Patents by Inventor Kirsty Sarah Hewitson

Kirsty Sarah Hewitson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of identifying a chemical entity which is a hydroxylase modulator
    Patent number: 7778779
    Abstract: A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.
    Type: Grant
    Filed: October 16, 2003
    Date of Patent: August 17, 2010
    Assignee: Isis Innovation Limited
    Inventors: Peter John Ratcliffe, Christopher William Pugh, Christopher Joseph Schofield, Kirsty Sarah Hewitson, Jonathan Mark Elkins
  • Assays for identifying modulators of the hydroxylation of ankyrin repeat proteins by 2-oxoglutarate dependent oxygenase and methods of using the same
    Patent number: 7638295
    Abstract: A method of identifying an agent which modulates 2-oxoglutarate dependent oxygenase activity, the method comprising contacting a 2-oxoglutarate dependent oxygenase and a test agent in the presence of a substrate comprising one or more ankyrin repeat, or fragment thereof, in conditions under which the substrate is hydroxylated in the absence of the test agent; and determining hydroxylation of the substrate.
    Type: Grant
    Filed: March 24, 2005
    Date of Patent: December 29, 2009
    Assignee: Isis Innovation Limited
    Inventors: Christopher Joseph Schofield, Kirsty Sarah Hewitson, Michael Arnold McDonough, Peter John Ratcliffe, Norma Masson, Matthew Edward Cockman
  • Assays
    Publication number: 20080227848
    Abstract: A method of identifying an agent which modulates 2-oxoglutarate dependent oxygenase activity, the method comprising contacting a 2-oxoglutarate dependent oxygenase and a test agent in the presence of a substrate comprising one or more ankyrin repeat, or fragment thereof, in conditions under which the substrate is hydroxylated in the absence of the test agent; and determining hydroxylation of the substrate.
    Type: Application
    Filed: March 24, 2005
    Publication date: September 18, 2008
    Applicant: Isis Innovation Limited
    Inventors: Christopher Joseph Schofield, Kirsty Sarah Hewitson, Michael Arnold McDonough, Peter John Ratcliffe, Norma Masson, Matthew Edward Cockman