Abstract: In some aspects, the disclosure is directed to methods and systems for artificial intelligence-based evaluation of pharmaceutical drug efficacy. Disclosed are implementations of deep learning that may be used to analyze histological images, study the differentiation of induced pluripotent stem cells, and perform binary classifications (live or dead, drug treated or untreated) on cancer cells or other target cells. Various type of classifiers or deep learning machines may be used in implementations, along with pre-processing in many implementations to further enhance distinctions between affected and unaffected cells.

Abstract: According to an aspect of the present disclosure there is provided a communication device comprising circuitry configured to modulate a four-dimensional input signal by combining the four real-valued signal components of the input signal into a transformed signal and multiplying the transformed signal by carrier signals using two different carrier frequencies to obtain a transmit signal, and transmit the transmit signal.

Abstract: A method for controlling informatics and biological processes is disclosed. The method may include projecting at least one portion of a body of a user with coherent holographic light waves by use of a coherent light source. The method includes generating a plurality of images based on the projection of the at least one portion of the body of the user with the coherent holographic light waves. The method includes analyzing the generated plurality of images to determine at least one of: biological information of the body of the user, or information states of a nervous system associated with the user. The method includes transmitting one or more signals to at least neurons in the body of the user based on the analyzed plurality of images for control of one or more biological processes associated with the user.

Abstract: A method for searching an AD insertion position includes following steps: S1. identifying a human body area in a video image; S2. identifying a blank wall area in the video image; and S3. determining the AD insertion position in the blank wall area in the video image, so that the AD insertion position intersects the human body area. A method for automatically inserting an advertisement AD in a video includes following steps: determining an AD insertion position in the video by searching a product AD insertion position based on deep learning, and inserting the AD on the position. Through the method, an appropriate position for an AD can be automatically searched on a blank wall part in the video. In addition, the inserted AD can be presented in the video in a natural way, and thereby avoiding or reducing the impact of AD insertion on impression of the video.

Abstract: A human-computer interaction method based on in-video advertisements, including steps of: S1. detecting a user's action of activating an in-video advertisement in the process of playing a main video, wherein the in-video advertisement is in an in-video advertisement layer, and the in-video advertisement layer is a logical layer above the main video, and the in-video advertisement layer is logically transparent to the main video except for pixels occupied by the in-video advertisement; and S2. triggering an advertisement action when the user's action of activating the in-video advertisement is detected.

Abstract: A method for searching an AD insertion position includes following steps: S1. identifying a human body area in a video image; S2. identifying a blank wall area in the video image; and S3. determining the AD insertion position in the blank wall area in the video image, so that the AD insertion position intersects the human body area. A method for automatically inserting an advertisement AD in a video includes following steps: determining an AD insertion position in the video by searching a product AD insertion position based on deep learning, and inserting the AD on the position. Through the method, an appropriate position for an AD can be automatically searched on a blank wall part in the video. In addition, the inserted AD can be presented in the video in a natural way, and thereby avoiding or reducing the impact of AD insertion on impression of the video.

Abstract: Methods of reducing incidence of or risk of developing a cerebral folate deficiency (CFD) or a CFD-related disorder comprising administering reduced folate compounds.

Abstract: According to an aspect of the present disclosure there is provided a communication device comprising circuitry configured to modulate a four-dimensional input signal by combining the four real-valued signal components of the input signal into a transformed signal and multiplying the transformed signal by carrier signals using two different carrier frequencies to obtain a transmit signal, and transmit the transmit signal.

Abstract: Disclosed herein are methods for pasting an object to a video. A method may include receiving the video having a plurality of video frames, in which an ending video frame is included; scanning a first video frame of the plurality of video frames, wherein the first video frame has one or more first target objects and one or more second target objects; determining whether a corresponding predetermined video frame information associated with the first video frame is identified in database; if so, segmenting the one or more second target objects; extracting the one or more segmented second target objects from the first video frame; pasting one or more predetermined objects to the one or more first target objects in the video frame, based on the predetermined video frame information associated with the first video frame; and pasting the extracted one or more second target objects to the video frame.

Abstract: An electronic device having a display on one side of the device and one or more image sensors on the opposite side of the device captures image data using the one or more image sensors. The display displays a portion of the captured image data on the display and a first graphical object overlaid on the displayed portion of the captured image data. A user gesture is detected using the one or more image sensors. In accordance with a determination that the detected user gesture meets a set of criteria, a position of the graphical object is updated based on the user gesture or is the first graphical object is replaced with a second graphical object. In accordance with a determination that the detected user gesture does not meet a set of criteria, the display of the first graphical object is maintained.

