Patents by Inventor Kishan Rijal
Kishan Rijal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8999640Abstract: Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe material is known to bind to the target nucleic acid. The prepared sensor is exposed to the target nucleic acid. The target nucleic acid binds to the probe material. The mass accumulated on the sensor reflects the amount of target nucleic acid bound to the probe material.Type: GrantFiled: July 31, 2013Date of Patent: April 7, 2015Assignee: Drexel UniversityInventors: Rajakkannu Mutharasan, Kishan Rijal, David R. Maraldo, Gossett Augustus Campbell
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Publication number: 20140045178Abstract: Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe material is known to bind to the target nucleic acid. The prepared sensor is exposed to the target nucleic acid. The target nucleic acid binds to the probe material. The mass accumulated on the sensor reflects the amount of target nucleic acid bound to the probe material.Type: ApplicationFiled: July 31, 2013Publication date: February 13, 2014Applicant: Drexel UniversityInventors: Rajakkannu Mutharasan, Kishan Rijal, David R. Maraldo, Gossett Augustus Campbell
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Patent number: 8512947Abstract: Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe material is known to bind to the target nucleic acid. The prepared sensor is exposed to the target nucleic acid. The target nucleic acid binds to the probe material. The mass accumulated on the sensor reflects the amount of target nucleic acid bound to the probe material.Type: GrantFiled: June 18, 2008Date of Patent: August 20, 2013Assignee: Drexel UniversityInventors: Rajakkannu Mutharasan, Kishan Rijal, David R. Maraldo, Gossett Augustus Campbell
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Patent number: 8511163Abstract: A piezoelectric cantilever sensor includes a piezoelectric layer and a non-piezoelectric layer, a portion of which is attached to the piezoelectric layer. In one embodiment, one end of the non-piezoelectric layer extends beyond the end of piezoelectric layer to provide an overhang. The overhang piezoelectric cantilever sensor enables increased sensitivity allowing application of the device in more viscous environments, such as liquid media, as well as application in liquid media at higher flow rates than conventional piezoelectric cantilevers. In another embodiment, the sensor includes first and second bases and at least one of the piezoelectric layer and the non-piezoelectric layer is affixed to each of the first and second bases to form the piezoelectric cantilever sensor. In this embodiment, the sensor is robust and exhibits excellent sensing characteristics in both gaseous and liquid media, even when subjected to relatively high flow rates.Type: GrantFiled: February 25, 2011Date of Patent: August 20, 2013Assignee: Drexel UniversityInventors: Rajakkannu Mutharasan, David Maraldo, Gossett Augustus Campbell, Kishan Rijal
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Patent number: 8474319Abstract: A piezoelectric cantilever sensor includes a piezoelectric layer and a non-piezoelectric layer, a portion of which is attached to the piezoelectric layer. In one embodiment, one end of the non-piezoelectric layer extends beyond the end of piezoelectric layer to provide an overhang. The overhang piezoelectric cantilever sensor enables increased sensitivity allowing application of the device in more viscous environments, such as liquid media, as well as application in liquid media at higher flow rates than conventional piezoelectric cantilevers. In another embodiment, the sensor includes first and second bases and at least one of the piezoelectric layer and the non-piezoelectric layer is affixed to each of the first and second bases to form the piezoelectric cantilever sensor. In this embodiment, the sensor is robust and exhibits excellent sensing characteristics in both gaseous and liquid media, even when subjected to relatively high flow rates.Type: GrantFiled: February 25, 2011Date of Patent: July 2, 2013Assignee: Drexel UniversityInventors: Rajakkannu Mutharasan, David Maraldo, Gossett Augustus Campbell, Kishan Rijal
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Patent number: 8286486Abstract: The concentration of a material covering a surface is controlled via an equilibrium process. Equilibrium parameters such as a concentration of the provided material, the exposure time of the material to the surface, and the surface area of an attractor applied to the surface are determined utilizing a millimeter sized piezoelectric cantilever sensor. In an example embodiment, the material is provided at a low concentration to the surface until equilibrium is attained. The amount of material accumulated on the surface is determined utilizing the cantilever sensor. The surface area of the attractor and the measured amount of material are utilized to determine the amount of the attractor surface area having the material bound thereto. Knowledge of the equilibrium parameters allows controlled surface coverage of the material on the attractor for any application. The concentration of the material adsorbed on the surface is precisely determinable and repeatable.Type: GrantFiled: May 10, 2007Date of Patent: October 16, 2012Assignee: Drexel UniversityInventors: Rajakkannu Mutharasan, David L. Delesdernier, Kishan Rijal
