiving from another computing device a message indicating that the other computing device can operate as the substitute user interface for the computing device, and enabling the computing device to respond to user instructions received from the other computing device.

Abstract: One or more information maps are obtained by an agricultural work machine. The one or more information maps map one or more agricultural characteristic values at different geographic locations of a field. An in-situ sensor on the agricultural work machine senses an agricultural characteristic as the agricultural work machine moves through the field. A predictive map generator generates a predictive map that predicts a predictive agricultural characteristic at different locations in the field based on a relationship between the values in the one or more information maps and the agricultural characteristic sensed by the in-situ sensor. The predictive map can be output and used in automated machine control.

Abstract: An agricultural system includes an in-situ sensor that detects a value of a dynamic response characteristic corresponding to a first geographic location, of a plurality of different geographic locations, in a field, one or more processors, and memory storing instructions executable by the one or more processors. The instructions, when executed by the one or more processors, configure the one or more processors to: obtain an information map that includes values of an agricultural characteristic corresponding to the plurality of different geographic locations in the field, identify a predictive value of the dynamic response characteristic corresponding to a second geographic location in the field based on the value of the dynamic response characteristic corresponding to the first geographic location and a value of the agricultural characteristic corresponding to the first geographic location; and control the agricultural work machine based on the predictive value of the dynamic response characteristic.

Abstract: One or more information maps are obtained by an agricultural work machine. The one or more information maps map one or more agricultural characteristic values at different geographic locations of a field. An in-situ sensor on the agricultural work machine senses an agricultural characteristic as the agricultural work machine moves through the field. A predictive map generator generates a predictive map that predicts a predictive agricultural characteristic at different locations in the field based on a relationship between the values in the one or more information maps and the agricultural characteristic sensed by the in-situ sensor. The predictive map can be output and used in automated machine control.

Abstract: An agricultural work machine includes a geographic position sensor that detects a geographic location of the agricultural work machine. An in-situ sensor detects a value of a dynamic response characteristic of the agricultural work machine corresponding to the geographic location. A predictive model generator generates a predictive model that models a relationship between the terrain feature characteristic and the dynamic response characteristic based on a value of the terrain feature characteristic in a prior information map at the geographic location and a value of the dynamic response characteristic sensed by the in-situ sensor at the geographic location. A predictive map generator generates a functional predictive dynamic response map of the field, that maps predictive values of the dynamic response characteristic to the different geographic locations in the field, based on the values of the terrain feature characteristic in the prior information map and based on the predictive model.

Abstract: Solid forms of Pitolisant or its salt are provided. Also provided are solid dispersions of Pitolisant or salt thereof in amorphous form and at least one suitable pharmaceutically acceptable excipient. The process for preparing solid dispersion of Pitolisant or salt thereof is also provided.

Abstract: One or more information maps are obtained by an agricultural work machine. The one or more information maps map one or more agricultural characteristic values at different geographic locations of a field. An in-situ sensor on the agricultural work machine senses an agricultural characteristic as the agricultural work machine moves through the field. A predictive map generator generates a predictive map that predicts a predictive agricultural characteristic at different locations in the field based on a relationship between the values in the one or more information maps and the agricultural characteristic sensed by the in-situ sensor. The predictive map can be output and used in automated machine control.

Abstract: In some implementations, an ultra-wideband (UWB) management server may send a first message to a UWB anchor, wherein: the first message is indicative of a first threshold to use in a UWB positioning session, the first threshold specifying at least one trigger condition for making available one or more reserved time slots in a Contention Access Period (CAP) of the UWB positioning session. The UWB management server may determine a second threshold for identifying a UWB responder having a respective reserved time slot in the CAP. The UWB management server may send a second message to the UWB anchor, wherein the second message causes the UWB anchor to either: (i) move the respective reserved time slot in the CAP for the UWB responder to a respective one or more time slots in a Contention Free Period (CFP), or (ii) terminate the UWB positioning session with the UWB responder.

Abstract: The disclosure is directed to systems, methods, and computer storage media, for, among other things, employing nested model structures to enforce compliance, within a computational system, to at least one policy. One method includes receiving a digital record that encodes content. A plurality of models (e.g., integrated models and/or model droplets) is employed to analyze the records. The plurality of models is configured and arranged within a nested structure of a hierarchy of models. Each of the plurality of models analyzes at least a portion of the record. Based on the nested structure, the hierarchy combines the analysis from each of the plurality of models to determine that the content violates a policy of a system. In response to determining that the content violates the policy, at least one mitigation (or intervention) action are performed. The at least one mitigation action may alter subsequent transmissions of the record.

Abstract: One or more information maps are obtained by an agricultural work machine. The one or more information maps map one or more agricultural characteristic values at different geographic locations of a field. An in-situ sensor on the agricultural work machine senses an agricultural characteristic as the agricultural work machine moves through the field. A predictive map generator generates a predictive map that predicts a predictive agricultural characteristic at different locations in the field based on a relationship between the values in the one or more information maps and the agricultural characteristic sensed by the in-situ sensor. The predictive map can be output and used in automated machine control.

Abstract: In some implementations, an ultra-wideband (UWB) initiator anchor device may receive a first blink message from a mobile device, wherein: the first blink message is sent during a slot of a contention access period (CAP) in a round of a UWB session, and the first blink message comprises a radio frequency (RF) message configured to enable UpLink Time Difference of Arrival (UL-TDoA) measurements by one or more UWB responder anchor devices. The UWB initiator anchor device may transmit a control message from the UWB initiator anchor device indicating a reserved slot in a subsequent contention free period (CFP) of the UWB session, wherein reserving the slot is responsive, at least in part, to receiving the first blink message at the UWB initiator device from the mobile device.

Abstract: Aspects presented herein may enhance the security of UWB ranging, thereby improving the accuracy and reliability of the UWB ranging. In one aspect, a first wireless device embeds first information for generating a secure sequence of a ranging message in a payload section of the ranging message. The first wireless device generates the secure sequence based at least in part on the first information. The first wireless device transmits the ranging message including the secure sequence and the payload section for a second wireless device. In another aspect, a second wireless device receives a ranging message from a first wireless device that includes a first secure sequence and a payload section. The second wireless device generates a second secure sequence based on information embedded in the payload section of the ranging message.

Abstract: In some implementations, a server may send a request to a first wireless device for capability information, wherein the first wireless device is capable of transmitting both cellular and ultra-wideband (UWB) wireless signals. The server may receive a response from the first wireless device, the response comprising the capability information regarding a capability of the first wireless device for performing UWB positioning. The server may determine first UWB assistance data for the first wireless device based at least in part on (i) the capability information and (ii) information regarding one or more positioning signals transmitted in a cellular wireless network, wherein the first UWB assistance data comprises one or more parameters for a first set of one or more UWB positioning sessions between the first wireless device and a second wireless device. The server may send the first UWB assistance data from the server to the first wireless device.

Abstract: Aspects presented herein may improve the efficiency and accuracy of ranging operations, such as ranging operations based on ultra-wideband or sidelink. In one aspect, a first wireless device receives a response message from at least one second wireless device, the response message including a clock accuracy value of the at least one second wireless device, a location confidence value of the at least one second wireless device, or a combination thereof. The first wireless device establishes a ranging session with the at least one second wireless device based on the clock accuracy value of the at least one second wireless device exceeding a clock accuracy threshold, or the location confidence value of the at least one second wireless device exceeding a location confidence threshold, or both.