Patents by Inventor Kirill MAKEDONSKI

Kirill MAKEDONSKI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lipid assemblies and uses thereof and some pH and electrostatic modulating lipids to be used in said assemblies
    Patent number: 10722599
    Abstract: Provided are modified lipid compounds and their use in the formation of lipid assemblies. Also provided are lipid assemblies including (a) an amphoteric lipid including in covalent association with (i) one or more acyl chains; (ii) one or more weak base moiety; (iii) one or more weak acid moiety; the lipid assembly also including (b) one or more additional lipids, at least one of which being a zwitterionic lipid. In some embodiments, the amphoteric lipid is a compound including (a) a tri-functional moiety; (b) two non-phosphate lipid chains associated with two of the functional moieties of said tri-functional moiety; (c) optionally a spacer moiety associated with the third of the functional moieties of said tri-functional moiety; and (d) a polyalkylamine optionally including a short peptide with one to several carboxylic acid residues. Further provided are the uses of the lipid assembly, inter alia, for transfection or cancer treatment.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: July 28, 2020
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Yechezkel Barenholz, Rivka Cohen, Kirill Makedonski, Eylon Yavin, Andreas Ingemann Jensen, Keren Turjeman
  • LIPID ASSEMBLIES AND USES THEREOF AND SOME pH AND ELECTROSTATIC MODULATING LIPIDS TO BE USED IN SAID ASSEMBLIES
    Publication number: 20180043036
    Abstract: Provided are modified lipid compounds and their use in the formation of lipid assemblies. Also provided are lipid assemblies including (a) an amphoteric lipid including in covalent association with (i) one or more acyl chains; (ii) one or more weak base moiety; (iii) one or more weak acid moiety; the lipid assembly also including (b) one or more additional lipids, at least one of which being a zwitterionic lipid. In some embodiments, the amphoteric lipid is a compound including (a) a tri-functional moiety; (b) two non-phosphate lipid chains associated with two of the functional moieties of said tri-functional moiety; (c) optionally a spacer moiety associated with the third of the functional moieties of said tri-functional moiety; and (d) a polyalkylamine optionally including a short peptide with one to several carboxylic acid residues. Further provided are the uses of the lipid assembly, inter alia, for transfection or cancer treatment.
    Type: Application
    Filed: February 4, 2016
    Publication date: February 15, 2018
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., QBI Enterprises Ltd., Rosetta Genomics, Biolab Ltd.
    Inventors: Sharon AVKIN-NACHUM, Tirtsa KLEINMAN, Noga YERUSHALMI, Yechezkel BARENHOLZ, Rivka COHEN, Kirill MAKEDONSKI, Eylon YAVIN, Andreas Ingemann JENSEN, Keren TURJEMAN