Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a human chromosome 9 open reading frame 72 (C9orf72) gene, as well as methods of inhibiting expression of a C9orf72 gene and methods of treating subjects having a C9orf72-associated disease or disorder, e.g., C9orf72 amyotrophic lateral sclerosis/frontotemporal dementia or Huntington-Like Syndrome Due To C9orf72 Expansions, using such dsRNAi agents and compositions.

Abstract: A hockey puck is disclosed including an internal signal transmitter enabling instantaneous identification of its position as it moves around. The puck includes two molded subcomponents, which encapsulate the signal transmitter. The signal transmitter includes driver electronics and a number of signal transmitters which together generate and emit an electromagnetic signal. The electromagnetic signal is emitted by a plurality of diodes mounted in light pipes enclosed within cavities in the subcomponents that extend to outer surfaces of the hockey puck components. The puck includes two subcomponents that are attached via complimentary sets of concentrically arranged wedges.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a Actin binding LIM protein 3 (ABLIM3) gene, as well as methods of inhibiting expression of an ABLIM3 gene and methods of treating subjects having an ABLIM3-associated disease or disorder, e.g., PTSD or age-related memory loss, using such dsRNAi agents and compositions.

Abstract: The invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs at one or more internal positions on at least one strand, optionally via a linker or carrier.

Abstract: A method of multi-platform social media advertising via digital overlays on real-time video feeds. The method includes providing a host platform, providing third-party social media platforms, providing a host streamer profile managed by the host platform, receiving an advertisement selection with the host platform from the host streamer profile, designating a specific advertisement element from advertisement elements based on the advertisement selection, receiving input through a streamer interface of the host streamer profile to select a subordinate platform from the third-party social media platforms, initializing a real-time video feed associated with the host streamer profile on the host platform, simultaneously broadcasting the real-time video feed to each of the subordinate platform, and outputting, by the host platform, the specific advertisement element as an overlay on the real-time video feed on the real-time video feed.

Abstract: A hockey puck is disclosed including an internal signal transmitter enabling instantaneous identification of its position as it moves around. The puck includes two molded subcomponents, which encapsulate the signal transmitter. The signal transmitter includes driver electronics and a number of signal transmitters which together generate and emit an electromagnetic signal. The electromagnetic signal is emitted by a plurality of diodes mounted in light pipes enclosed within cavities in the subcomponents that extend to outer surfaces of the hockey puck components. The puck includes two subcomponents that are attached via complimentary sets of concentrically arranged wedges.

Abstract: A method of multi-platform social media advertising via digital overlays on real-time video feeds. The method includes providing a host platform, providing third-party social media platforms, providing a host streamer profile managed by the host platform, receiving an advertisement selection with the host platform from the host streamer profile, designating a specific advertisement element from advertisement elements based on the advertisement selection, receiving input through a streamer interface of the host streamer profile to select a subordinate platform from the third-party social media platforms, initializing a real-time video feed associated with the host streamer profile on the host platform, simultaneously broadcasting the real-time video feed to each of the subordinate platform, and outputting, by the host platform, the specific advertisement element as an overlay on the real-time video feed on the real-time video feed.

Abstract: A method of multi-platform social media advertising and revenue sharing via digital overlays on real-time video feeds enables a host streamer profile to select and display one or more advertisement elements on a real-time video feed, which is broadcast on a host social media platform in addition to being broadcast to one or more third-party platforms. The advertisements may be chosen through various means and customized by advertisers according to desired parameters. Each advertisement is associated with a financial compensation amount. After an advertisement or advertisements are displayed on the real-time video feed, the financial compensation amount is distributed among the host streamer profile, the host platform, and each of the at least one social media platform, thus incentivizing each to participate in the social media advertising and revenue sharing system.

Abstract: The disclosure relates to use of double stranded ribonucleic acid (dsRNAi) agents and compositions targeting an amyloid precursor protein (APP) gene, including methods of inhibiting expression of an APP gene and methods of treating subjects having a disease or disorder characterized by enlarged endosomes, e.g., Alzheimer's disease (AD) and Down syndrome (DS), particularly occurrences of such neurodegenerative diseases associated with one or more mutations in presenilin 1 (PSEN1), using such dsRNAi agents and compositions.

Abstract: One aspect of the present invention relates to a double stranded iRNA agent comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic moieties conjugated to one or more internal positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a Filamin A (FLNA) gene, as well as methods of inhibiting expression of an FLNA gene and methods of treating subjects having an FLNA-associated N disease or disorder, e.g., Alzheimer's disease, using such dsRNAi agents and compositions.

Abstract: The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated ocular diseases.

Abstract: One aspect of the present invention relates to a double stranded iRNA agent comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic moieties conjugated to one or more internal positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs.

Abstract: A hockey puck is disclosed including an internal signal transmitter enabling instantaneous identification of its position as it moves around. The puck includes two molded subcomponents, which encapsulate the signal transmitter. The signal transmitter includes driver electronics and a number of signal transmitters which together generate and emit an electromagnetic signal. The electromagnetic signal is emitted by a plurality of diodes mounted in light pipes enclosed within cavities in the subcomponents that extend to outer surfaces of the hockey puck components. The puck includes two subcomponents that are attached via complimentary sets of concentrically arranged wedges.

Abstract: A hockey puck is disclosed including an internal signal transmitter enabling instantaneous identification of its position as it moves around. The puck includes two molded subcomponents, which encapsulate the signal transmitter. The signal transmitter includes driver electronics and a number of signal transmitters which together generate and emit an electromagnetic signal. The electromagnetic signal is emitted by a plurality of diodes mounted in light pipes enclosed within cavities in the subcomponents that extend to outer surfaces of the hockey puck components. The puck includes two subcomponents that are attached via complimentary sets of concentrically arranged wedges.

Abstract: One aspect of the present invention relates to a double stranded iRNA agent comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic moieties conjugated to one or more internal positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic moieties-conjugated double-stranded iRNAs.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a human chromosome 9 open reading frame 72 (C9orf72) gene, as well as methods of inhibiting expression of a C9orf72 gene and methods of treating subjects having a C9orf72-associated disease or disorder, e.g., C9orf72 amyotrophic lateral sclerosis/frontotemporal dementia or Huntington-Like Syndrome Due To C9orf72 Expansions, using such dsRNAi agents and compositions.

Abstract: A method of multi-platform social media advertising and revenue sharing via digital overlays on real-time video feeds enables a host streamer profile to select and display one or more advertisement elements on a real-time video feed, which is broadcast on a host social media platform in addition to being broadcast to one or more third-party platforms. The advertisements may be chosen through various means and customized by advertisers according to desired parameters. Each advertisement is associated with a financial compensation amount. After an advertisement or advertisements are displayed on the real-time video feed, the financial compensation amount is distributed among the host streamer profile, the host platform, and each of the at least one social media platform, thus incentivizing each to participate in the social media advertising and revenue sharing system.