Patents by Inventor Kirk B. Lane

Kirk B. Lane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of diagnosing pulmonary hypertension
    Publication number: 20040023280
    Abstract: This invention relates generally to a method of identifying an individual having an increased susceptibility to developing Familial Primary Pulmonary Hypertension (FPPH), as well as to a method for diagnosing an individual suffering from FPPH. The invention also relates to a method of identifying an individual having an increased susceptibility to developing (non-familial) Primary Pulmonary Hypertension (PPH), as well as to a method for diagnosing an individual suffering from PPH.
    Type: Application
    Filed: June 6, 2003
    Publication date: February 5, 2004
    Inventors: James E. Loyd, Kirk B. Lane, John A. Phillips, Richard C. Trembath, Rajiv D. Machado, Jennifer R. Thomson, William C. Nichols, Michael W. Pauciulo, Tatiana Foroud
  • Method of diagnosing pulmonary hypertension
    Patent number: 6642002
    Abstract: This invention relates generally to a method of identifying an individual having an increased susceptibility to developing Familial Primary Pulmonary Hypertension (FPPH), as well as to a method for diagnosing an individual suffering from FPPH. The invention also relates to a method of identifying an individual having an increased susceptibility to developing (non-familial) Primary Pulmonary Hypertension (PPH), as well as to a method for diagnosing an individual suffering from PPH.
    Type: Grant
    Filed: July 17, 2001
    Date of Patent: November 4, 2003
    Assignees: Vanderbilt University, Advanced Research & Technology Institute, Children's Hospital Medical Center, University of Leicester
    Inventors: James E. Loyd, Kirk B. Lane, John A. Phillips, III, Richard C. Trembath, Rajiv D. Machado, Jennifer R. Thomson, William C. Nichols, Michael W. Pauciulo, Tatiana Foroud
  • Nuclear targeted peptide nucleic acid oligomer
    Patent number: 6623966
    Abstract: A composition comprising a nuclear localization sequence and a peptide nucleic acid oligomer (NLS-PNA) is described. Uses of the composition include, but are not limited to: regulation of gene expression, gene therapy, and the production of pharmaceutical nucleic acids and proteins. In addition, the NLS-PNA is useful for scientific and therapeutic transfection and expression of nucleic acids in cells types that previously were resistant to transfection and therapy including quiescent cells, differentiated cells, embryonic stem cells, and eukaryotic cells with intact nuclear membranes. The NLS-PNA can be combined with a membrane transport sequence (MTS) forming a novel compound referred to as an MTS-NLS-PNA wherein the MTS provides transport through the cytoplasmic membrane of a cell.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: September 23, 2003
    Assignee: Vanderbilt University
    Inventor: Kirk B. Lane
  • Method of diagnosing pulmonary hypertension
    Publication number: 20020102576
    Abstract: This invention relates generally to a method of identifying an individual having an increased susceptibility to developing Familial Primary Pulmonary Hypertension (FPPH), as well as to a method for diagnosing an individual suffering from FPPH. The invention also relates to a method of identifying an individual having an increased susceptibility to developing (non-familial) Primary Pulmonary Hypertension (PPH), as well as to a method for diagnosing an individual suffering from PPH.
    Type: Application
    Filed: July 17, 2001
    Publication date: August 1, 2002
    Inventors: James E. Loyd, Kirk B. Lane, John A. Phillips, Richard C. Trembath, Rajiv D. Machado, Jennifer R. Thomson, William C. Nichols, Michael W. Pauciulo, Tatiana Foroud
  • Nuclear targeted peptide nucleic acid oligomer
    Patent number: 6312956
    Abstract: A composition comprising a nuclear localization sequence and a peptide nucleic acid oligomer (NLS-PNA) is described. Uses of the composition include, but are not limited to: regulation of gene expression, gene therapy, and the production of pharmaceutical nucleic acids and proteins. In addition, the NLS-PNA is useful for scientific and therapeutic transfection and expression of nucleic acids in cells types that previously were resistant to transfection and therapy including quiescent cells, differentiated cells, embryonic stem cells, and eukaryotic cells with intact nuclear membranes. The NLS-PNA can be combined with a membrane transport sequence (MTS) forming a novel compound referred to as an MTS-NLS-PNA wherein the MTS provides transport through the cytoplasmic membrane of a cell.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: November 6, 2001
    Assignee: Vanderbilt University
    Inventor: Kirk B. Lane
  • Method of producing pleurodesis
    Patent number: 6103695
    Abstract: The present invention provides a method of producing a pleurodesis in a mammal, comprising introducing a therapeutically effective dose of a pharmaceutical composition comprising TGF.beta. into the pleural cavity.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: August 15, 2000
    Assignee: Vanderbilt University
    Inventors: Kirk B. Lane, Richard Light, Jeffrey M. Davidson