Abstract: A door assembly for an automotive vehicle that reduces or eliminates thoracic or rib deflection in a side impact event is disclosed. The door assembly of the disclosed invention includes an inner door structure, an interior trim panel attached to the door structure and a shut face. The inner surface of the shut face includes a collapsible surface having a plurality of alternating raised areas and recessed areas formed thereon. The raised areas and recessed areas extend between one side of the door assembly and the other side of the door assembly. The shut face may be composed of beads, a foamed polymer or a solid polymer. In addition, the engineered surface may also be formed on the inner side of the face of one of the pillars. This configuration may be used in conjunction with a door shut face having an engineered surface or may be used independently.

Abstract: A compound of formula (I), a positional or structural isomer thereof, or a pharmaceutically acceptable base addition salt or acid addition salt thereof, use thereof as a medicament, in particular an anticancer medicament.

Abstract: A door assembly for an automotive vehicle that reduces or eliminates thoracic or rib deflection in a side impact event is disclosed. The door assembly of the disclosed invention includes an inner door structure, an interior trim panel attached to the door structure and a shut face. The inner surface of the shut face includes a collapsible surface having a plurality of alternating raised areas and recessed areas formed thereon. The raised areas and recessed areas extend between one side of the door assembly and the other side of the door assembly. The shut face may be composed of beads, a foamed polymer or a solid polymer. In addition, the engineered surface may also be formed on the inner side of the face of one of the pillars. This configuration may be made in conjunction with a door shut face having an engineered surface or may be used independently.