Abstract: The invention is drawn to a method for suppressing an immunoresponse in animals by administering an estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different.

Abstract: An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.

Abstract: An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.

Abstract: Dietary fiber, obtained from extracting wheat bran with water, having an average molecular weight of 5.times.10.sup.2 to 1.times.10.sup.5, from 95.3 to 99.0% by weight of a sugar, primarily glucose, and 0.1 to 3.0% by weight protein components. The fiber, when eaten, promotes the digestion and absorption of nutrients, waste excretion and proliferation of Lactobacillus bifidus in the large intestine.

Abstract: Disclosed herein are (1) a fluorescent substance represented by the formula (I), (2) a process for producing the fluorescent substance, and (3) a cell-discriminating agent containing the fluorescent substance as an active ingredient. ##STR1## (wherein n is an integer of 0, 1, 2 or 3 and R represents a residual radical of a fluorescent material.

Abstract: Disclosed herein is an injection containing 3-benzoyloxy-1,3,5(10)-estratriene-17-[4-{p-bis(2-chloroethyl)amino)phenyl }butanoyloxy]acetate, which has been known as an orally administrable anti-tumor substance, as an active ingredient and an ester of iodinated poppy oil fatty acid as a solvent.

Abstract: Disclosed herein is an immunoregulator comprising a derivative of estradiol represented by the formula (I), which immunoregulator has a small influence to the non-specific immunoreactions in general and gives a specific influence to the immunoreactions against an isoantibody.

Abstract: A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C.sub.1 -C.sub.

Abstract: The Chlorambucil derivatives are novel compounds having the formula (I). ##STR1## wherein R represents a hydrogen atom or an acyl group such as ##STR2## and n is 1 or 2. The Chlorambucil derivatives can be produced by binding Chlorambucil to hydroxyl group at 17-position of estradiol or its derivative in the presence of a binding agent selected from the group consisting of compounds having the formulaX(CH.sub.2).sub.n COOHX(CH.sub.2).sub.n COXHOOC(CH.sub.2).sub.n COOH andXOC(CH.sub.2).sub.n COXwherein n is 1 or 2 and X represents a halogen atom.

Abstract: Methylated prostaglandine derivatives are steroids derivatives having at 17 position, methylated prostaglandine group such as(Me).sub.2 --PGE.sub.2 --E(Me).sub.2 --PGE.sub.2 --E--2AC(Me).sub.2 --PGE.sub.2 --E--BA(Me).sub.2 --PGE.sub.2 --E--2AC--BA(Me)--PGF.sub.2 .alpha.--E(Me)--PGF.sub.2 .alpha.--E--3AC(Me)--PGF.sub.2 .alpha.--E--BA or(Me)--PGF.sub.2 .alpha.--E--3AC--BAor 600 mg/kg of the following active ingredient:(Me).sub.2 --PGE.sub.2 '--E(Me).sub.2 --PGE.sub.2 '--E--2AC(Me).sub.2 --PGE.sub.2 '--E--BA(Me).sub.2 --PGE.sub.2 '--E--2AC--BA(Me)--PGE.sub.2 --E(Me)--PGE.sub.2 --E--2AC(Me)--PGE.sub.2 --E--BA or(Me)--PGE.sub.2 --E--2AC--BA.

Abstract: Conjugates of amino sugar-steroid hormone are prepared by binding an amino sugar to steroid hormone at 3- or 17-position by a direct reaction or by binding with a binding agent, and the conjugate is useful in an enzyme immunoassay method.

Abstract: Solid carbon material having extremely high flexural strength can be produced by introducing a sufficient amount of functional group to satisfy the undernoted general equation into a pitch having a H/C atomic ratio of 0.8 at most, thereby obtaining precursory carbon material; shaping said precursory carbon material into a desired article without using any binding material; and carbonizing or further graphitizing said article; wherein the general equation is ##EQU1## where, H/C is the hydrogen-to-carbon atomic ratio of the pitch, R is a numeral ranging from 0.2 to 0.3, and f is the percent by weight of at least one of oxygen, sulfur and halogen contained in the total functional groups introduced into the precursory carbon material on the basis of the weight thereof.

Abstract: The Chlorambucil derivatives are novel compounds having the formula (I). ##STR1## wherein R represents a hydrogen atom or an acyl group such as ##STR2## and n is 1 or 2. The Chlorambucil derivatives can be produced by binding Chlorambucil to hydroxyl group at 17-position of estradiol or its derivative in the presence of a binding agent selected from the group consisting of compounds having the formulaX(CH.sub.2).sub.n COOHX(CH.sub.2).sub.n COXHOOC(CH.sub.2).sub.n COOH andXOC(CH.sub.2).sub.n COXwherein n is 1 or 2 and X represents a halogen atom.

Abstract: A process for producing a steroid hormone-antitumor derivative which selectively affects to tumor or cancer cells comprises reacting X group of a steroid hormone derivative having the formula ##STR1## wherein ST represents a steroid moiety having a cyclophenanthrene hydrocarbon skeleton of gonane, estrane or androstane which is bound to carboxyl group by esterifying OH group on D ring with carboxyl group; and R' represents a C.sub.1 -C.sub.

Abstract: A novel product comprising nitrogen-containing polysaccharides is produced by bringing a culture product of fungi Basidomycetes into reaction with an aqueous ammoniacal solution at a temperature of 100.degree. to 250.degree. C. The product is remarkably effective in controlling various plant viruses.

Abstract: A novel product comprising nitrogen-containing polysaccharides is produced by bringing a culture product of fungi Basidiomycetes into reaction with an aqueous ammoniacal solution at a temperature of 100.degree. to 250.degree. C. The product is remarkably effective in controlling various plant viruses.

Abstract: A process for manufacturing homogeneous and low porosity carbon articles of great mechanical strength from a composition including a sinterable mother material and an additive selected from the group consisting of hydrocarbons, fatty acids, esters and salts of fatty acids, organic compounds having OH functional groups and mixtures thereof, wherein the mother material has an H/C atomic ratio of 0.3 to 0.75, a fixed carbon value of 55 to 96% and does not flow out of a 1 mm diameter nozzle at a temperature of 300.degree. C. under a load of 10 kg/cm.sup.2 ; and the additive has a fixed carbon value of 20% at most, a boiling or decomposition point of at least 150.degree. C. and becomes fluid at a temperature of at least 100.degree. C.

Abstract: Extraction of a fungus of the class Basidiomycetes belonging to the Coriolus genus with an aqueous solvent under pressure and at a temperature of 120.degree. C. to 200.degree. C. gives an anti-transplanted sarcoma 180 tumorigenic substance in a high yield.

Abstract: Prostaglandine derivatives are composed of a prostaglandine and a steriod hormone with or without a binding group.The prostaglandine derivatives have extraordinarily reduced side-effect and superior physiological activity, particularly effect of abortion in comparison with those of prostaglandines.

Abstract: Disclosed is a method for producing trans-4-aminomethyl cyclohexane-1-carboxylic acid by heating and isomerizing cis-4-aminoethyl cyclohexane-1-carboxylic acid hydrochloride or a mixture of cis-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride with trans-4-aminomethyl cyclohexane-1-carboxylic acid hydrochloride in an atmosphere of hydrogen chloride gas and in the absence of a solvent.