Abstract: The present invention provides scaffolds that include a polymer and a cyclic peptide ligand. The peptide ligand increases the attachment of endothelial cells and/or progenitor cells to the scaffold. The present invention also provides engineered tissues that include the provided scaffolds. The present invention also provides coatings that include a coating polymer and a cyclic peptide ligand. The present invention also provides methods of improving endothelialization and vascularization of endothelial cells and/or progenitor cells for tissue regeneration in a subject and of repairing bone defects in a subject, by implanting a provided scaffold.

Abstract: The present relates generally to a method for stimulating the activation of an antigen presenting cell. The method includes activating antigen presenting cells by contacting the cells with an effective amount of a GC polymer that has a molecular weight of less than 420 kDa, followed by determining whether the antigen presenting cells are activated by measuring the amount of co-stimulatory marker CD40 expressed by the cells. Also, the present relates to an injectable pharmaceutical composition for stimulating the activation of an antigen presenting cell.

Abstract: Systems and methods for gesture recognition based on depth information from a camera include, at an electronic device having a camera system, capturing a video frame and depth information associated with the video frame, identifying a foreground portion of the video frame based on the depth information, and determining whether the foreground portion matches a predefined gesture in a database. In accordance with a determination that the foreground portion matches a predefined gesture in the database, the device determines whether one or more subsequent video frames matches the one or more predefined gestures to produce a recognized gesture.

Abstract: Provided herein are selectin-binding peptide ligands having both D- and L-amino acids, and peptide conjugates including the provided peptide ligands. The peptide conjugates can include a biopolymer backbone, such as dermatan sulfate, and 33 or fewer peptide ligands conjugated to the biopolymer. Also provided are methods for using the provided peptide conjugates to treat patients suffering from endothelial dysfunction.

Abstract: The present invention provides scaffolds that include a polymer and a cyclic peptide ligand. The peptide ligand increases the attachment of endothelial cells and/or progenitor cells to the scaffold. The present invention also provides engineered tissues that include the provided scaffolds. The present invention also provides coatings that include a coating polymer and a cyclic peptide ligand. The present invention also provides methods of improving endothelialization and vascularization of endothelial cells and/or progenitor cells for tissue regeneration in a subject and of repairing bone defects in a subject, by implanting a provided scaffold.

Abstract: Described herein are methods and systems for receiving a plurality of live video frames; identifying one or more target objects and one or more non-target objects in a first live video frame of the plurality of live video frames, by at least one trained deep neural network; identifying one or more sets of pixels belonging to the one or more target objects; identifying an area on a surface of the one or more target objects, based on the identified one or more sets of pixels belonging to the one or more target objects; overlaying one or more predetermined graphical images onto the area on the surface of the one or more target objects in the plurality of live video frames; and overlaying the one or more non-target objects onto the one or more predetermined graphical images in the plurality of live video frames to form a processed live video.

Abstract: Nucleic acid constructs for heterologous expression of a SARS-CoV-2 antigen on the surface of a yeast cell and related polypeptides, recombinant yeast cells, vaccine compositions, oral dosage formulations, and methods of inducing antigen-specific immune response to SARS-CoV-2.

Abstract: Nucleic acid constructs for heterologous expression of a SARS-CoV-2 antigen on the surface of a yeast cell and related polypeptides, recombinant yeast cells, vaccine compositions, oral dosage formulations, and methods of inducing antigen-specific immune response to SARS-CoV-2.

Abstract: An electronic device having a display, memory, and an image sensor captures image data from the image sensor. The device receives a selection of a background image from a user of the electronic device. The background image 100is not based on image data from the image sensor. The device displays a view on the display or view-fmder. The view is based on the captured image data and the selected background image. The device receives first user input at the electronic device. The displayed view is updated by modifying the background image in accordance with the first user input while maintaining the display of the captured image data. The device stores the view as image data in the memory.

Abstract: At an electronic device coupled to a display, a communication interface, and a first image sensor, first image data is captured from the first image sensor. Second image data is received over the communication interface from a first remote device. The display displays a portion of the second image data with a portion of the first image data. The displayed portion of the second image data obscures some of the first image data.