Patents by Inventor Kisaku Shimura

Kisaku Shimura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing dried microbial cells
    Patent number: 10844347
    Abstract: An object is to provide a method for producing dried microbial cells with a high viable cell survival rate after long-term storage at a high temperature. A method for producing dried microbial cells that achieves the above-mentioned object is characterized in that microbial cells are suspended in a dispersion medium containing a protective agent, an antioxidant, and a chelating agent, followed by drying.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: November 24, 2020
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Masahiko Ito, Kisaku Shimura, Satoru Shirota, Keiko Kasaha, Yasuhiro Moteki, Akihisa Matsui, Satoshi Miida
  • Method for producing dry microbial cell powder
    Patent number: 10465160
    Abstract: An object of the present invention is to develop a means capable of maintaining the enzymatic activity of a microorganism even in a dry state. Provided is a method for producing a dry microbial cell powder maintaining an enzyme titer, characterized by comprising adding a carbohydrate to a liquid of microbial cells having an enzymatic activity and then drying the liquid. Also provided is a dry microbial cell powder obtained by the method.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: November 5, 2019
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Masakazu Ikeda, Hiroshi Ishikawa, Kisaku Shimura, Yuki Fukuda, Masahiko Ito
  • METHOD FOR PRODUCING DRIED MICROBIAL CELLS
    Publication number: 20190062693
    Abstract: An object is to provide a method for producing dried microbial cells with a high viable cell survival rate after long-term storage at a high temperature. A method for producing dried microbial cells that achieves the above-mentioned object is characterized in that microbial cells are suspended in a dispersion medium containing a protective agent, an antioxidant, and a chelating agent, followed by drying.
    Type: Application
    Filed: October 28, 2016
    Publication date: February 28, 2019
    Applicant: Kabushiki Kaisha Yakult Honsha
    Inventors: Masahiko ITO, Kisaku SHIMURA, Satoru SHIROTA, Keiko KASAHA, Yasuhiro MOTEKI, Akihisa MATSUI, Satoshi MIIDA
  • METHOD FOR PRODUCING DRY MICROBIAL CELL POWDER
    Publication number: 20140038269
    Abstract: An object of the present invention is to develop a means capable of maintaining the enzymatic activity of a microorganism even in a dry state. Provided is a method for producing a dry microbial cell powder maintaining an enzyme titer, characterized by comprising adding a carbohydrate to a liquid of microbial cells having an enzymatic activity and then drying the liquid. Also provided is a dry microbial cell powder obtained by the method.
    Type: Application
    Filed: April 12, 2012
    Publication date: February 6, 2014
    Applicant: Kabushiki Kaisha Yakult Honsha
    Inventors: Masakazu Ikeda, Hiroshi Ishikawa, Kisaku Shimura, Yuki Fukuda, Masahiko Ito
  • Thrombolytic peptide, production thereof, and thrombolytic agent
    Patent number: 5475089
    Abstract: A thrombolytic peptide composed of 136 amino acids residues, which has little problems of antigenicity and is efficacious in only small doses as compared with staphylokinase (SAK). This peptide is obtained by cleaving amino acids or peptides which do not affect the activity of SAK by using a trypsin protease. In particular, SAK-11, which is obtained by cleaving a peptide composed of ten amino acid residues at the N-terminal of SAK, is superior to SAK in the fibrinolysis, plasminogen activation, and fibrin specificity.
    Type: Grant
    Filed: June 14, 1993
    Date of Patent: December 12, 1995
    Assignee: Kabushiki Kaisha Yakult Honsha
    Inventors: Osamu Matsuo, Masashi Sakai, Kisaku Shimura, Hiroshi Sansawa, Tsunekazu Watanabe, Tsuneo Matsumoto, Yoshiyuki Shishido, Shusuke Hashimoto, Teruo Yokokura, Masaharu Onoue, Tomoyuki Sako