Patents by Inventor Kithsiri Wijeratne

Kithsiri Wijeratne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 17-BETA-HYDROXYWITHANOLIDES AND USE THEREOF IN TREATING CANCER
    Publication number: 20210047363
    Abstract: Disclosed are compounds suitable for enhancing cancer treatment, for example, a compound of formula (I): (I) wherein R1 is as defined herein. Also disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, a method of inducing apoptosis in cancer cells in a mammal, and a method of treating prostate cancer in mammal in need thereof comprising administration of a compound described herein.
    Type: Application
    Filed: March 6, 2019
    Publication date: February 18, 2021
    Applicants: The United States of America,as represented by the Secretary,Department of Health and Human Services, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Thomas J. Sayers, Poonam Tewary, Leslie Gunatilaka, Alan D. Brooks, Kithsiri Wijeratne, Yaming Xu
  • Method of sensitizing cancer cells to the cytotoxic effects of apoptosis inducing ligands in cancer treatment
    Patent number: 10849912
    Abstract: Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effective amount of a compound of the formula: (I), wherein R1-R14 are as described herein. Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with the compound described herein and also contacting the cancer cells with an apoptosis inducing ligand, whereby apoptosis is induced in the cancer cells.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: December 1, 2020
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Thomas Joseph Sayers, Alan David Brooks, Curtis J. Henrich, Poonam Tewary, James Brislin McMahon, Leslie Gunatilaka, Ya-Ming Xu, Kithsiri Wijeratne
  • METHOD OF SENSITIZING CANCER CELLS TO THE CYTOTOXIC EFFECTS OF APOPTOSIS INDUCING LIGANDS IN CANCER TREATMENT
    Publication number: 20190046543
    Abstract: Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effective amount of a compound of the formula: (I), wherein R1-R14 are as described herein. Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with the compound described herein and also contacting the cancer cells with an apoptosis inducing ligand, whereby apoptosis is induced in the cancer cells.
    Type: Application
    Filed: February 9, 2017
    Publication date: February 14, 2019
    Applicants: The United States of America, as represented by the Secretary, Department of Healthe and Human, Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Thomas Joseph Sayers, Alan David Brooks, Curtis J. Henrich, Poonam Tewary, James Brislin McMahon, Leslie Gunatilaka, Ya-Ming Xu, Kithsiri Wijeratne
  • WITHAFERIN A ANALOGS AND USES THEREOF
    Publication number: 20170066797
    Abstract: The present invention provides a novel class of withanolides that have been isolated from W. somnifera under aeroponic conditions or produced semi-synthetically from withanolide natural products. The invention also provides pharmaceutical compositions thereof and methods for using the same in proliferative diseases, neurodegenerative diseases, autoimmune, and inflammatory diseases.
    Type: Application
    Filed: June 7, 2016
    Publication date: March 9, 2017
    Applicants: Whitehead Institute for Biomedical Research, Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Leslie Gunatilaka, Ekanayake Mudiyanselage Kithsiri Wijeratne, Ya-Ming Xu, Luke Whitesell, Susan L. Lindquist
  • WITHAFERIN A ANALOGS AND USES THEREOF
    Publication number: 20110230551
    Abstract: The present invention provides a novel class of withanolides that have been isolated from W. somnifera under aeroponic conditions or produced semi-synthetically from withanolide natural products. The invention also provides pharmaceutical compositions thereof and methods for using the same in proliferative diseases, neurodegenerative diseases, autoimmune, and inflammatory diseases.
    Type: Application
    Filed: September 15, 2009
    Publication date: September 22, 2011
    Inventors: Leslie Gunatilaka, Ekanayake Mudiyanselage Kithsiri Wijeratne, Ya-Ming Xu, Luke Whitesell, Susan L. Lindquist