Abstract: Method and system of packaging a pre-filled vial. The method includes simulating, in a processor of a computing system based at least in part on a simulation model that includes a proportional-integral-derivative (PID) controller block, a frictional disengaging of a stopper that is engaged with the pre-filled vial responsive to progressively varying physical conditions within an autoclave chamber, the PID controller block receiving sensor data of the progressively varying physical conditions based on a hybrid sensor network that includes at least one physical sensor and at least one virtual sensor, the pre-filled vial containing a gaseous portion that is separated from air contained within the autoclave chamber by the stopper. Generating, by the processor based on the progressively varying physical conditions, a measure corresponding to a stopper displacement in accordance with the frictional disengaging, and packaging the pre-filled vial based at least in part on the generated stopper placement.

Abstract: Method and system of digitally simulating operational integrity of a pre-filled vial. The method includes simulating, in a processor of a computing system, a frictional disengaging of a stopper from the pre-filled vial responsive to a progressively decreasing ambient pressure, the pre-filled vial containing a gaseous portion that is separated from ambient air by the stopper, and generating, by the processor in accordance with the progressively decreasing ambient pressure, a measure corresponding to an aircraft altitude at which the frictional disengaging is initiated.

Abstract: This invention relates to a process for preparing 2-pyrrolidone (also called 2-pyrrolidinone) and N-methylpyrrolidone (also called N-methylpyrrolidinone) from diammonium succinate in fermentation broth. In the first stage of this invention, renewable carbon resources are utilized to produce diammonium succinate through biological fermentation. In the second stage of this present invention, diammonium succinate is converted into 2-pyrrolidone and N-methylpyrrolidone through a two step reaction. Both the steps of the reaction leading to the production of 2-pyrrolidone and N-methylpyrrolidone are carried out in a solvent phase to prevent the loss of succinimide through hydrolysis.