Abstract: A medical tube unclogging system includes a power supply, a reservoir of fluid, a tube for insertion into a lumen of a medical tube having a clog therein, a pump powered by the power supply and connected to the tube for generating a flow of fluid from the reservoir of fluid through the tube, a fitting through which the tube passes having a first opening coupled to the medical tube, a second opening for receiving the tube, and a third opening through which fluid pumped through the tube and into the medical tube, and fragments of the clog can be exhausted. The system may also include a sensor for monitoring a pressure of the fluid flowing through the tube and producing a signal indicative of the pressure, and a controller or processor for receiving the signal from the sensor and adjusting the pump.