Patents by Inventor KIRK WILLIAM HERING
KIRK WILLIAM HERING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11944686Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.Type: GrantFiled: April 21, 2023Date of Patent: April 2, 2024Assignee: AKOS BIOSCIENCES, INC.Inventors: Paul M. Hershberger, Yinghui Liu, Kirk William Hering, James Bernard Kramer, Ramanathan S. Lalgudi
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Patent number: 11883499Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.Type: GrantFiled: November 8, 2022Date of Patent: January 30, 2024Assignee: AKOS BIOSCIENCES, INC.Inventors: Paul M. Hershberger, Yinghui Liu, Kirk William Hering, James Bernard Kramer
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Publication number: 20230293700Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.Type: ApplicationFiled: November 8, 2022Publication date: September 21, 2023Inventors: Paul M. Hershberger, Yinghui Liu, Kirk William Hering, James Bernard Kramer, Ramanathan S. Lalgudi
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Publication number: 20230256104Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.Type: ApplicationFiled: April 21, 2023Publication date: August 17, 2023Inventors: Paul M. Hershberger, Yinghui Liu, Kirk William Hering, James Bernard Kramer, Ramanathan S. Lalgudi
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Publication number: 20230256103Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.Type: ApplicationFiled: April 21, 2023Publication date: August 17, 2023Inventors: Paul M. Hershberger, Yinghui Liu, Kirk William Hering, James Bernard Kramer
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Patent number: 11660348Abstract: Disclosed are conjugate molecules formed from an active agent which is linked to a cannabinoid moiety through a specified linker having ester and amide end groups. The active agent can be a COX-2 inhibitor moiety, and the cannabinoid moiety can be a cannabidiol moiety. These conjugate molecules are contemplated to potentially be effective in the treatment of medical conditions.Type: GrantFiled: November 8, 2022Date of Patent: May 30, 2023Assignee: AKOS BIOSCIENCES, INC.Inventors: Paul M. Hershberger, Yinghui Liu, Kirk William Hering, James Bernard Kramer, Ramanathan S. Lalgudi
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Publication number: 20200002261Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: ApplicationFiled: September 11, 2019Publication date: January 2, 2020Applicant: CAYMAN CHEMICAL COMPANY INCORPORATEDInventors: Kirk William Hering, Gilles CHAMBOURNIER, Gregory William ENDRES, Victor FEDIJ, Thomas James KRELL, II, Hussien Mahmoud MAHMOUD
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Patent number: 10450257Abstract: The present invention provides processes for preparing a prostacyclin analog of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: GrantFiled: January 18, 2018Date of Patent: October 22, 2019Assignee: Cayman Chemical Company IncorporatedInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
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Patent number: 10155716Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: GrantFiled: December 22, 2017Date of Patent: December 18, 2018Assignee: Cayman Chemical Company IncorporatedInventors: Gilles Chambournier, Gregory William Endres, Kirk William Hering, Victor Fedij, Hussein Mahmoud Mahmoud
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Publication number: 20180141889Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula I or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: ApplicationFiled: January 18, 2018Publication date: May 24, 2018Applicant: CAYMAN CHEMICAL COMPANY INCORPORATEDInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
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Publication number: 20180118656Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: ApplicationFiled: December 22, 2017Publication date: May 3, 2018Applicant: Cayman Chemical Company IncorporatedInventors: Gilles Chambournier, Gregory William Endres, Kirk William Hering, Victor Fedij, Hussein Mahmoud Mahmoud
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Patent number: 9908834Abstract: The present invention provides processes for preparing a prostacyclin analog of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: GrantFiled: May 1, 2017Date of Patent: March 6, 2018Assignee: Cayman Chemical Company IncorporatedInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
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Patent number: 9890104Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: GrantFiled: November 7, 2014Date of Patent: February 13, 2018Assignee: Cayman Chemical Company IncorporatedInventors: Gilles Chambournier, Gregory William Endres, Kirk William Hering, Victor Fedij, Hussein Mahmoud Mahmoud
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Publication number: 20170297995Abstract: The present invention provides processes for preparing a prostacyclin analogue of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R10 is a linear or branched C1-6 alkyl. The processes of the present invention comprise steps that generate improved yields and fewer byproducts than traditional methods. The processes of the present invention employ reagents (e.g., the oxidizing reagent) that are less toxic that those used in the traditional methods (e.g., oxalyl chloride). Many of the processes of the present invention generate intermediates with improved e.e. and chemical purity; thereby eliminating the need of additional chromatography steps. And, the processes of the present invention are scalable to generate commercial quantities of the final compound.Type: ApplicationFiled: May 1, 2017Publication date: October 19, 2017Applicant: CAYMAM CHEMICAL COMPANY INCORPORATEDInventors: Kirk William Hering, Gilles Chambournier, Gregory William Endres, Victor Fedij, Thomas James Krell, II, Hussein Mahmoud Mahmoud
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Publication number: 20160289158Abstract: The present invention provides amine salts of the prostacyclin analogue of Formula I and processes for generating these amine salts.Type: ApplicationFiled: November 7, 2014Publication date: October 6, 2016Applicant: CAYMAN CHEMICAL COMPANY INCORPORATEDInventors: GILLES CHAMBOURNIER, GREGORY WILLIAM ENDRES, KIRK WILLIAM HERING, VICTOR FEDIJ, HUSSEIN MAHMOUD MAHMOUD