Abstract: A method, computer system, and a computer program product for predicting animal testing measurement levels is provided. The present invention may include referencing a human gene expression profiles data obtained under in vitro chemical treatment. The present invention may include referencing an animal measurements data obtained under in vivo chemical treatment. The present invention may include assigning an animal measurement level to a human gene expression profile by matching at least one identified compound. The present invention may include creating a chemical fingerprint of the identified compound. The present invention may include creating a machine learning feature space as a function of a human gene expression feature and a chemical fingerprint feature of the identified compound for predicting an associated animal measurement level assigned to the at least one human gene expression profile. The present invention may include training a model using the machine learning feature space.