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Publication number: 20110138915Abstract: A piezoelectric cantilever sensor includes a piezoelectric layer and a non-piezoelectric layer, a portion of which is attached to the piezoelectric layer. In one embodiment, one end of the non-piezoelectric layer extends beyond the end of piezoelectric layer to provide an overhang. The overhang piezoelectric cantilever sensor enables increased sensitivity allowing application of the device in more viscous environments, such as liquid media, as well as application in liquid media at higher flow rates than conventional piezoelectric cantilevers. In another embodiment, the sensor includes first and second bases and at least one of the piezoelectric layer and the non-piezoelectric layer is affixed to each of the first and second bases to form the piezoelectric cantilever sensor. In this embodiment, the sensor is robust and exhibits excellent sensing characteristics in both gaseous and liquid media, even when subjected to relatively high flow rates.Type: ApplicationFiled: February 25, 2011Publication date: June 16, 2011Applicant: DREXEL UNIVERSITYInventors: Rajakkannu Mutharasan, David Maraldo, Gossett Augustus Campbell, Kishan Rijal
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Publication number: 20110138916Abstract: A piezoelectric cantilever sensor includes a piezoelectric layer and a non-piezoelectric layer, a portion of which is attached to the piezoelectric layer. In one embodiment, one end of the non-piezoelectric layer extends beyond the end of piezoelectric layer to provide an overhang. The overhang piezoelectric cantilever sensor enables increased sensitivity allowing application of the device in more viscous environments, such as liquid media, as well as application in liquid media at higher flow rates than conventional piezoelectric cantilevers. In another embodiment, the sensor includes first and second bases and at least one of the piezoelectric layer and the non-piezoelectric layer is affixed to each of the first and second bases to form the piezoelectric cantilever sensor. In this embodiment, the sensor is robust and exhibits excellent sensing characteristics in both gaseous and liquid media, even when subjected to relatively high flow rates.Type: ApplicationFiled: February 25, 2011Publication date: June 16, 2011Applicant: DREXEL UNIVERSITYInventors: Rajakkannu Mutharasan, David Maraldo, Gossett Augustus Campbell, Kishan Rijal
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Patent number: 7942056Abstract: A piezoelectric cantilever sensor includes a piezoelectric layer and a non-piezoelectric layer, a portion of which is attached to the piezoelectric layer. In one embodiment, one end of the non-piezoelectric layer extends beyond the end of piezoelectric layer to provide an overhang. The overhang piezoelectric cantilever sensor enables increased sensitivity allowing application of the device in more viscous environments, such as liquid media, as well as application in liquid media at higher flow rates than conventional piezoelectric cantilevers. In another embodiment, the sensor includes first and second bases and at least one of the piezoelectric layer and the non-piezoelectric layer is affixed to each of the first and second bases to form the piezoelectric cantilever sensor. In this embodiment, the sensor is robust and exhibits excellent sensing characteristics in both gaseous and liquid media, even when subjected to relatively high flow rates.Type: GrantFiled: January 23, 2007Date of Patent: May 17, 2011Assignee: Drexel UniversityInventors: Rajakkannu Mutharasan, David Maraldo, Gossett Augustus Campbell, Kishan Rijal
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Patent number: 7935191Abstract: The techniques described herein are directed to removing material that has attached to or preventing material from attaching to the surface of a piezoelectric cantilever. The material can be a target material, other, non-target, material that may be weakly bound or attached to the cantilever sensor, or the material may be a combination thereof. Accordingly, the cantilever sensor can be reused, in situ, without degraded detection performance of the cantilever sensor. The techniques may also be utilized to remove all material that has attached to a surface of the cantilever sensor which provides means for reusing the cantilever sensor.Type: GrantFiled: August 9, 2007Date of Patent: May 3, 2011Assignee: Drexel UniversityInventors: Rajakkannu Mutharasan, David R. Maraldo, Kishan Rijal, Gossett Augustus Campbell
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Patent number: 7892759Abstract: Detection of miniscule amounts of an analyte is accomplished via multiple bindings of specific materials on a sensor configured to sense mass. The sensor is prepared by immobilizing an antibody to a surface of the sensor, wherein the antibody is known to bind to the analyte. The prepared sensor is exposed to the analyte. The analyte binds to the antibody. The sensor then is exposed to additional antibody, which binds to the analyte. The sensor then can be sequentially exposed to additional antibodies that are known to bind to previously bound antibodies. Each additional binding further increases the effective mass of accumulated material on the sensor. The total effective mass is greater than the mass of the accumulated analyte, thus providing means for detecting extremely minute amounts of analyte. Applications include detection of pathogens and DNA.Type: GrantFiled: February 15, 2008Date of Patent: February 22, 2011Assignees: Drexel University, Leversense, LLCInventors: Rajakkannu Mutharasan, David R. Maraldo, Kishan Rijal, Gossett Augustus Campbell, Paul Karl Horan
