Abstract: The present invention provides methods for preventing, treating, managing and/or ameliorating a condition associated with inflammation (e.g., an inflammatory disorder) or a symptom thereof, the methods comprising administering to a subject in need thereof an effective amount of a theaflavin composition and an effective amount of one or more therapies other than such a theaflavin composition. In particular, the present invention provides methods for preventing, treating, managing and/or ameliorating a condition associated with inflammation (e.g., an inflammatory disorder) or a symptom thereof, the methods comprising administering to a subject in need thereof an effective amount of a theaflavin composition, an effective amount of a glucosamine composition, and optionally one or more other therapies.

Abstract: The present invention provides methods for management fat accumulation in an adipocyte using compositions comprising a polymethoxylated flavone fraction of at least one of 5,6,7,3?,4?-pentamethoxyflavone (sinensetin); 5,6,7,8,3?,4?-hexamethoxyflavone (nobiletin); 5,6,7,8,4?-pentamethoxyflavone (tangeretin); 5-hydroxy-6,7,8,3?,4?-pentamethoxyflavone (auranetin); 5-hydroxy-7,8,3?,4?-tetramethoxyflavone; 5,7-dihydroxy-6,8,3?,4?-tetramethoxyflavone; 5,7,8,3?,4?-pentamethoxyflavone; 5,7,8,4?-tetramethoxyflavone; 3,5,6,7,8,3?,4?-heptamethoxyflavone; 5-hydroxy-3,6,7,8,3?,4?-hexamethoxyflavone; 5-hydroxy-6,7,8,4?-tetramethoxyflavone; 5,6,7,4?-tetramethoxyflavone; 7-hydroxy-3,5,6,8,3?,4?-hexamethoxyflavone; or 7-hydroxy-3,5,6,3?,4?-pentamethoxyflavone. In certain embodiments, methods for preventing rebound weight gain in a subject who has experienced weight loss are provided.