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Publication number: 20100018310Abstract: The concentration of a material covering a surface is controlled via an equilibrium process. Equilibrium parameters such as a concentration of the provided material, the exposure time of the material to the surface, and the surface area of an attractor applied to the surface are determined utilizing a millimeter sized piezoelectric cantilever sensor. In an example embodiment, the material is provided at a low concentration to the surface until equilibrium is attained. The amount of material accumulated on the surface is determined utilizing the cantilever sensor. The surface area of the attractor and the measured amount of material are utilized to determine the amount of the attractor surface area having the material bound thereto. Knowledge of the equilibrium parameters allows controlled surface coverage of the material on the attractor for any application. The concentration of the material adsorbed on the surface is precisely determinable and repeatable.Type: ApplicationFiled: May 10, 2007Publication date: January 28, 2010Applicant: Drexel UniversityInventors: Rajakkannu Mutharasan, David L. Delesdernier, Kishan Rijal
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Publication number: 20090203000Abstract: Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass. The sensor is prepared by immobilizing a probe material to a surface of the sensor, wherein the probe material is known to bind to the target nucleic acid. The prepared sensor is exposed to the target nucleic acid. The target nucleic acid binds to the probe material. The mass accumulated on the sensor reflects the amount of target nucleic acid bound to the probe material.Type: ApplicationFiled: June 18, 2008Publication date: August 13, 2009Applicant: DREXEL UNIVERSITYInventors: Rajakkannu Mutharasan, Kishan Rijal, David R. Maraldo, Gossett Augustus Campbell
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Publication number: 20090053709Abstract: Detection of miniscule amounts of an analyte is accomplished via multiple bindings of specific materials on a sensor configured to sense mass. The sensor is prepared by immobilizing an antibody to a surface of the sensor, wherein the antibody is known to bind to the analyte. The prepared sensor is exposed to the analyte. The analyte binds to the antibody. The sensor then is exposed to additional antibody, which binds to the analyte. The sensor then can be sequentially exposed to additional antibodies that are known to bind to previously bound antibodies. Each additional binding further increases the effective mass of accumulated material on the sensor. The total effective mass is greater than the mass of the accumulated analyte, thus providing means for detecting extremely minute amounts of analyte. Applications include detection of pathogens and DNA.Type: ApplicationFiled: February 15, 2008Publication date: February 26, 2009Applicant: Drexel UniversityInventors: Rajakkannu Mutharasan, David R. Maraldo, Kishan Rijal, Gossett Augustus Campbell, Paul Karl Horan
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Publication number: 20080035180Abstract: The techniques described herein are directed to removing material that has attached to or preventing material from attaching to the surface of a piezoelectric cantilever. The material can be a target material, other, non-target, material that may be weakly bound or attached to the cantilever sensor, or the material may be a combination thereof. Accordingly, the cantilever sensor can be reused, in situ, without degraded detection performance of the cantilever sensor. The techniques may also be utilized to remove all material that has attached to a surface of the cantilever sensor which provides means for reusing the cantilever sensor.Type: ApplicationFiled: August 9, 2007Publication date: February 14, 2008Inventors: Rajakkannu Mutharasan, David Maraldo, Kishan Rijal, Gossett Campbell
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Publication number: 20070169553Abstract: A piezoelectric cantilever sensor includes a piezoelectric layer and a non-piezoelectric layer, a portion of which is attached to the piezoelectric layer. In one embodiment, one end of the non-piezoelectric layer extends beyond the end of piezoelectric layer to provide an overhang. The overhang piezoelectric cantilever sensor enables increased sensitivity allowing application of the device in more viscous environments, such as liquid media, as well as application in liquid media at higher flow rates than conventional piezoelectric cantilevers. In another embodiment, the sensor includes first and second bases and at least one of the piezoelectric layer and the non-piezoelectric layer is affixed to each of the first and second bases to form the piezoelectric cantilever sensor. In this embodiment, the sensor is robust and exhibits excellent sensing characteristics in both gaseous and liquid media, even when subjected to relatively high flow rates.Type: ApplicationFiled: January 23, 2007Publication date: July 26, 2007Applicant: Drexel UniversityInventors: Rajakkannu Mutharasan, David Maraldo, Gossett Augustus Campbell, Kishan Rijal